A5050804010- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Antibiotic Resistance in Bacteria
- Neural dynamics and brain function
- Antibiotics Pharmacokinetics and Efficacy
- Epilepsy research and treatment
- Tuberculosis Research and Epidemiology
- Cancer therapeutics and mechanisms
- Neural and Behavioral Psychology Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiac electrophysiology and arrhythmias
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
Baylor College of Medicine
2017-2023
KCNQ2/3 channels, ubiquitously expressed neuronal potassium have emerged as indispensable regulators of brain network activity. Despite their critical role in homeostasis, the mechanisms by which dysfunction lead to hypersychrony are not fully known. Here, we show that deletion channels changed PV+ interneurons’, but SST+ firing properties. We also find either or KCNQ2 from interneurons led elevated homeostatic potentiation fast excitatory transmission pyramidal neurons. Pvalb-Kcnq2...
Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue emerge in response antibiotic use. β-Lactamases that hydrolyze last resort carbapenem class (carbapenemases) are a growing global health threat. Inhibitors have been developed prevent β-lactamase-mediated restore efficacy antibiotics. However, there few inhibitors available for problematic carbapenemases such as oxacillinase-48 (OXA-48). A DNA-encoded...
In two monogenic models of absence epilepsy, interictal beta/gamma power is augmented in homozygous stargazer (stg/stg) but not tottering (tg/tg) mice. There are distinct gene-linked patterns aberrant phase-amplitude coupling the EEG both stg/stg and tg/tg mice, compared to +/+ stg/+ Treatment with ethosuximide significantly blocks seizures genotypes, abnormal remains. Seizure-free mice have normal coupling, reduced NMDA receptor blockade, revealing a latent cortical network phenotype that...
β-Lactamase enzymes hydrolyze and thereby provide bacterial resistance to the important β-lactam class of antibiotics. The OXA-48 NDM-1 β-lactamases cause last-resort β-lactams, carbapenems, leading a serious public health threat. Here, we utilized DNA-encoded chemical library (DECL) technology discover novel β-lactamase inhibitors. We exploited enzyme–substrate binding interactions created DECL targeting carboxylate-binding pocket present in all β-lactamases. A 106 compounds, each...
Abstract Sustained attention is supported by circuits in the frontoparietal network. In human and primate studies, right posterior parietal cortex (PPC) shows dominance for sustained attention, phase-amplitude coupling (PAC) throughout network correlates with performance on tasks. Here we evaluate oscillatory dynamics of bilateral PPC mice during 5-Choice Serial Reaction Time Task (5-CSRTT). Right theta-gamma PAC (TG-PAC) gamma power were independently elevated to a greater degree than left...
Abstract Anti-seizure drug (ASD) targets are widely expressed in both excitatory and inhibitory neurons. It remains unknown if the action of an ASD upon neurons could counteract its beneficial effects on (or vice versa), thereby reducing efficacy ASD. Here, we examine whether retigabine (RTG) is altered after removal Kv7 potassium channel subunit KCNQ2, one targets, from parvalbumin-expressing interneurons (PV-INs). Parvalbumin-Cre (PV-Cre) mice were crossed with Kcnq2 -floxed ( fl/fl ) to...