A5103218204- Seismic Waves and Analysis
- Seismic Imaging and Inversion Techniques
- earthquake and tectonic studies
- High-pressure geophysics and materials
- CRISPR and Genetic Engineering
- Geological and Geochemical Analysis
- Endoplasmic Reticulum Stress and Disease
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
- Wireless Sensor Networks and IoT
- Metabolomics and Mass Spectrometry Studies
- interferon and immune responses
- Influenza Virus Research Studies
- Pancreatic function and diabetes
- Ion-surface interactions and analysis
- 3D Printing in Biomedical Research
- Earthquake Detection and Analysis
- Analytical chemistry methods development
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Mass Spectrometry Techniques and Applications
- Ferroptosis and cancer prognosis
- Cancer Research and Treatments
- Hydrocarbon exploration and reservoir analysis
- RNA and protein synthesis mechanisms
Harbin Veterinary Research Institute
2018-2025
Chinese Academy of Agricultural Sciences
2018-2025
Chifeng University
2025
Chinese Academy of Geological Sciences
2022-2025
Ministry of Natural Resources
2022-2024
Stanford University
2017-2023
Ministry of Water Resources of the People's Republic of China
2022-2023
Czech Academy of Sciences, Institute of Geology
2022
Sangamo BioSciences (United States)
2022
Foshan University
2022
Rationale: Recent advances have improved our ability to generate cardiomyocytes from human induced pluripotent stem cells (hiPSCs) and embryonic (hESCs). However, understanding of the transcriptional regulatory networks underlying early stages (ie, mesoderm cardiac mesoderm) cardiomyocyte differentiation remains limited. Objective: To characterize transcriptome chromatin accessibility during hiPSCs hESCs. Methods Results: We profiled temporal changes in at genome-wide levels derived 2 hiPSC...
Abstract The global dissemination of H5 avian influenza viruses represents a significant threat to both human and animal health. In this study, we conducted genome‐wide siRNA library screening against the highly pathogenic H5N1 virus, leading us identification 457 cellular cofactors (441 proviral factors 16 antiviral factors) involved in virus replication cycle. Gene Ontology term enrichment analysis revealed that candidate gene data sets were enriched categories associated with mRNA...
Transcription and replication of the influenza A virus (IAV) genome occur in nucleus infected cells are carried out by viral ribonucleoprotein complex (vRNP). As a major component vRNP complex, nucleoprotein (NP) mediates nuclear import via its localization signals (NLSs). Clearly, an effective way for host to antagonize IAV infection would be targeting import. Here, we identified phospholipid scramblase 1 (PLSCR1) as binding partner NP using yeast two-hybrid (Y2H) screen. The interaction...
To complete its replication cycle, IAV hijacks the host endocytosis machinery to invade cells. However, underlying mechanisms of how is internalized into cells remain poorly understood, emphasizing need elucidate role factors in entry In this study, we identified FFAR2 as an important factor for efficient both low-pathogenic and highly pathogenic IAV. We revealed that facilitates internalization target during early stage infection. Upon further characterization FFAR2-associated proteins...
Utilizing short-period dense seismic arrays, ambient noise tomography has proven effective in delineating continuous geological structures, a task critical for characterizing shale gas reservoir configurations. This study deployed 153 stations across the Xiahuayuan District Zhangjiakou, region with prospective deposits, to perform an survey. Through meticulous process involving cross-correlation analysis, dispersion curve extraction, and subsequent inversion, three-dimensional velocity...
Objective: The objective of this study is to conduct network toxicology analysis based on smoking habits and develop a simpler more effective product ingestion control system. Background: Smoking behavior can affect the pathogenesis prognosis neuroimmune gastrointestinal diseases. Aims: purpose developing tools assist clinical practice avoid harm cigarettes human body. Methods: Molecular dynamics method was used elucidate biophysical mechanism TP53 gene mutation caused by harmful...
The ongoing collision between Indian and Asian continents has created the Tibetan plateau. northeastern plateau (NE Tibet) long been a key region for studying its expansion mechanism. However, detailed lithospheric structures across tectonic boundaries bordering blocks have not fully imaged, which obscured understanding of how interacts with other blocks, like Ordos block. Therefore, about 227 stations less than 1-km intervals were deployed from 1st October 2024 one month, crossing NE Tibet,...
