A5101961988- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Osteoarthritis Treatment and Mechanisms
- Connective Tissue Growth Factor Research
- Nanoplatforms for cancer theranostics
- Bone Metabolism and Diseases
- Immune cells in cancer
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Bone health and treatments
- Histone Deacetylase Inhibitors Research
- Vitamin K Research Studies
- Macrophage Migration Inhibitory Factor
- Reproductive Physiology in Livestock
- Mycobacterium research and diagnosis
- Congenital Ear and Nasal Anomalies
- Reproductive tract infections research
- Cancer-related Molecular Pathways
- Bone Tissue Engineering Materials
- Sarcoma Diagnosis and Treatment
- interferon and immune responses
- Estrogen and related hormone effects
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2015-2024
Xiangya Hospital Central South University
2019
Changsha University
2017
Recently, emerging evidence has demonstrated that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNAs (lncRNAs), contributes to the initiation and development of tumors, including osteosarcoma (OS). Multiple studies have suggested an oncogenic role MALAT1 high-mobility group protein B1 (HMGB1) in OS tumorigenesis metastasis, but effects mechanisms are not unanimous. Here, we showed HMGB1 were significantly increased human cell lines knockdown reduced...
Sr incorporated scaffolds promote the polarization of neutrophils to N2 phenotype through STAT3 activation and inhibition NF-κB signal pathway, which induced M2 macrophage differentiation, inflammation resolution angiogenesis.
Abstract Bone marrow mesenchymal stem cell (BMSC)-derived exosomes have been found to enhance fracture healing. In addition, microRNAs contributing the healing of various bone fractures attracted widespread attention in recent years, but knowledge mechanisms by which they act is still very limited. this study, we clarified function altered microRNA-19b (miR-19b) expression BMSCs We modulated miR-19b via mimics/inhibitors and agomirs mice explore effects these changes on osteogenic factors,...
The present study aimed to investigate the role and mechanism of action microRNA (miR)-26a in deep vein thrombosis (DVT). Peripheral blood was collected from 45 patients with DVT 40 healthy controls. Levels miR-26a, chemokine C-C motif ligand (CCL)2 mRNA CCL7 were detected using reverse transcription-quantitative polymerase chain reaction value miR-26a clinical diagnosis assessed receiver operating characteristic curve analysis. correlation CCL2 levels analyzed Spearman's rank correlation....
Abstract This study aimed to investigate the mechanism of ubiquitinase Aurora kinase A (AURKA) in occurrence osteoarthritis (OA) by mediating mitochondrial stress. Bioinformatic predictions revealed 2247 differentially expressed genes (DEGs) normal and OA tissues. According UbiNet database, 39 DEGs that code for ubiquitination enzymes was screened. AURKA highly tissues cells. interference inhibited elevation matrix metalloproteinase‐13 (MMP‐13). (MMP13), sex determining region Y‐box 9...
Abstract Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors. The degradation of aggrecan upregulated ADAMTS (a disintegrin and metalloproteinase thrombospondin motifs) key event in development OA. ADAMTS‐4 contributes to human Cysteine‐rich angiogenic inducer 61 (Cyr61), which associated diseases related chronic inflammation, found articular cartilage from patients osteoarthritis appears suppress activity, possibly leading...
Sexually transmitted infection with Chlamydia trachomatis may lead to fibrotic blockage in women’s upper genital tracts, resulting tubal infertility. Intravaginal inoculation C. muridarum readily induces or hydrosalpinx mice and is used for investigating pathogenicity.
This study aimed to investigate the effect of long non-coding TDRG1 on proliferation and migration osteosarcoma cells through PI3K/AKT signaling pathway. Altogether 87 cases tissues adjacent were collected, osteoblasts purchased. The expression LncRNA in was detected by RT-PCR. Si-NC, si-TDRG1, Sh-TDRG1 transfected into cells. L740Y-P (activator pathway) LY294002 (inhibitor PI3k/AKT used interfere with PI3k/Akt pathway qRT-PCR detect WB p-PI3K, p-AKT, N-cadherin, E-Cadherin, vimentin, Bax,...
Previous studies have shown that protein inhibitor of activated STAT (PIAs)xα is crucial in sumoylation and associated with cancer cell progression. However, the mechanism underlying inhibitory effect on cells, which may assist developing novel treatment strategies remains to be elucidated. In present study, expression levels PIAsxα from tissue samples osteosarcoma adjacent tissues 25 patients were analyzed using reverse transcription‑quantitative polymerase chain reaction, western blot...
Simvastatin is demonstrated to be a potent stimulator for bone formation.
OBJECTIVE To investigate the effect of miR-30a/HMGA2-mediated autophagy in osteosarcoma cells on apoptosis induced by chemotherapeutics. Methods: A total 30 tissues sensitive and resistant to chemotherapeutics were divided into a chemotherapy-sensitive group chemotherapy-resistant group. The mRNA expression levels miR-30a high mobility protein A2 (HMGA2) group, U2-OS treated cisplatin, doxorubicin methotrexate at different concentrations detected real-time PCR. related Beclin 1, microtubule...
It is well established that glucocorticoid-induced osteoporosis highly associated with preosteoblast differentiation and function. This study based on the premise Wnt7b can promote bone formation through Wnt signalling pathway because it stimulate increase its activity. However, unknown whether rescue inhibited osteoblast function caused by exogenous glucocorticoid.In this we used overexpression ST2 cells to explore Wnt7bcan function, which provide strong proof investigate a new drug for...