A5101432744- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Advanced Algorithms and Applications
- Seismic Imaging and Inversion Techniques
- NMR spectroscopy and applications
- Melanoma and MAPK Pathways
- Metaheuristic Optimization Algorithms Research
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Lipid Membrane Structure and Behavior
- Geology and Paleoclimatology Research
- Hydrocarbon exploration and reservoir analysis
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Sensor and Control Systems
- Neurological Disease Mechanisms and Treatments
- Geological and Geochemical Analysis
- Geophysical and Geoelectrical Methods
- Machine Fault Diagnosis Techniques
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Huazhong University of Science and Technology
2014-2025
Xuzhou Medical College
2010-2024
Nanxi Mountain Hospital
2024
Shanghai Sixth People's Hospital
2024
Shanghai University of Sport
2024
China Geological Survey
2021-2024
Shandong First Medical University
2018-2023
Shandong Tumor Hospital
2018-2023
Dalian Medical University
2023
Second Affiliated Hospital of Dalian Medical University
2022-2023
The complex pathogenesis of osteoporosis includes excessive bone resorption, insufficient formation and inadequate vascularization, a combination which is difficult to completely address with conventional therapies. Engineered exosomes carrying curative molecules show promise as alternative therapies, but depend on specifically-functionalized vesicles appropriate engineering strategies. Here, we developed an exosome delivery system based secreted by mesenchymal stem cells (MSCs) derived from...
Exploring a rational delivery system of integrating chemotherapy with immunotherapy to broaden benefits cancer immunochemotherapy is still under challenge. Herein, we developed doxorubicin (DOX)-loaded biomimetic hybrid nanovesicles (DOX@LINV) via fusing artificial liposomes (LIPs) tumor-derived (TNVs) for combinational immunochemotherapy. DOX@LINV homologous targeting ability could deliver DOX tumor tissue and elicit an effective immunogenic cell death response improve the immunogenicity...
Blocking immune checkpoints with monoclonal antibody has been verified to achieve potential clinical successes for cancer immunotherapy. However, its application impeded by the "cold" tumor microenvironment. Here, weak acidity-responsive nanoparticles co-loaded CRISPR/Cas9 and paclitaxel (PTX) ability convert into "hot" are reported. The exhibited high cargo packaging capacity, superior transfection efficiency, well biocompatibility, effective accumulation. encapsulated in could specifically...
Surface charge plays a fundamental role in determining the fate of nanoparticle, and any encapsulated contents, vivo. Herein, we describe, visualise real time, light-triggered switching liposome surface charge, from neutral to cationic, situ vivo (embryonic zebrafish). Prior light activation, intravenously administered liposomes, composed just two lipid reagents, freely circulate successfully evade innate immune cells present fish. Upon irradiation switching, however, liposomes rapidly...
The common and frequent disease, ulcerative colitis (UC), causes serious physical mental distress to patients. M2 macrophages have proven play a role in anti-inflammation, which is new potential target for UC therapy. In this study, we designed safe macrophages-targeting oral drug delivery system. Natural products, berberine (BBR), Epigallocatechin Gallate (EGCG) with anti-inflammatory activity were assembled encapsulated into yeast microcapsule (YM), generating therapeutic system...
Abstract Insufficient bone formation and excessive resorption caused by estrogen deficiency are the major factors resulting in incidence of postmenopausal osteoporosis (PMOP). The existing drugs usually fail to re‐establish osteoblast/osteoclast balance from both sides generate side‐effects owing lack bone‐targeting ability. Here, engineered cell‐membrane‐coated nanogels PNG@mR&C capable scavenging receptor activator nuclear factor‐κB ligand (RANKL) responsively releasing therapeutic PTH...
Acute Respiratory Distress Syndrome (ARDS) is a clinically severe respiratory disease that causes medical and economic burden. To improve therapeutic efficacy, effectively targeting delivery to the inflamed lungs cells remains an ongoing challenge. Herein, we designed engineered biomimetic nanovesicles (DHA@ANeu-DDAB) by fusion of lung-targeting functional lipid, neutrophil membrane containing activated β2 integrins, docosahexaenoic acid (DHA). By advantage lung lipid integrin adhesion,...
Abstract Although cisplatin‐based neoadjuvant chemotherapy is an efficient therapy approach for triple‐negative breast cancer (TNBC), it has dismal prognosis and modestly improved survival benefit. Here, a synergistic immunotherapy of TNBC premised on the elicitation promotion immunogenic cell death (ICD) response, through transformable nanoparticle‐enabled contemporaneous delivery cisplatin, adjudin, WKYMVm reported. The nanoparticles can sequentially respond to matrix metalloproteinases‐2,...