ABSTRACT SLC35B4, a nucleotide sugar transporter that mediates the transport of UDP-GlcNAc and UDP-xylose, was found to be required for replication influenza A virus (IAV) H5N1 subtype in our genome-wide siRNA library screen. We defective IAV SLC35B4-deficient A549 cells independent strain specificity, virulence Slc35b4 knockdown mice also decreased. By examining individual stages cycle, we discovered amount internalized significantly reduced SLC35B4-knockout cells. Mechanistically, SLC35B4...
Abstract Background: The pandemic of novel coronavirus disease 2019 (COVID-19) has become a serious public health crisis worldwide. symptoms COVID-19 vary from mild to severe among different age groups, but the physiological changes related are barely understood. Methods: In present study, high-resolution mass spectrometry (HRMS)-based lipidomic strategy was used characterize endogenous plasma lipids for cured patients with ages and symptoms. These were further divided into two groups: those...
The microenvironment plays a significant role in human cancer progression. However, the of tumor epigenetic control genes critical to progression remains unclear. As transient E-cadherin expression is central many stages neoplasia and sensitive regulation by microenvironment, we have studied if microenvironmental linked its promoter, contributing unstable reversible seen during We used 3D, bioengineered tissue constructs that mimic complexity their vivo counterparts, show can direct...
Biallelic mutations in the gene that encodes enzyme N-glycanase 1 (NGLY1) cause a rare disease with multi-symptomatic features including developmental delay, intellectual disability, neuropathy, and seizures. NGLY1's activity human neural cells is currently not well understood. To understand how NGLY1 loss leads to specific phenotypes of deficiency, we employed direct conversion patient-derived induced pluripotent stem (iPSCs) functional cortical neurons. Transcriptomic, proteomic, studies...
Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid malignancies. The exact mechanisms carcinogenesis due to haploinsufficiency remain unclear, but one possibility is that at-risk cells are subject acute periods decreased availability function ("BRCA2-crisis"), which may contribute disease. Here, we establish an in vitro model BRCA2-crisis demonstrates chromatin remodeling activation NF-κB survival pathway response...
N-Glycanase 1 (NGLY1) deficiency is a rare and complex genetic disorder. Although recent studies have shed light on the molecular underpinnings of NGLY1 deficiency, systematic characterization gene protein expression changes in patient-derived cells has been lacking. Here, we performed RNA-sequencing mass spectrometry to determine transcriptomes proteomes 66 cell lines representing four different types derived from 14 deficient patients 17 controls. levels were up 9.5-fold downregulated...
The middle segment of the Xiaojiang fault zone consists strike-slip faults with frequent strong and medium–strong earthquakes under joint influence NE-trending deep structural characteristics. distribution characteristics subfaults each branch need to be revealed. Two short-period dense array survey lines are deployed in area. Shear wave velocity structures obtained using ambient noise tomography. results reveal that dip nearly eastward, north‒south direction. Strong lateral variation infer...
The eastern segment of the Qilian orogenic belt, comprising Linxia block and Longzhong block, is at Qinghai–Tibet Plateau’s northeastern margin. area has experienced multiple tectonic events, including closure Ocean, convergence North China terrane, collision Indian Eurasian plates, forming a complex framework. To investigate area’s geological evolution suture’s current location between blocks, we used 3-year data recorded by 33 portable ChinArray II broadband stations (2013–2016). Using...
Objective Oropharyngeal squamous cell carcinoma (OPSCC) is a malignant tumor that occurs at the tongue base, soft palate, palatine tonsil, and pharyngeal wall. Few studies of OPSCC have been performed in elderly patients. Methods Patients with human papilloma virus (HPV)-related were extracted from Head Neck HPV Status Database Surveillance, Epidemiology, End Results (SEER) database between 2010 2016. We identified 355 patients HPV-positive status, we retrospectively evaluated (≥65 years)...
Rationale The Maillard reaction plays an important role in food, physiology and traditional Chinese medicine, its primary products are formed through Amadori rearrangement by reducing sugars amino acids. analysis of the characteristic fragmentation glycosidic bond configuration compounds will promote their fast discovery identification mass spectrometry. Methods Four that reduce disaccharides proline/tryptophan were used to investigate mechanisms via tandem spectrometry (MS/MS) with...