A5086103528- Pharmacological Effects of Natural Compounds
- Cancer therapeutics and mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Natural product bioactivities and synthesis
- Ion Channels and Receptors
- Bioactive Compounds and Antitumor Agents
- Advancements in Transdermal Drug Delivery
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Ginseng Biological Effects and Applications
- Biochemical Analysis and Sensing Techniques
- Antifungal resistance and susceptibility
- Sirtuins and Resveratrol in Medicine
- Adrenal Hormones and Disorders
- Dermatology and Skin Diseases
- Biosimilars and Bioanalytical Methods
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Biomedical Text Mining and Ontologies
- Chronic Myeloid Leukemia Treatments
- Atherosclerosis and Cardiovascular Diseases
- Chronic Kidney Disease and Diabetes
- Semantic Web and Ontologies
- Genetic and Kidney Cyst Diseases
- Phytochemistry and biological activity of medicinal plants
- Gastrointestinal motility and disorders
Southern Medical University
2015-2024
Nanfang Hospital
2015-2024
Harbin Medical University
2021
Second Affiliated Hospital of Harbin Medical University
2021
Abstract Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis chronic kidney diseases. As Klotho is large transmembrane it challenging to harness as therapeutic remedy. Here we report discovery Klotho-derived peptide 1 (KP1) protecting kidneys by targeting TGF-β signaling. By screening series peptides derived from human identified KP1 that repressed fibroblast activation binding receptor 2 (TβR2) and disrupting TGF-β/TβR2 engagement. such, blocked TGF-β-induced...
Paclitaxel (PTX, taxol), a classical antitumor drug against wide range of tumors, shows poor oral bioavailability. In order to improve the bioavailability PTX, glycyrrhizic acid (GA) was used as carrier in this study. This first report on preparation, characterization and pharmacokinetic study rats PTX-loaded GA micelles The micelles, prepared with ultrasonic dispersion method, displayed small particle sizes spherical shapes. Differential scanning calorimeter (DSC) thermograms indicated that...
The expression and function of P-glycoprotein (P-gp) is associated with the phenotype multi-drug resistance (MDR), leading chemotherapy failure patients suffered cancer. Grape seed procyanidin(GSP) a natural polyphenol supplement anti-inflammatory effect. Present study assessed new use GSP on MDR reversal activity its possible molecular mechanisms in MDR1-overpressing paclitaxel resistant ovarian cancer cells. Our results showed significantly enhanced cytotoxicity adriamycin A2780/T cells...
Context: As the first-line agent for genital warts, podophyllotoxin (POD) could induce extensively skin burning, itching, and erythema. Meanwhile, as a common anti-inflammatory agent, glycyrrhizic acid (GA), also has amphipathic solubilizing properties, indicating that it might be promising drug carrier.Objective: The objective of this study is to formulate characterize POD-loaded GA micelles preparation evaluate its release characteristics properties.Materials methods: novel was prepared by...
// Sheng-qi Wang 1 , Shi-ting Liu Bo-xin Zhao Fu-heng Yang Ya-tian Qian-ying Liang Ya-bin Sun 2 Yuan Zhi-hua Song Yun Cai Guo-feng Li Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China GCP Center, Correspondence to: Guo-Feng Li, e-mail: liguofeng_2010@126.com Keywords: tyrosine kinase inhibitor, afatinib, ovarian cancer, multidrug resistance, ABCB1 Received: March 12, 2015 Accepted: July 10, Published: 20, ABSTRACT ABCB1-mediated resistance (MDR)...
PurposeThis study aimed to develop a population pharmacokinetic (PPK) model for meropenem optimize dosing regimens critically ill patients with pulmonary infection.Patients and methodsThis prospective PPK of was conducted on pooled dataset 236 blood samples obtained from 48 infection in the intensive care unit. Meropenem plasma concentrations were measured by validated high-performance liquid chromatography-tandem mass spectrometry method, data analyzed using NONMEM. The effect covariates...
