A5045704413- Probabilistic and Robust Engineering Design
- Vibration Control and Rheological Fluids
- Mechanical Engineering and Vibrations Research
- Vehicle Dynamics and Control Systems
- Hydraulic and Pneumatic Systems
- Vibration and Dynamic Analysis
- Structural Health Monitoring Techniques
- Acoustic Wave Phenomena Research
- Dynamics and Control of Mechanical Systems
- Solar and Space Plasma Dynamics
- Vehicle Noise and Vibration Control
- Control Systems and Identification
- Innovative Energy Harvesting Technologies
- Effects of Vibration on Health
- Solar Radiation and Photovoltaics
- Gear and Bearing Dynamics Analysis
- Elasticity and Material Modeling
- Gut microbiota and health
- Signaling Pathways in Disease
- Advanced Drug Delivery Systems
- Nonlinear Dynamics and Pattern Formation
- Wind and Air Flow Studies
- Maritime Navigation and Safety
- Biochemical and Structural Characterization
- Image Processing Techniques and Applications
Huazhong University of Science and Technology
2014-2024
Wuhan Ship Development & Design Institute
2021-2023
Union Hospital
2022
Wuhan Children's Hospital
2022
Chinese Academy of Meteorological Sciences
2011
Chinese Academy of Sciences
2011
National Space Science Center
2011
The common and frequent disease, ulcerative colitis (UC), causes serious physical mental distress to patients. M2 macrophages have proven play a role in anti-inflammation, which is new potential target for UC therapy. In this study, we designed safe macrophages-targeting oral drug delivery system. Natural products, berberine (BBR), Epigallocatechin Gallate (EGCG) with anti-inflammatory activity were assembled encapsulated into yeast microcapsule (YM), generating therapeutic system...
Conventional chemotherapy has poor efficacy in triple-negative breast cancer (TNBC) which is highly heterogeneous and aggressive. Imaging-guided therapy usually combined with diverse treatment modalities, could realize the integration of diagnosis treatments. Therefore, primary challenge for combinational designing proper delivery systems to accomplish multiple synergistic effects.Herein, a facile nanoplatform was manufactured fulfill all-in-one approaches TNBC therapy. Fe3+-based...
Immunogenic dying tumor cells hold promising prospects as cancer vaccines to activate systemic immunity against both primary and metastatic tumors. Especially, X-ray- induced are rich in highly immunogenic tumor-associated antigens self-generated dsDNA potent adjuvants. However, we found that the X-ray induction process can result excessive exposure of phosphatidylserine vaccines, which specifically bind with MerTK receptor on macrophages, acting a "checkpoint" facilitate immune silence...
It is challenging to perform path planning tasks in complex marine environments as the unmanned surface vessel approaches goal while avoiding obstacles. However, conflict between two subtarget of obstacle avoidance and approaching makes difficult. Thus, a method for based on multiobjective reinforcement learning proposed under environment with high randomness multiple dynamic Firstly, scene set main scene, scenes including are divided from it. The action selection strategy each trained...
High-dimensional high-frequency continuous-vibration control problems often have very complex dynamic behaviors. It is difficult for the conventional methods to obtain appropriate laws from such systems suppress vibration. This paper proposes a new vibration controller by using reinforcement learning (RL) and finite-impulse-response (FIR) filter. First, simulator with enough physical fidelity was built system. Then, deep deterministic policy gradient (DDPG) algorithm interacted find...
The present study focuses on the kinematic analysis of a PPPR spatial serial mechanism with large number geometric errors. is implemented in three steps: (1) development map between end-effector position error and source errors within chains using homogeneous transformation matrix; (2) selection which have significant effects positioning accuracy by sensitivity analysis; (3) are modelled as interval variables. computational algorithms presented for workspace consideration results show that...
<div class="section abstract"><div class="htmlview paragraph">The structure of a classic self-energizing synchronizer is presented, and simulation model developed for analyzing the performance. The has disk spring several energizing teeth on sleeve increasing shift force. Besides, asymmetric arrangement chamfer applied to increase torque rotating ring gears smoothly. parameterized typical with ADAMS studying In order truly reflect reality, claw plate are connected gear through bushing force...
A multibody dynamic model of the self-energizing synchronizer in a 14-speed manual transmission gearbox is presented. While contact forces between engaged splines/teeth and friction torques synchro rings are hardly observed by conventional experiments, detailed models consideration lubrication established to simulate these contact/friction during shifting. The space motion sleeve considered; thus, differences teeth can be simulated observed. pneumatic varying shift force acting on...
<div class="section abstract"><div class="htmlview paragraph">Practical vehicle contains many uncertainties which may result from poorly known or variable parameters uncertain inputs. These can be presented by fuzzy parameters, random interval parameters. A new analysis method is applied to the case in system both and This a systematic integration of Polynomial Chaos (PC) theory accounts for uncertainty Chebyshev inclusion function uncertainty. multi-body model with used as numerical...