Abstract Membrane fusion results in the transport and mixing of (bio)molecules across otherwise impermeable barriers. In this communication, we describe temporal control targeted liposome–liposome membrane contents using light as an external trigger. Our method relies on steric shielding rapid, photoinduced deshielding complementary fusogenic peptides tethered to opposing liposomal membranes. analogous approach, were also able demonstrate precise spatiotemporal liposome accumulation at...
The zwitterionic Streptococcus pneumoniae serotype 1 polysaccharide (Sp1) is an important anchor point for our immune system to act against streptococcal infections. Antibodies can recognize Sp1 saccharides, and it has been postulated that elicit a T-cell-dependent reaction as be presented by MHC-II molecules. To unravel the molecular mode of action this unique we here describe chemical synthesis set fragments, ranging from 3 12 monosaccharides in length. We outline synthetic approach...
The biosynthesis of nanomedicine has gained enormous attention and exhibited promising prospects, while the underlying mechanism advantage remain not fully understood. Here, a cell-reactor based on tumor cells is developed to obtain biogenetic gold nanoparticles (Au@MC38) for sensitizing radiotherapy boosting immune responses. It demonstrates that intracellular biomineralization exocytosis process Au@MC38 can be regulated by cellular metabolites level other factors, such as glutathione...
Improving tumor immunogenicity is critical for increasing the responsiveness of triple-negative breast cancer (TNBC) to anti-PD-(L)1 treatment. Here, we verified that chidamide (CHI), an epigenetic modulator, could elicit immunogenic cell death within TNBC enhance and antitumor immune response. Additionally, CHI increased expression level PD-L1, MHC I, II on cells, which contributed T-cell recognition PD-1/PD-L1 blockade therapy The synergistic efficacy PD-L1 was further explored through...
Delayed diabetic wound healing has placed an enormous burden on society. The key factors limiting include unresolved inflammation and impaired angiogenesis. Platelet-rich plasma (PRP) gel, a popular biomaterial in the field of regeneration, limited applications due to its non-injectable properties rapid release degradation growth factors. Here, we prepared injectable hydrogel (DPLG) based PRP laponite by simple one-step mixing method. Taking advantages non-covalent interactions, DPLG could...
In recent years, microbiota-based tumor immunotherapy has become a hotspot in cancer research. However, the use of microorganisms alone to activate immune response for antitumor therapy was unsatisfactory. this study, we biosynthesized gold nanoparticles (AuNPs) and platinum (PtNPs) based on yeast microcapsules treatment synergy with chemodynamic (CDT) photothermal (PTT). We generated AuNPs PtNPs (YAP) fabricated nanoscale particles (Bre-YAP) by ultrasonic fragmentation differential...
In this study, we report on a new approach for remote temperature probing that provides accuracy as good 0.017°C (0.0055% accuracy) by measuring the magnetisation curve of magnetic nanoparticles. We included here theoretical model construction and inverse calculation method explored impact caused dependence saturation applied field range. The reported results are great significance in establishment safer protocols hyperthermia therapy thermal assisted drug delivery technology. Likewise, our...
In the treatment of malignant tumors, combination chemotherapy that can directly kill tumor cells and immunotherapy activate body's immune system regulate microenvironments is becoming one most promising cancer treatments. However, to co-deliver agents with different physicochemical properties for immunochemotherapy still facing a challenge. Here, nanoparticles are developed co-delivery hydrophobic chemotherapeutic drug paclitaxel (PTX) biomacromolecule interleukin-12 (IL-12) through...
In the development of chemo-immunotherapy, many efforts have been focusing on designing suitable carriers to realize co-delivery chemotherapeutic and immunotherapeutic with different physicochemical properties mechanisms action. Besides, rapid drug release at tumor site minimal degradation is also essential facilitate antitumor effect in a short time. Here, we reported cancer cell membrane-coated pH-responsive nanogel (NG@M) co-deliver paclitaxel (PTX) agent interleukin-2 (IL-2) under mild...
Acute respiratory distress syndrome (ARDS) has been a life threat for patients in ICUs. Vast efforts have devoted, while no medication proved viable, which may be ascribed to inadequate drug delivery damaged tissues and insufficient control of lung inflammation. Given the anti-inflammatory role M2-type macrophages, M2 macrophage-derived nanovesicles lung-targeting liposomes are cofused fabricate hybrid liposomes–nanovesicles (LNVs). Benefiting from incorporated lung-homing moiety, LNVs...
Pyroptosis, a highly inflammatory form of programmed cell death, has emerged as promising target for cancer immunotherapy. However, in the context pyroptosis execution, while both caspase-3 and GSDME are essential, it is noteworthy that frequently under-expressed cold tumors. To overcome this limitation, engineered cellular nanovesicles (NVs) presenting TRAIL on their membranes (NV