A5007709310- Orthopaedic implants and arthroplasty
- Hip disorders and treatments
- Orthopedic Infections and Treatments
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Bone Metabolism and Diseases
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Spinal Fractures and Fixation Techniques
- Pelvic and Acetabular Injuries
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Immune cells in cancer
- Vascular Tumors and Angiosarcomas
- Vascular Malformations and Hemangiomas
- Bone fractures and treatments
- Spine and Intervertebral Disc Pathology
- Orthopedic Surgery and Rehabilitation
- Anesthesia and Pain Management
- Bone Tissue Engineering Materials
- Anesthesia and Sedative Agents
- Cervical and Thoracic Myelopathy
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- Autophagy in Disease and Therapy
XinHua Hospital
2015-2024
Shanghai Sixth People's Hospital
2008-2024
University Hospital of Wales
2024
Zhejiang University
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2016-2024
Shanghai Jiao Tong University
2013-2023
Suizhou Central Hospital
2022
Weatherford College
2022
Bengbu Medical College
2020
ABSTRACT Emerging evidence indicates that microRNAs (miRNAs) play essential roles in regulating osteoblastogenesis and bone formation. However, the role of miRNA osteoblast mechanotransduction remains to be defined. In this study, we aimed investigate whether miRNAs regulate mechanical stimulation–triggered differentiation formation through modulation Runx2, master transcription factor for osteogenesis. We first investigated loading both a mouse model an culture system outcomes clearly...
Crosstalk between nerves and bone is essential for repair, which Schwann cells (SCs) are crucial in the regulation of microenvironment. Considering that exosomes critical paracrine mediators intercellular communication exert important effects tissue aim this study to confirm function molecular mechanisms cell-derived (SC-exos) on regeneration propose engineered constructs simulate SC-mediated nerve–bone crosstalk. SCs promoted proliferation differentiation marrow mesenchymal stem (BMSCs)...
Osteoblasts are essential for maintaining skeletal architecture and modulating bone microenvironment homeostasis. From numerous associated investigations, the BMP-2 pathway has been well-defined as a vital positive modulator of Gremlin2 (Grem2) is morphogenetic protein (BMP) antagonists. However, effect Grem2 on BMP-2-induced osteogenesis human marrow-derived mesenchymal stem cells (hBMSCs) remains ambiguous. This study aimed to analyze procedure in vitro vivo. The differentiation hBMSCs was...
Sr incorporated scaffolds promote the polarization of neutrophils to N2 phenotype through STAT3 activation and inhibition NF-κB signal pathway, which induced M2 macrophage differentiation, inflammation resolution angiogenesis.
Background: Skeletal unloading usually induces severe disuse osteoporosis (DOP), which often occurs in patients subjected to prolonged immobility or spaceflight astronauts. Increasing evidence suggests that exosomes are important mediators maintaining the balance between bone formation and resorption. We hypothesized play an role maintenance of homeostasis through intercellular communication marrow mesenchymal stem cells (BMSCs) osteoclasts under mechanical loading.Methods: Cells were...
BACKGROUND The study aimed to develop a novel orthopedic surgical scaffold made of collagen and silk repair the tendon bone interface, investigate its influence on healing in rabbit model. MATERIAL AND METHODS Four types were prepared, including random (RCS), an aligned (ACS), combined with knitted (RCSS), (ACSS). Rabbit marrow stem cells (BMSCs) cultured seeded onto RCS ACS scaffold. animal model included four-month-old female New Zealand White rabbits (N=20) that underwent drilling into...
Osteoarthritis (OA) is a common degenerative disease in middle-aged and elderly people. Our previous study has proved that microRNA-7 (miR-7) exacerbated the OA process. This was aimed to explore downstream genes mechanism regulated by miR-7 affect OA. Multiple EGF-like-domains 9 (MEGF9) predicted target of databases. Luciferase report experiment results confirmed MEGF9 could bind miR-7. Among 10 collected pairs healthy samples, expression levels were both up-regulated when compared with...
Increasing evidence suggests that chronic stress increases pain sensitivity and exacerbates existing pain. However, whether how unpredictable (CUS) affects surgical is unclear.A postsurgical model was performed by longitudinal incision from 0.3 cm of the proximal edge heel toward toes. The skin sutured, wound site covered. Sham surgery groups underwent same procedure without an incision. short-term CUS conducted exposure mice to 2 different stressors each day for 7 days. behavior tests were...
