A5090218224- Infectious Diseases and Tuberculosis
- Acute Ischemic Stroke Management
- Orthopedic Infections and Treatments
- Neurological Disease Mechanisms and Treatments
- Tuberculosis Research and Epidemiology
- Cerebrovascular and Carotid Artery Diseases
- Spinal Fractures and Fixation Techniques
- Stroke Rehabilitation and Recovery
- Diagnosis and treatment of tuberculosis
- Advanced Polymer Synthesis and Characterization
- Venous Thromboembolism Diagnosis and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Malware Detection Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Spine and Intervertebral Disc Pathology
- Stress Responses and Cortisol
- Anesthesia and Neurotoxicity Research
- Scoliosis diagnosis and treatment
- Nuclear Receptors and Signaling
- Genomics, phytochemicals, and oxidative stress
- Polymer Surface Interaction Studies
- Adversarial Robustness in Machine Learning
- Antimicrobial Peptides and Activities
- Tryptophan and brain disorders
- Lipid metabolism and disorders
Hebei General Hospital
2012-2025
Queen's University
2022-2025
Hebei Medical University
2008-2024
Hospital of Hebei Province
2012-2024
Chinese People 's Liberation Army No. 85 Hospital
2024
South China University of Technology
2024
Chinese PLA General Hospital
2020-2023
State Key Laboratory of New Ceramics and Fine Processing
2022
Chinese People's Liberation Army
2022
Baoding People's Hospital
2022
Increasing evidence shows that oxidative stress and neuroinflammation play a crucial role in the pathology of vascular dementia (VD). Previously, we have found Dl-3-n-butylphthalide (NBP) has antioxidant anti-inflammatory activities VD, whereas little is known about its mechanism. Therefore, objective our study was to explore contribution nuclear factor erythroid-2 related 2 (Nrf2) NBP effects on activity mouse model VD. Our studies revealed could effectively mitigate cognitive deficits,...
The triglyceride-glucose (TyG) index has been proposed as a new marker for insulin resistance, which is associated with risk of major depressive disorder (MDD). This study aims to explore whether the TyG correlated MDD. In total, 321 patients MDD and 325 non-MDD were included in study. presence was identified by trained clinical psychiatrists using International Classification Diseases 10th Revision. calculated follows: Ln (fasting triglyceride [mg/dL] × fasting glucose [mg/dL]/2). results...
Background: High-resolution magnetic resonance vessel wall imaging (HRMR-VWI) is a promising technique for identifying intracranial vulnerable plaques beyond lumen narrowing. However, the association between HRMR-VWI characteristics and recurrent stroke remains uncertain. Aims: This study aimed to investigate ipsilateral in patients with symptomatic atherosclerotic steno-occlusive disease (ICAS). Methods: multicenter, observational recruited first-ever acute ischemic attributed ICAS (>50%...
Abstract Introduction Treatment strategies for depression based on interventions glucose and lipid metabolism disorders are receiving increasing attention. Investigating the mechanism of their antidepressant effect exploring new diagnostic therapeutic biomarkers have attracted Dulaglutide, a long‐acting GLP‐1 receptor agonist, has been reported to alleviate cognitive deficits neuronal damage. However, dulaglutide and, especially, underlying still poorly understood. In this study, we aimed...
Finding similar code is important for software engineering, defense of intellectual property, and security, one the increasingly common ways adversaries use to defeat detection through obfuscations such as transformation scattering they wish hide amongst long sequences. Moving far enough apart poses a specific challenge solutions with localized features (e.g., n-grams) or attention mechanisms parts are distributed beyond local context window. We introduce neural network solution pattern...
Fall risk prediction is crucial for preventing falls in patients with cerebral small vessel disease (CSVD), especially those gait disturbances. However, research this area limited, particularly the early, asymptomatic phase. Wearable sensors offer an objective method assessment. This study integrating wearable and machine learning, aimed to predict fall covert CSVD. We employed soft robotic exoskeleton (SRE) acquire characteristics surface electromyography (sEMG) system collect sEMG...
