A5103264701- Lung Cancer Research Studies
- Cancer Mechanisms and Therapy
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Inflammatory mediators and NSAID effects
- Glycosylation and Glycoproteins Research
- Microbial Natural Products and Biosynthesis
- Bone and Joint Diseases
- Cell Adhesion Molecules Research
- Immune cells in cancer
- Helicobacter pylori-related gastroenterology studies
- Hedgehog Signaling Pathway Studies
- Dermatological and COVID-19 studies
- Periodontal Regeneration and Treatments
- Metastasis and carcinoma case studies
- Gastroesophageal reflux and treatments
- Genetic factors in colorectal cancer
- Nanoplatforms for cancer theranostics
- Inflammatory Biomarkers in Disease Prognosis
- Hip and Femur Fractures
- Medical Research and Treatments
- Liver Disease and Transplantation
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Enzyme Production and Characterization
Shandong University
2023-2025
Soochow University
2012-2024
Fudan University
2023-2024
Zhongshan Hospital
2023-2024
State Key Laboratory of Microbial Technology
2023
Second Xiangya Hospital of Central South University
2021-2023
Central South University
2021-2023
Sun Yat-sen University
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Biotechnology Research Institute
2012
Responses toward preoperative chemotherapy are heterogeneous in patients with gastric adenocarcinoma. Existing studies the field focus heavily on tumor microenvironment (TME), whereas little is known about relationship between systemic immunity and response. In this study, we collect serum samples from adenocarcinoma before, on, after study their immune proteomics using an antibody-based panel. We also surgically resected incorporate multiple methods to assess TME. find that both local...
Myeloid-derived suppressor cells (MDSCs) significantly hinder the immune response to tumor radiotherapy (RT) because of their massive accumulation in tumors after RT, resulting immunosuppression and poor clinical prognosis. Herein, we developed an anti-PD-L1 antibody-conjugated iron oxide nanoprobe (Fe
Siderophores are ferric ion chelating natural products secreted by microorganisms to survive in an iron-deficient environment. During screening for siderophores from marine bacteria, four interconvertible ulbactins C1–C4 and oxidized derivatives were identified the bacterium Pseudoalteromonas flavipulchra S16. Iron-ion activity assays revealed that reduction of thiazoline rings is critical activity. The biosynthetic gene cluster (ubt) was genome P. S16 validated via knockout heterologous...
Numerous studies have reported the critical roles of long non‑coding RNAs (lncRNAs) in regulation osteoarthritis (OA) development. The present study aimed to assess function and regulatory mechanism a lncRNA, KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1), OA <em>in vitro</em>. C28/I2 cells were treated with lipopolysaccharide (LPS) generate an vitro</em> model. relative expression levels KCNQ1OT1, microRNA (miR)‑211‑5p transcription factor 4 (TCF4) determined via reverse...
Abstract Gastric cancer (GC), a molecularly and phenotypically highly heterogeneous malignancy, is leading cause of cancer-related deaths. The Cancer Genome Atlas (TCGA) project identifies the microsatellite instability (MSI) subtype GC, which has garnered increasing attention due to its relatively favorable survival outcome better response immune checkpoint inhibitors (ICIs). occurrence MSI closely associated with defects in mismatch repair system, subsequently accumulation mutations cell...
Recent studies have suggested that cartilage progenitor cells (CPCs) could be activated and differentiated into chondrocytes to produce matrix restore the integrity of damaged after injury. However, mechanism involved in CPC activation upon damage is still unclear. This study aims investigate role high mobility group box chromosomal protein 1 (HMGB1) both migration CPCs during injury.Explants harvested from mature bovine stifle joints were used for impact The proliferation examined via...
The development of a specific and noninvasive technology for understanding gastritic response together with efficient therapy is an urgent clinical issue. Herein, we fabricated novel iodinated bovine serum albumin (BSA) nanoparticle based on microenvironment computed tomography (CT) imaging repair acute gastritis. Derived from the characteristic mucosa defect inflammatory cell (e.g., macrophage neutrophil) infiltration in gastritis, pH-sensitive nanoparticles can sedimentate under acidic...
ABSTRACT Purpose The feasibility of transarterial infusion chemotherapy and embolization (TAICE) in the treatment advanced gastric cancer remains unclear. This study explored value TAICE patients with unresectable locally or metastatic stomach gastroesophageal junction (GEJ). Methods Patients who received for tumor hemorrhage cessation were enrolled this retrospective study. was performed using Seldinger method. feeding artery selected then embolized by microspheres gelatin sponge. involved...
It is well established that glucocorticoid-induced osteoporosis highly associated with preosteoblast differentiation and function. This study based on the premise Wnt7b can promote bone formation through Wnt signalling pathway because it stimulate increase its activity. However, unknown whether rescue inhibited osteoblast function caused by exogenous glucocorticoid.In this we used overexpression ST2 cells to explore Wnt7bcan function, which provide strong proof investigate a new drug for...
Objective: To investigate the feasibility of isolation and culture human adenoid-derived mesenchymal stem cells (aMSCs) in vitro, to observe differentiation aMSCs into olfactory sensory neurons. Methods: Adenoid tissues surgically removed from children with adenoid hypertrophy Second Xiangya Hospital Central South University September November 2020 were collected. The digested isolated by trypsin then cultured adhesion method. expressions cell surface antigens CD45, CD73 CD90 on P5...