Abstract Aseptic loosening is mainly caused by wear debris generated friction that can increase the expression of receptor activation nuclear factor (NF)-κB (RANKL). RANKL has been shown to support differentiation and maturation osteoclasts. Although autophagy a key metabolic pathway for maintaining homeostasis cells, no study determined whether induced Al 2 O 3 particles involved in pathogenesis aseptic loosening. The aim this was evaluate levels patients experiencing after total hip...
Mechanical factors are related to periprosthetic osseointegration following total hip arthroplasty. However, osteoblast response strain in implanted femurs is unclear because of the absence accurate stress-measuring methods. In our study, finite element analysis was performed calculate distribution femurs. 0.8-3.2% tensile then applied human osteoblasts. Higher magnitudes enhanced expression osteocalcin, type I collagen, and Cbfa1/Runx2. Lower significantly increased ALP activity. Among...
Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder characterized by progressive joint soreness and limited mobility. The aim present study was to investigate pathological changes inflammatory infiltration in hypertrophic synovium associated with progression DDH. Synovial biopsies are obtained from patients moderate DDH severe during surgery. These processed for histological immunohistochemical (IHC) analysis investigation processes synovium, including types cell...
Hemolymphangioma is a rare vascular developmental error. It comprises malformed venous and lymphatic component in various proportion. To the best of our knowledge, only few cases have been reported literature so far. Here, we report case huge intraperitoneal cystic mass 3-year-old boy that was presented to hospital with intractable abdominal pain. On examination, he had fever along associated symptoms like cough sputum. Abdomen distended no tenderness or rebound tenderness. computed...
Osteoarthritis (OA) is a common and dynamic joint disease, including the articular cartilage, underlying bones, synovium. In particular, OA considered as degeneration of cartilage. Tectorigenin (Tec) can affect many biological processes. However, its effect on chondrocytes remains unclear. This study aimed to assess role Tec in vitro, inhibited expression levels type X collagen, cyclooxigenase-2, matrix metalloproteinase (MMP)-3, MMP-13 gene but enhanced those Runx1, II aggrecan presence...
Abstract Developmental dysplasia of the hip (DDH) is a developmental disorder that has long‐term chronic pain and limited joint mobility as major pathological characteristics. This study aims to access association between development DDH cartilage metabolic disorders. Cartilage tissue samples were acquired from patients with DDH, osteoarthritis (OA) femoral neck fracture. The proteoglycan level was evaluated by safranin O‐fast green, toluidine blue hematoxylin‐eosin (HE) staining. levels...
Abstract Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases. The present study aimed to identify hub genes involved in the pathogenesis further explore potential treatment targets RA OA. Methods: gene expression profile GSE12021 was downloaded from Gene Expression Omnibus (GEO). Total 31 samples (12 RA, 10 OA 9 NC samples) were used. differentially expressed (DEGs) versus NC, groups screened using limma package. We also verified DEGs GSE55235...
The tachykininergic neurotransmitters have been proved to be involved in the inflammatory progress and chronic pain series of disease. present study was undertaken evaluate levels substance P (SP) its receptors NK-1 receptor (NK-1R) both serum synovial tissues hip joint from patients with different stages DDH, detect possible correlation SP sensation dysfunction joint.SP DDH combined osteoarthritis (DDH&OA) group were compared through immunohistochemistry (IHC), ELISA, 2-step acetic acid...
Abstract Acute myeloid leukaemia (AML) is a frequently fatal malignant disease of haematopoietic stem and progenitor cells. The molecular phenotypic characteristics AML are highly heterogeneous. Our previous study concluded that CaMKIIγ was the trigger chronic progression from phase to blast crisis, but how influences stem‐like cells remains elusive. In this study, we found overexpressed in patients cell lines, as measured by qRT‐PCR Western blot assays. Moreover, decreased when remission....
Most distal radius fractures are associated with ulnar fractures. However, there is still a lack of consensus on the incidence different types among adults in China. Therefore, we analyzed radial and without southern China county from 2010 to 2020. Registry data 2333 patients (2351 sides) fracture 2020 underwent evaluation, encompassing parameters such as age, sex, classification, side, classification. Distal were classified according AO/OTA examined using Q-modifier 1719 females (73.68%)...
Aseptic loosening is a major complication of joint replacement surgery, characterized by periprosthetic osteolysis and chronic inflammation at the bone‑implant interface. Cells release chemokines, cytokines other pro‑inflammatory substances that perpetuate reactions, while particle‑stimulated macrophages promote osteoclastic bone resorption impair formation. The present study investigated integrin inflammatory cytokine expression patterns in RAW 264.7 cells treated with titanium (Ti)...