A5101661947- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Hip and Femur Fractures
- Pelvic and Acetabular Injuries
- Bone Metabolism and Diseases
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Orthopedic Infections and Treatments
- Foot and Ankle Surgery
- Bone fractures and treatments
- Bone health and osteoporosis research
- Orthopedic Surgery and Rehabilitation
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Diabetic Foot Ulcer Assessment and Management
- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Shoulder and Clavicle Injuries
- Cytokine Signaling Pathways and Interactions
- Spinal Fractures and Fixation Techniques
- Extracellular vesicles in disease
- Cardiac Valve Diseases and Treatments
- Metastasis and carcinoma case studies
- Spinal Cord Injury Research
- Cancer-related molecular mechanisms research
Peking University
2024
Peking University International Hospital
2024
XinHua Hospital
2014-2023
Shanghai Jiao Tong University
2009-2023
Union Hospital
2022
Huazhong University of Science and Technology
2022
Shanghai University of Medicine and Health Sciences
2019-2021
Wuhan University of Science and Technology
2021
Ningbo No.6 Hospital
2020
Renji Hospital
2020
ABSTRACT Emerging evidence indicates that microRNAs (miRNAs) play essential roles in regulating osteoblastogenesis and bone formation. However, the role of miRNA osteoblast mechanotransduction remains to be defined. In this study, we aimed investigate whether miRNAs regulate mechanical stimulation–triggered differentiation formation through modulation Runx2, master transcription factor for osteogenesis. We first investigated loading both a mouse model an culture system outcomes clearly...
Abstract Introduction Programmed cell death of intervertebral disc (IVD) cells plays an important role in IVD degeneration, but the autophagy, a closely related event, has not been documented. The current study was designed to investigate effect interleukin (IL)-1β on occurrence autophagy rat annulus fibrosus (AF) and interrelationship between apoptosis. Methods Rat AF were isolated exposed, tissue cultures with or without serum, IL-1β different concentrations for 24 hours. Ultrastructural...
Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP-2 pathway has been well-defined as a vital positive modulator of Gremlin2 (Grem2) is morphogenetic protein (BMP) antagonists. However, effect Grem2 on BMP-2-induced osteogenesis human marrow-derived mesenchymal stem cells (hBMSCs) remains ambiguous. This study aimed to analyze procedure in vitro vivo. The differentiation hBMSCs was...
Emerging data has suggested a high prevalence of osteoarthritis (OA) among obese people. As an important adipokine secreted by white adipose tissue, leptin may be key mediator in the progression OA. Leptin exerts catabolic effect on OA cartilage increasing production metalloproteinase (MMP) enzymes, and contributes to apoptosis chondrocytes. The current study aimed explore role chondrocytes OA, its underlying mechanisms. In vitro model used present study, administration exogenous induced...
It is widely accepted that mechanical stress an important factor in bone associated cell differentiation, including of mesenchymal stem cells, osteoblasts and osteocytes. The present study aimed to determine the effect cyclic compressive load on osteoblast whether this was with activation wingless‑type (Wnt)/β-catenin signaling pathway. Using a 3D scaffold model, MC3T3‑E1 cells were exposed loading via Flexcell‑5000C™ Compression system. Sinusoidal wave magnitudes 0.33, 0.5 1 MPa applied for...
Osteoarthritis (OA) is a common and dynamic joint disease, including the articular cartilage, underlying bones, synovium. In particular, OA considered as degeneration of cartilage. Tectorigenin (Tec) can affect many biological processes. However, its effect on chondrocytes remains unclear. This study aimed to assess role Tec in vitro, inhibited expression levels type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3, MMP-13 gene but enhanced those Runx1, II aggrecan presence...
Abstract Developmental dysplasia of the hip (DDH) is a developmental disorder that has long‐term chronic pain and limited joint mobility as major pathological characteristics. This study aims to access association between development DDH cartilage metabolic disorders. Cartilage tissue samples were acquired from patients with DDH, osteoarthritis (OA) femoral neck fracture. The proteoglycan level was evaluated by safranin O‐fast green, toluidine blue hematoxylin‐eosin (HE) staining. levels...
Osteoarthritis (OA) is one of the most prevalent chronic joint diseases while precise genetic mechanism remains elusive. In this study, we investigated gene expression profile in OA by microarray analysis. Histopathological characteristics cartilage were examined using a rat model leptin-induced OA. Gene articular and healthy compared genome-wide hybridization. A total 1857 genes differentially expressed (1197 upregulated 660 downregulated) identified, some which are known to be associated...
The tachykininergic neurotransmitters have been proved to be involved in the inflammatory progress and chronic pain series of disease. present study was undertaken evaluate levels substance P (SP) its receptors NK-1 receptor (NK-1R) both serum synovial tissues hip joint from patients with different stages DDH, detect possible correlation SP sensation dysfunction joint.SP DDH combined osteoarthritis (DDH&OA) group were compared through immunohistochemistry (IHC), ELISA, 2-step acetic acid...
As a recognized cause of groin pain following total hip arthroplasty, iliopsoas tendonitis probably results from different factors. Given the anatomic disadvantage, dysplastic hips theoretically make acetabular component relatively retroverted or oversized, screws implanted frequently, and more likely. However, prevalence mechanism replacement in are not fully understood.One hundred thirty-three arthroplasties for Crowe type 2 to 4 were compared with 126 without dysplasia this study....