Macrophages (Mφs) are master regulators of the immune response and may serve as therapeutic targets in aging societies. This study aimed to determine function M1Mφ-exosomes (Exos) development osteoporosis (OP) involvement microRNA (miR)-98 dual specificity phosphatase 1 (DUSP1). A murine model OP was established using ovariectomies (OVX). Bone loss observed OVX-treated mice, manifested by reduced bone mineral density decreased number trabecula. The further aggravated treatment with...

Introduction Stroke patients with hemiplegia are at an increased risk of falling during sit-to-stand (Si-St) and stand-to-sit (St-Si) tasks, partly due to impaired bilateral lower limb symmetry. Maintaining symmetrical movement between the limbs in these tasks can help reduce fall incidence. Method This study aimed investigate symmetry Si-St St-Si stroke compare their performance healthy controls. Thirteen 13 controls participated study. Participants were instructed perform 30-s chair stand...

The members of the integrin αv (ITGAV) family are widely expressed on many types tumors and have been reported to be involved into angiogenesis, tumor metastases, multicellular radioresistance. Osteosarcoma (OS) is most common primary malignant bone role ITGAV in OS needs further elucidated. MicroRNAs aberrantly a variety cancers. Thus, authors collected tissues (n = 15) corresponding paracancerous found that expression miR-548c-3p was significantly downregulated cell lines 143B, SaoS2, HOS...

Rheumatoid arthritis (RA) is a worldwide chronic autoimmune inflammatory disease which affecting approximately 1% of the total population. It characterized by abnormal proliferation fibroblast-like synoviocytes (FLS) and increased production proinflammatory cytokines. In current study, we were aiming to investigate role ubiquitin-specific protease 5 (USP5) in process RA-FLS. Expression USP5 was found upregulated RA-FLS compared with that osteoarthritis- (OA-) FLS, IL-1 β stimulation...

The aim of the present study was to evaluate anti‑aging effects bone marrow‑mesenchymal stem cells (BM‑MSCs) in a D‑galactose-induced skin aging rat model. Male Sprague Dawley rats were randomly divided into four groups (n=10/group) as follows: Normal control group; model MSC‑treated group by subcutaneous multi‑point injection. established daily injection 15% D‑galactose (1,000 mg/kg) for 8 weeks. Rats administered 3x106/ml BM‑MSCs/green fluorescent protein (GFP) 4 weeks, once per week....

Epigallocatechin‑3‑gallate (EGCG) is a polyphenolic compound extracted and isolated from green tea, which has variety of important biological activities in vitro vivo, including anti‑tumor, anti‑oxidation, anti‑inflammation lowering blood pressure. The aim the present study was to investigate protective effect EGCG against secondary osteoporosis mouse model via Wnt/β‑catenin signaling pathway. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blotting were used...

It has been reported that tetrahydrocurcumin hypoglycemic, hypolipidemic, anti‑metastasis, anticancer and anti‑depressant pharmacological effects, its antioxidative, hypoglycemic hypolipidemic properties are better than those of curcumin. The present study assessed whether exerts a neuroprotective effect against spinal cord injury (SCI) investigated the underlying mechanisms. In rat model SCI, enhanced average Basso‑Beattie‑Bresnahan scores, inhibited water accumulation in decreased...

The present study aimed to determine the mechanisms of action curcumin in osteosarcoma. Human osteosarcoma U-2 OS cells was purchased from Cell Bank Chinese Academy Sciences. RNA sequencing analysis performed for 2 curcumin-treated samples and control using Illumina deep technology. differentially expressed genes were identified Cufflink software. Enrichment protein-protein interaction network analyses separately cluster Profiler package Cytoscape software identify key genes. Then, mRNA...

Modern pharmacological studies revealed that Celastrol exhibits anti‑inflammation, anti‑bacteria, anti‑virus, anti‑fertility, insect‑resistance functions and has been used for the treatment of rheumatism, rheumatoid arthritis, blood diseases, skin diseases agricultural insecticide. The present study aimed to investigate effects on glucocorticoid‑induced osteoporosis (GIOP) underlying molecular mechanisms. findings current reduced body weight, urine calcium/creatinine, tartrate‑resistant acid...