Retrospective study.To evaluate the clinical outcomes of 4 different procedures for treatment adjacent multisegmental spinal tuberculosis (AMSST) and to investigate selection strategy optimal procedure with respect focal characteristics.Because lack support anterior columns multiple segments, AMSST is thought confer high risks development kyphosis paraplegia. However, there are few reports regarding surgical have been investigated.From August 1999 June 2010, 48 patients were enrolled in this...
Summary Aims Diabetes mellitus increases the risk of stroke, but mechanisms are unclear. The present study tested hypothesis that diabetes disturbs brain microcirculation and susceptibility to cerebral damage in a middle artery occlusion ( MCAO ) model ischemia. Methods was induced by streptozocin mice expressing green fluorescent protein endothelial cells (Tie2‐ GFP mice). Four weeks later, they were subjected transient (20 min) . In vivo blood flow measured two‐photon laser‐scanning...
Statistical noise may degrade the x-ray image quality of digital radiography (DR) system.This corruption can be alleviated by extending exposure time detectors and increasing intensity radiation.However, in some instances, such as security check medical imaging examination, system demands rapid low-dose detection.In this study, we propose test a generative adversarial network (GAN) based denoising method.Images used study were acquired from system.Promising results have been obtained our...
Abstract Brain repair, especially axonal sprouting, is critical to restore motor function in disabled stroke patients. Liraglutide (LG) a new kind of long‐acting analogue glucagon‐like peptide‐1 (GLP‐1) and has potential protective effects stroke. The mitochondria participate brain repair after cerebral injury. However, the mechanism effect LG on its influence remains obscure. Here, focal cortical ischemic mice model, improved functional recovery promoted sprouting by restoring activities...
Preventing surgical site infections (SSIs) of implants has drawn significant attention in both basic and clinical research. Implants with convenient preparation methods intelligent drug release capabilities are highly needed to resist bacterial infection. Herein, we designed an drug-release system, which can be instantly incorporated during the process. The system involves β-glycerophosphate (β-GP) chitosan (CS) as a thermosensitive hydrogel for instant construction onto hyaluronic acid (HA)...
Software vulnerabilities have been posing tremendous reliability threats to the general public as well critical infrastructures, and there many studies aiming detect mitigate software defects at binary level. Most of standard practices leverage both static dynamic analysis, which several drawbacks like heavy manual workload high complexity. Existing deep learning-based solutions not only suffer capture complex relationships among different variables from raw code but also lack explainability...
Abstract **Ischemic stroke remains a leading cause of morbidity and mortality globally. Despite the advances in thrombolytic therapy, notably recombinant tissue plasminogen activator (rtPA), patient outcomes are highly variable. This study aims to introduce novel predictive model, Acute Stroke Thrombolysis Non-Responder Prediction Model (ASTN-RPM), identify patients unlikely benefit from rtPA within critical early recovery window. We conducted retrospective cohort at Baoding No.1 Central...
Abstract A series of well‐defined double hydrophilic graft copolymers, consisting poly( N ‐isopropylacrylamide)‐ b ‐poly(ethyl acrylate) (PNIPAM‐ ‐PEA) backbone and poly(2‐(diethylamino)ethyl methacrylate) (PDEA) side chains, were synthesized by successive atom transfer radical polymerization (ATRP). The was firstly prepared sequential ATRP ‐isopropylacrylamide 2‐hydroxyethyl acrylate at 25 °C using CuCl/tris(2‐(dimethylamino)ethyl)amine as catalytic system. obtained diblock copolymer...
Abstract Background DNA microarrays can detect tuberculosis and its multi-drug resistant form in M. isolates sputum specimens with high sensitivity specificity. However, no performance data currently exists for use spinal specimens. This study was aimed to assess the of CapitalBio™ microarray detection isoniazid (INH) rifampicin (RMP) resistance compared BACT/MGIT 960 system. Methods From March 2009 December 2011, 153 consecutive patients from Southwest Hospital, Chongqing clinically...
Abstract Many coating materials have been studied to prevent surgical site infections (SSIs). However, antibacterial on surfaces show weak adhesion using the traditional titanium (Ti) cage, resulting in low efficacy for preventing SSIs after spinal surgery. Herein, a 3D‐printed Ti cage combined with drug‐releasing system is developed situ drug release and bacteria killing, leading prevention of vitro vivo. First, designed prepared by Electron Beam Melting (EBM) method. Second, polyvinyl...