Nanodiamonds (NDs), as a new member of the carbon nanoparticles family, have attracted more and attention in biomedicine recently due to their excellent physical chemical properties. This paper summarizes main results from vitro vivo safety assessments NDs reports application development drug delivery systems. In view NDs' characteristics easy formation porous cluster structure solution, an adsorption model for variety functional molecules on ND clusters is proposed, which provides ideas...

It is still challenging to develop high-efficiency and low-cost non-noble metal-based electrocatalysts for hydrogen evolution reaction (HER) in pH-universal electrolytes. Herein, hierarchically porous W-doped CoP nanoflake arrays on carbon cloth (W-CoP NAs/CC) are synthesized via facile liquid-phase reactions a subsequent phosphorization process. The W-CoP NAs/CC hybrid can be directly employed as binder-free electrocatalyst delivers superior HER performance Especially, it very low...

Abstract The pathological lesions induced by multiwalled carbon nanotubes (MWCNTs) in bronchi and alveoli of mice were studied intratracheal instillation inhalation. In groups, the dose was 0.05 mg MWCNTs/mouse. Similar size clumps MWCNTs distributed alveoli. led to inflammation lining wall severe destruction alveolar netted structure around them. inhalation exposed aerosolized with mean concentration 32.61 mg/m 3 , intralung deposition roughly 0.07, 0.14, 0.21 8‐day group, 16‐day 24‐day...

Because of the sluggish oxygen evolution kinetics, it is extremely important but still challenging to develop low-cost, efficient, and stable electrocatalysts for reaction (OER) enhance efficiency water electrolysis. Herein, first time, we present a novel heterostructure catalyst, constructed by ultrafine NiS/Fe3O4 heterostructural nanoparticles decorated on carbon nanotube (CNT) matrix (NiS/Fe3O4 HNPs@CNT), which synthesized facile hydrothermal subsequent sulfurization process. The HNPs@CNT...

The interaction of multi-walled carbon nanotubes (MWNTs) with living unicellular protozoan Stylonychia mytilus was studied. results indicated that MWNTs were ingested largely by mytilus. Distribution in the cells, redistribution during dividing process and excretion from cells observed successfully optical microscope. dependence viability determined on concentration MWNTs, ranging 0.1 microg/ml to 200 microg/ml. It found exposure higher than 1.0 induced a dose-dependent growth inhibition...

This study examined the influence of multi-walled carbon nanotubes (MWNTs) on growth unicellular protozoan Tetrahymena pyriformis. Contrary to findings from most other investigations, our experiment indicated that MWNTs stimulated cells cultured in proteose peptone yeast extract medium (PPY). Atomic force microscopy images and thermogravimetric analysis showed spontaneous formation peptone–MWNT conjugates by noncovalent binding. Uptake large amounts pyriformis was responsible for...

This work reported the systematic influence of titanium dioxide nanoparticles (TiO2 NPs) with a diameter 3 nm on mice. Mice were repeated intratracheally instilled TiO2 NPs, once per-week for 4 consecutive weeks, at total dose 13.2 mg/kg. At 28 days post-instillation, biochemical parameters in broncboalveolar lavage fluid (BALF) and brain homogenate as well histopathologic changes tissues examined to describe subacute toxicity NPs. The results showed that NPs could induce lung damage, change...

Developing low-cost and high-efficiency electrocatalysts toward hydrogen evolution reaction (HER) in a wide pH range is still challenging. Herein, three-dimensional (3D) porous nanoarchitecture, constructed by vertical V-doped CoP nanowall arrays (V-CPNA), has been grown on carbon cloth (CC) via simple liquid-reaction approach subsequent phosphorization. As binder-free electrocatalyst, the V-CPNA/CC exhibits outstanding HER activity entire range. Particularly, it shows ultralow...

Nanodiamonds (NDs) possess many excellent physical and chemical properties that make them attractive materials for applications in biomedicine. In this paper, the adsorption delivery of a large amount sodium ions into cell interior by NDs serum-free medium is demonstrated. The excess inside cells induce osmotic stresses followed swelling an increase intracellular levels calcium reactive oxygen species (ROS), which leads to severe cellular damage. complete culture medium, however, serum...

Nanomaterials hold great promise for applications in the delivery of various molecules with poor cell penetration, yet its potential metal ions is rarely considered. Particularly, there limited insight about cytotoxicity triggered by nanoparticle-ion interactions. Oxidative stress one major toxicological mechanisms nanomaterials, and we propose that it may also contribute to complexes induced cytotoxicity. To explore nanodiamonds (NDs) as vehicles ion delivery, used a broad range...

Distinct platinum (Pt) nanozymes as peroxidase mimics have received extensive interest owing to their outstanding catalytic activity, high environmental tolerance, lower consumption, and great potential in replacing natural enzymes. However, easy agglomeration of Pt nanoparticles (Pt NPs) resulting from the surface free energy significantly decrease peroxidase-like activity. Herein, spherical polyelectrolyte brush (SPB)-stabilized ultrasmall NPs (SPB@Pt were prepared by a novel synthetic...

By varying the halide type and its addition rate, divergent synthesis of dibromo 1-pyrrolines, 3-azabicyclo[3.1.0]hex-2-enes, α, α-dibromo imines from N-allyl enamine was successfully achieved. 1-Pyrrolines 3-azabicyclo[3.1.0]hex-2-enes are...

Multi-walled carbon nanotubes (MWNTs) irradiated with gamma-rays were subjected to chemical modification thionyl chloride and decylamine. Products from treatment characterized by both FTIR Raman spectra. Element analysis (EA) thermogravimetric (TGA) for the modified soluble MWNTs (s-MWNTs) indicated that gamma-radiation increased concentration of functional groups bound MWNTs, which arose due increasing number defect sites created on gamma-photons. Compared untreated gamma-irradiation...

Asymmetric line shape in a spectral profile, quantified by the Fano parameter q, is hallmark feature of resonances. In photonics, this asymmetry captures physics coupling localized resonances to radiative continuum and nourishes many photonic devices. Recent advances have suggested full control q from negative infinity positive infinity; here we realize negative-to-positive transition an active successive manner using Ge2Sb2Te5 (GST)-based resonator Mid-infrared. The structure consists two...

Abstract Zinc finger proteins (ZNF) play important roles in various physiological processes. Here we report that ZNF300, a novel zinc protein, identified specifically humans, promotes tumour development by modulating the NF‐κB pathway. Inflammatory factors were found to induce ZNF300 expression HeLa cell line, and further enhanced signalling activating TRAF2 physically interacting with IKKβ. Furthermore, overexpression increased ERK1/2 phosphorylation of c‐myc, IL‐6, IL‐8 but decreased p21...

Understanding the internalization of nanoparticles in cells is great interest for diagnostic and therapeutic applications. We investigated cellular uptake distribution TiO2 by high lateral resolution transmission electron microscopy (TEM) X-ray microscopy. TEM results showed that nanoparticle mostly occurred via endocytosis were distributed cytoplasm. 3D reconstructed tomography also confirmed aggregates mainly over cell membrane surface.