Tuberculous sacroiliitis with abscess accounts for approximately 50 % of all sacroiliac joint tuberculosis cases. abscesses spread into the capsule, subcutaneous tissue, and skin, finally becomes a skin sinus. As there are no previous reports about chronic sinus, we evaluated its clinical characteristics management by negative pressure wound therapy.

Synergistic mild photothermal/nanozyme therapy with outstanding hyperthermia performance and excellent multienzyme properties is highly needed for osteosarcoma treatment. Herein, we have developed efficient single-atom nanozymes (SANs) consisting of Mn sites atomically dispersed on nitrogen-doped carbon nanosheets (denoted as Mn-SANs) synergistic photothermal/multienzymatic against osteosarcoma. Benefiting from their black N-doped nanosheet matrices, Mn-SANs showed an NIR-II-triggered...

Abstract The developing a green and facile synthetic approach of Ag-based antibacterial nanomaterials with controlled composition, size, shape, to acquire high activity long-term durability, is vital importance remains challenging goal. Herein, novel LDHs-supported Ag nanomaterial (Ag/CoAl-LDHs) are fabricated via an in situ deposition the nanoparticles onto CoAl-LDHs surface. X-ray diffraction pattern (XRD) High-resolution TEM (HRTEM) measurements confirm that uniform (the average particle...

A simple modeling and simulation method of sea clutter for missile-borne high-resolution radar is presented by introducing the K distribution sequences to represent characteristics amplitude fluctuation correlation cells. Its model parameters implementation steps are discussed in detail. The was performed after elaborately setting environment parameters. Simulation results show that effective, provides a feasible engineering radar.

Advancements in the study of refractory insomnia suggest a paradigm shift modern treatment methodologies towards diversification and personalization. Traditional pharmacotherapies, such as benzodiazepines, are noted for their dependency risks. However, new-age drugs like Dexmedetomidine garnering attention safety profile protective effects on sleep architecture. Cognitive Behavioral Therapy (CBT), non-pharmacological intervention, has proven effective, though it requires long-term...

Objective To assess the performance of Xpert MTB/RIF system in detection tuberculosis and its rifampicin resistance form spinal specimens.Methods From June 2009 to December 2012,140 specimens selected from tissue bank The 309th Hospital PLA were enrolled into this study.Specimens proprocessed subjected M.tuberculosis by MTB/RIF,and results compared with those obtained cultivation absolute concentration drug susceptibility testing tell sensitivity,specificity,95％ confidence interval...

Abstract Objective The prognostic markers of hepatocellular carcinoma (HCC) patients with bone metastasis are great significance for the design treatment strategy, maintenance life quality patients, and improvement cancer prognosis. MicroRNA-149 (miR-149) rs2292832 C/T polymorphism in HCC has been reported to be associated risk HCC, but whether it can predict prognosis remains unclear. goal our study was examine impact miR-149 on metastasis. Methods A total 67 cases (BC group) 73 without (NC...

Semi-synthesis of natural products has been considered to be an optional method for providing more active and less toxic derivatives establishment structure-activity relationships (SAR). The genus Zanthoxylum is a rich source benzophenanthridine-type alkaloids. In our search antimycobacterial constituents from medicinal plants, we have extensively investigated the African plant capense, which led isolation twenty-seven compounds most them Benzophenanthridine alkaloids were found various...

Hyperlipidemia is not unusual in liver transplant recipients, but refractory severe hyperlipidemia unusual. We treated a 39-year-old man who had dyslipidemia after transplant. The levels of blood lipids, enzymes, and essential indicators pathology were monitored. first serum sample was collected from the recipient 56 days surgery because samples could be obtained sooner enzymes lipids improved with symptomatic treatment recurrent fluctuations. Tacrolimus cyclosporine, even at low doses, may...