A5088473729- Asymmetric Hydrogenation and Catalysis
- Cyclopropane Reaction Mechanisms
- Antibiotic Resistance in Bacteria
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Plant nutrient uptake and metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Legume Nitrogen Fixing Symbiosis
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Pharmaceutical and Antibiotic Environmental Impacts
- Catalysis for Biomass Conversion
- Coastal wetland ecosystem dynamics
- Tuberculosis Research and Epidemiology
- Enzyme Catalysis and Immobilization
- Catalytic Alkyne Reactions
California Institute of Technology
2023
Baylor College of Medicine
2020-2021
Virginia Tech
2017
In nature and synthetic chemistry, stereoselective [2 + 1] cyclopropanation is the most prevalent strategy for synthesis of chiral cyclopropanes, a class key pharmacophores in pharmaceuticals bioactive natural products. One extensively studied reactions organic chemist's arsenal, cyclopropanation, largely relies on use stereodefined olefins, which can require elaborate laboratory or tedious separation to ensure high stereoselectivity. Here, we report engineered hemoproteins derived from...
Bacterial resistance to β-lactam antibiotics is largely mediated by β-lactamases, which catalyze the hydrolysis of these drugs and continue emerge in response antibiotic use. β-Lactamases that hydrolyze last resort carbapenem class (carbapenemases) are a growing global health threat. Inhibitors have been developed prevent β-lactamase-mediated restore efficacy antibiotics. However, there few inhibitors available for problematic carbapenemases such as oxacillinase-48 (OXA-48). A DNA-encoded...
The legume symbiont Sinorhizobium meliloti is chemoattracted to compounds exuded by germinating seeds of its host alfalfa. This response mainly mediated the S. chemoreceptor McpU. McpU also has a prominent contribution in sensing synthetic amino acid (aa) mixture mimicking amounts and composition observed seed exudate. Here, we used hydrogel capillary assay quantify chemotactic responses individual aa alfalfa define role this behavior. exhibited positive chemotaxis all proteinogenic aa,...
Despite the advances in β-lactamase inhibitor development, limited options exist for class D carbapenemase known as OXA-48. OXA-48 is one of most prevalent carbapenemases carbapenem-resistant Enterobacteriaceae infections and not susceptible to available inhibitors. Here, we screened various low-molecular-weight compounds (fragments) against identify functional scaffolds development. Several biphenyl-, naphthalene-, fluorene-, anthraquinone-, azobenzene-based were found inhibit with low...
Abstract In nature and synthetic chemistry, stereoselective [2+1] cyclopropanation is the most prevalent strategy for synthesis of chiral cyclopropanes, a class key pharmacophores in pharmaceuticals bioactive natural products. One extensively studied reactions organic chemist’s arsenal, cyclopropanation, largely relies on use stereodefined olefins, which require elaborate laboratory or tedious separation to ensure high stereoselectivity. Here we report engineered hemoproteins derived from...