Developing a new drug delivery system is one of the useful approaches to overcome limited use berberine (BBR) enhance its absorption and bioavailability. We prepared novel berberine–glycyrrhizic acid (BBR–GL) complex formulation increase plasma concentration bioavailability BBR by improving solubility lowering barrier. The with GL in ratio 1:1 was developed through self-assembly process evaluated vitro . Compared BBR/GL physical mixture, BBR–GL showed different characteristics SEM, DSC,...
Small cell lung cancer (SCLC) remains one of the most aggressive tumors with a poor prognosis. The clinical outcome SCLC patients has reached its plateau existing standard treatment and thus new therapies are urgently required. Accumulating evidences have indicated that doxycycline, commonly used antibiotic, antitumor activity against several malignancies. However, whether doxycycline in underlying mechanisms remain unclear. Our investigation demonstrated could significantly inhibit...
Background and Purpose: Novobiocin (NOVO), an ABC transporter inhibitor, decreases intestinal wall permeability of capsaicin (CAP), substrate. However, the mechanism this effect is not consistent with action NOVO as inhibitor. We previously found that CAP can also be transported via TRPV1, which was site-specific in across intestine. explored regulation by TRPV1 present study. Methods: Rats transfected IEC-6 cells were used models to assess expression TRPV1. Ussing chamber intracellular...
Background.Abnormal CD4 + T cells appear in the peripheral blood of patients with acute coronary syndrome (ACS).Studies have confirmed that are resistant to apoptosis, but specific mechanism has not been elucidated yet.Objectives.The microRNA (miR)-let-7i plays an important regulatory role cardiovascular system and is widely involved cell proliferation apoptosis.In this study, we aimed investigate its functional roles apoptosis. Materials methods.Apoptosis was detected using TUNEL...
The effect of heart transplantation (HTx) on the pharmacokinetics (PK) caspofungin is not well-characterized. aim this study was to investigate population PK in HTx and non-HTx patients identify covariates that may affect caspofungin.
To investigate the effect of heat inactivation (56℃for 30 min) SARS-CoV-2 on results therapeuticdrug monitoring (TDM) voriconazole by liquid chromatography tandem mass spectrometry (LC-MS/MS).
In this work, we present HiReview, a novel framework for hierarchical taxonomy-driven automatic literature review generation. With the exponential growth of academic documents, manual reviews have become increasingly labor-intensive and time-consuming, while traditional summarization models struggle to generate comprehensive document effectively. Large language (LLMs), with their powerful text processing capabilities, offer potential solution; however, research on incorporating LLMs...
This study aimed to prepare evodiamine-glycyrrhizic acid(EVO-GL) micelles enhance the anti-hepatic fibrosis activity of evodiamine. Firstly, EVO-GL were prepared with use thin film dispersion method. With particle size, encapsulation efficiency, loading capacity and solubility evodiamine as indexes, effect different factors on was observed screen optimal preparation methods process. Then pharmaceutical properties therapeutic effects by process evaluated CCl_4-induced hepatic fibrosis. The...
Pharmacy service is to provide individualized pharmaceutical care for patients, which should follow the current evidence-based pharmacy, and constantly verify evidence then produce new evidence. In care, differences are often found in efficacy adverse reactions of drugs among individuals, even within closely related patient's genetics, liver kidney functions, disease states, drug interactions. Back 1980s, therapeutic monitoring (TDM) has been applied routinely monitor blood concentration...
Pharmacy service is to provide individualized pharmaceutical care for patients, which should follow the current evidence-based pharmacy, and constantly verify evidence then produce new evidence. In care, differences are often found in efficacy adverse reactions of drugs among individuals, even within closely related patients' genetics, liver kidney functions, disease states, drug interactions. Back 1980s, therapeutic monitoring (TDM) has been applied routinely monitor blood concentration...