Macrophages (Mφs) are master regulators of the immune response and may serve as therapeutic targets in aging societies. This study aimed to determine function M1Mφ-exosomes (Exos) development osteoporosis (OP) involvement microRNA (miR)-98 dual specificity phosphatase 1 (DUSP1). A murine model OP was established using ovariectomies (OVX). Bone loss observed OVX-treated mice, manifested by reduced bone mineral density decreased number trabecula. The further aggravated treatment with...

Nanoparticles identifying bacteria and forming a bacterial extracellular trap (BET). LPS induced in situ transformation self-assembly of BET nanoparticles were shown to Gram-negative bacteria.

To evaluate the clinical outcomes of anterior and posterior instrumentation with different debridement graft fusion methods for multi-level contiguous thoracic spinal tuberculosis.We retrospectively evaluated 81 patients tuberculosis who underwent or combined debridement, decompression, from January 2002 to December 2012. All were divided into an group a group. In group, there 39 transthoracic debridement. 34 trans-costotransverse decompression strut grafting instrumentation, another 8 in...

Preventing surgical site infections (SSIs) of implants has drawn significant attention in both basic and clinical research. Implants with convenient preparation methods intelligent drug release capabilities are highly needed to resist bacterial infection. Herein, we designed an drug-release system, which can be instantly incorporated during the process. The system involves β-glycerophosphate (β-GP) chitosan (CS) as a thermosensitive hydrogel for instant construction onto hyaluronic acid (HA)...

To investigate surgical methods and outcomes in the treatment of spinal tuberculosis (TB) adults.One hundred eighty-one patients (average age 39 years) without multiple-level noncontiguous TB were followed up for 22-72 months. The divided into four groups according to procedure on basis position extension foci: group A (74 cases): anterior radical debridement strut grafting with instrumentation; B (83 posterior instrumentation bone a single- or two-stage procedure; C (10 extrapleural...

Abstract Many coating materials have been studied to prevent surgical site infections (SSIs). However, antibacterial on surfaces show weak adhesion using the traditional titanium (Ti) cage, resulting in low efficacy for preventing SSIs after spinal surgery. Herein, a 3D‐printed Ti cage combined with drug‐releasing system is developed situ drug release and bacteria killing, leading prevention of vitro vivo. First, designed prepared by Electron Beam Melting (EBM) method. Second, polyvinyl...

A chitosan-coated pressed calcium sulfate pellet combined with recombinant human bone morphogenetic protein 2 (rhBMP-2) has been developed increased compressive strength and osteoinduction, but a resorption profile only slightly slower than uncoated pellet. radial segmental defect model of rabbit was used to study the restoration effect on treated rhBMP-2, coated pellet, Nothing implanted in control group. After 4, 8, 12 weeks, results indicated that rhBMP-2 facilitated new formation...

Purpose: The aim of this study was to investigate the clinical effectiveness azygos vein preservation when using a thoracoscope in operation for type III esophageal atresia children. Materials and Methods: We retrospectively analyzed data 34 patients (group B) who underwent thoracoscopic with from January 2017 April 2018. 36 A) mutilation 2015 December 2016 were selected as control group. Results: All successfully operated on. There no significant difference time, amount bleeding, mechanical...

Lidocaine, a potent local anesthetic, is clinically used in nerve block and pain management. However, due to its short half-life, repeated administration required. For this reason, here we designed prepared lidocaine-encapsulated polylactic acid-glycolic acid (Lidocaine@PLGA) microcapsule with ultrasound responsiveness relieve the sciatica pain. With premixed membrane emulsification strategy, fabricated lidocaine-embedded microcapsules possessed uniform particle size, good stability,...

Purpose This study aimed to identify the common pathways and hub genes related oxidative stress (OS) autophagy of both annulus fibrosus (AF) nucleus pulposus (NP) in intervertebral disc degeneration (IDD) based on data obtained from Gene Expression Omnibus (GEO) database. Methods The expression for human discs was GEO database, including AF NP non-degenerated degenerated disc. differentially expressed (DEGs) were identified using limma package R language. DEGs OS Ontology (GO) Analyses GO,...

Abstract Background This study was designed to summarize the clinical outcomes of transverse preputial island flap urethroplasty for single-stage correction proximal hypospadias in our hospital. Method retrospectively analysed data, including preoperative general information, intraoperative and postoperative follow-up 155 children with who were admitted hospital from January 2009 2019. Results During follow-up, a total 92 complications occurred, 41 patients underwent reoperation. There 49...

