A5010897644- Tracheal and airway disorders
- Influenza Virus Research Studies
- Trauma Management and Diagnosis
- Animal Virus Infections Studies
- Cleft Lip and Palate Research
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- interferon and immune responses
- Tissue Engineering and Regenerative Medicine
- Vascular Anomalies and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Neonatal Respiratory Health Research
- Receptor Mechanisms and Signaling
- Chemokine receptors and signaling
- Antifungal resistance and susceptibility
- RNA Research and Splicing
- Inhalation and Respiratory Drug Delivery
- Viral Infections and Immunology Research
- Cancer Mechanisms and Therapy
- Fungal Infections and Studies
- Cell Adhesion Molecules Research
- Genetic Syndromes and Imprinting
- Peptidase Inhibition and Analysis
- Bacteriophages and microbial interactions
South China Normal University
2024
Harbin Veterinary Research Institute
2019-2023
Chinese Academy of Agricultural Sciences
2019-2023
Gansu Agricultural University
2022
China Medical University
2003-2017
To complete its replication cycle, IAV hijacks the host endocytosis machinery to invade cells. However, underlying mechanisms of how is internalized into cells remain poorly understood, emphasizing need elucidate role factors in entry In this study, we identified FFAR2 as an important factor for efficient both low-pathogenic and highly pathogenic IAV. We revealed that facilitates internalization target during early stage infection. Upon further characterization FFAR2-associated proteins...
Abstract As a major component of the viral ribonucleoprotein (vRNP) complex in influenza A virus (IAV), nucleoprotein (NP) interacts with isoforms importin α family members, leading to import itself and vRNP into nucleus, process pivotal replication cycle IAV. In this study, we found that BinCARD1, an isoform Bcl10-interacting protein CARD (BinCARD), was leveraged by IAV for efficient replication. BinCARD1 promoted nuclear newly synthesized NP thus enhanced activity. Moreover, interacted...
The Goose/Guangdong-lineage H5 viruses have evolved into diverse clades and subclades based on their hemagglutinin (HA) gene during circulation in wild birds poultry. Since late 2013, the clade 2.3.4.4 become widespread poultry bird populations around world. Different subtypes of viruses, including H5N1, H5N2, H5N6, H5N8, caused vast disease outbreaks Asia, Europe, North America. In this study, we developed a new H5N1 inactivated vaccine by using seed virus (designated as Re-8) that contains...
The transcription and replication of the genome influenza A virus (IAV) take place in nucleus infected cells, which is catalyzed by viral ribonucleoprotein (vRNP) complex. nuclear import vRNP complex its component proteins essential for efficient IAV therefore prone to be targeted host restriction factors. Herein, we found that cellular protein keratin 6A (KRT6A) a negative regulator because siRNA-mediated knockdown KRT6A expression increased growth titers IAV, whereas exogenous...
Influenza A viruses (IAVs) continue to cause tremendous economic losses the global animal industry and respiratory diseases deaths among humans. The nuclear import of vRNP complex, composed polymerase basic protein 1 (PB1), 2 (PB2), acidic (PA), nucleoprotein (NP), viral RNA, is essential for efficient replication IAV. Host factors involved in this process can be targeted development countermeasures against IAV infection. Here, we found that Ankyrin Repeat BTB Domain Containing (ABTB1)...
Tracheobronchial aspergillosis is a form of invasive limited to the airways. Its presence usually indicates an immunocompromised status or local dysfunction airway immunity. We herein report case lung carcinosarcoma masked by tracheobronchial and discuss clinical manifestations, diagnostic procedures treatment such cases. may also mask endobronchial carcinoma, leading difficulties in determining diagnosis selecting subsequent treatment. Bronchoscopy crucial for obtaining definitive...
Tracheal reconstruction has been an important issue in clinic, but it is limited for the ability of epithelial regeneration. Several reports have shown that stromal cell-derived factor-1 (SDF-1) and chemokine receptor CXCR4 play role cell proliferation migration multiple types. But there no report SDF-1 tracheal cells. In this paper, rat cells covered with cilium were isolated cultured using two enzyme digestions, lentivirus was constructed infected to successfully. The results showed...
Aplysia ras homolog I (ARHI) is a Ras-related maternally imprinted tumor suppressor gene. Loss of ARHI expression contributes to the malignant progression various tumors. However, reports on clinical implications and functional role in esophageal squamous cell carcinoma (ESCC) are limited. This study examined ESCC.In total, 81 patients diagnosed with ESCC based histopathological evaluations who were subjected surgical resection included study. was analyzed by immunohistochemistry western...
Objective To investigate the role of BMSCg on enhancing implant survival and bacheal epithelium regeneration. Methods After transplanted with cryopreserved 2 weeks 6 allocraft, PHK-26 labeled 3-5 passage BMSCs were injected into recipient rats via tail vein. Rats in control groups same amount PBS.We observed histology trachea including growth regeneration, PKH-26 fluorescence levels at para-anastomotic to evaluate BMSC transplantation Results from injection group survived a long period....
Influenza A virus (IAV) is an important zoonotic pathogen, posing a severe burden for the health of both animals and humans. Many host factors are involved in life cycle IAV to regulate its replication. Herein, we identified sorting nexin-16 (SNX16) as new factor that negatively modulates replication IAV. When transiently overexpressed cells, SNX16 appears be expressed two obvious bands. Mutagenesis analysis indicated amino acid residue R144 was responsible two-band expression phenotype. We...