Abstract The objective was to explore the efficacy of single-port laparoscopic percutaneous extraperitoneal closure using double-modified hernia needles with hydrodissection (SLPEC group) and two-port (TLPEC for treatment giant indirect inguinal hernias in children. We performed a retrospective review all children (inner ring orifice diameter ≥ 1.5 cm) who underwent high ligation sac at FuJian Children’s Hospital from January 2019 December 2021. collected data medical records analysed their...

Purpose: Thoracic paravertebral block (TPVB) may be highly beneficial for thoracoscopic lobectomy patients, but it increase the risk of hypothermia. Apart from its anesthetic-reducing effects, this randomized controlled trial aimed to investigate hypothermic effect TPVB, and thus optimize clinical use. Patients methods: Adult patients were randomly allocated two groups: TPVB + general anesthesia (GA) group or GA group. In TPVB+GA group, was performed after induction by an experienced...

Abstract Purpose The purpose of this study was to investigate the effectiveness and safety operation for type III esophageal atresia using a thoracoscope. Methods clinical data 92 patients with in our hospital from January 2015 December 2018 were analyzed retrospectively. There 49 group A who underwent thoracoscopic surgery 43 B conventional surgery. Results mechanical ventilation time (55.7 ± 11.4 h vs 75.6 19.2 h), intensive care (3.6 1.8d 4.7 2.0d), postoperative hospitalization (13.1...

BACKGROUND:This study aimed to investigate the safety and effectiveness of laparoscopic pyloromyotomy for infants with congenital hypertrophic pyloric stenosis. MATERIAL AND METHODS:The clinical data 233 stenosis who were treated at our hospital from January 2013 2018 analyzed retrospectively. The patients divided into 2 groups: group (group A, n=126) conventional operation B, n=107). RESULTS:Laparoscopic surgery was successfully performed in all group, none surgeries converted open surgery....

The aim of this study was to investigate the safety and clinical efficacy mini-laparoscopic pyeloplasty in treating ureteropelvic junction obstruction (UPJO) infants.We retrospectively analysed data 66 infants with UPJO from January 2013 August 2018 at our hospital. They were divided into laparoscopic surgery group (group A) open B), depending on surgical method.The bleeding volume, analgesia duration, postoperative hospitalization incision length A significantly less than those B (p < .05)....

The purpose of this study was to summarize our clinical experience with transscrotal transverse incision in the treatment low and middle cryptorchidism children.A total 796 children or participated from March 2012 May 2018. Transscrotal used treat cryptorchidism. Symptoms signs were followed up at 1 week, month, 3months every six 12 months thereafter.Testicular descent fixation through scrotal successfully performed all children. All patients discharged 1-2 days after operation. During...

To compare the impact of scrotal vs inguinal orchidopexy approach on testicular function infants with cryptorchidism, a randomized controlled trial was conducted involving boys who were 6-12 months old at surgery and diagnosed clinically palpable, undescended testis. Between June 2021 December 2021, these Fujian Maternity Child Health Hospital (Fuzhou, China) Children's enrolled. Block randomization 1:1 allocation ratio employed. The primary outcome assessed by volume, serum testosterone,...

Abstract Background The purpose of this study was to investigate the clinical effect minimally invasive surgery for inguinal cryptorchidism. Methods patients were divided into group (n = 100) and traditional 58). In group, with low cryptorchidism 54) underwent a transscrotal incision, high 46) laparoscopic surgery. Results There no difference in hospital stay duration or cost between (P &gt; 0.05). As operative time, shorter than 0.033), while comparable 0.658). Additionally, there cases...

There are no ideal plates or approaches for anatomical restoration and rigid fixation of posterolateral tibial plateau fractures. This study aimed to evaluate the short-term preliminary outcomes our novel plate placed via trans-supra-fibular approach treat

Calcium sulfate has a rapid degradation rate and little osteoinductive capability. Chitosan-coated pressed calcium pellets combined with recombinant human bone morphogenetic protein 2 (rhBMP-2) have been developed that exhibit decreased resorption speed increased compressive strength osteoinduction. A rabbit femoral condyle-contained defect model was used to study the restoration of defects treated chitosan-coated rhBMP-2, pellets, uncoated pellets. No were implanted in control group. After...