A5103251321- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Retinoids in leukemia and cellular processes
- Privacy-Preserving Technologies in Data
- Cryptography and Data Security
- Composite Structure Analysis and Optimization
- Industrial Technology and Control Systems
- Immunotherapy and Immune Responses
- Anesthesia and Pain Management
- Probabilistic and Robust Engineering Design
- Lattice Boltzmann Simulation Studies
- Vehicle emissions and performance
- T-cell and B-cell Immunology
- Nonlinear Dynamics and Pattern Formation
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced Sensor and Control Systems
- Advanced Algorithms and Applications
- Materials Engineering and Processing
- Tribology and Lubrication Engineering
- Pancreatic and Hepatic Oncology Research
- Corrosion Behavior and Inhibition
- Gear and Bearing Dynamics Analysis
- Lung Cancer Treatments and Mutations
- Manufacturing Process and Optimization
Huazhong University of Science and Technology
2014-2024
Union Hospital
2011-2024
Tongji Hospital
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2022
Institute of Hematology & Blood Diseases Hospital
2013-2022
Soochow University
2019-2021
First Affiliated Hospital of Soochow University
2019-2021
West China Second University Hospital of Sichuan University
2021
Sichuan University
2021
Massachusetts General Hospital
2020
Gradient descent is a widely used paradigm for solving many optimization problems. Stochastic gradient performs series of iterations to minimize target function in order reach local minimum. In machine learning or data mining, this corresponds decision model that be discovered. The underlies commonly techniques mining and learning, such as neural networks, Bayesian genetic algorithms, simulated annealing. To the best our knowledge, there has not been any work extends notion privacy...
Gradient descent is a widely used paradigm for solving many optimization problems. aims to minimize target function in order reach local minimum. In machine learning or data mining, this corresponds decision model that be discovered. paper, we propose preliminary formulation of gradient with privacy preservation. We present two approaches-stochastic approach and least square approach-under different assumptions. Four protocols are proposed the approaches incorporating various secure building...
In large-scale structured scenes, efficient and reliable global localization is hard to achieve for mobile robots due the substantial increase in search space. This article addresses this issue by proposing an optimized branch bound (BnB) based using multiscale/resolution maps, which can efficiently find optimal initial pose with a high success rate. Multiscale feature maps (MSFMs) are first constructed reflect explicit point/line information of scene. Then, narrow position space, robust...
Acute promyelocytic leukemia (APL) is mostly due to the chromosome translocation t (15; 17) (q22; q12), leading formation of PML-RARA fusion protein. Some patients carried rare involving RARA gene, who were called variant APL caused by RAR family (RARA, RARB, and RARG) partner genes. STAT5b-RARA was a type molecular genetic abnormality with unfavorable prognosis which have been reported in only 18 cases APL. Knowledge (+) treatment still limited.We presented 38-year-old female case, positive...
ORIENT-16, a phase III clinical trial conducted at 62 hospitals in China, reported that add-on sintilimab (Sin) to chemotherapy (Chemo) had favorable efficacy (
Background Resembling acute promyelocytic leukemia (APL) is a unique subtype of APL who sharing clinical, morphological, and immunophenotypic features with typical APL, but lacking evidence PML-RARA fusion gene usually insensitive to arsenic trioxide (ATO) all-trans retinoic acid (ATRA). For years, RARA, RARB RARG rearrangement were found in resembling continually. The confirmed partner genes included CPSF6, NUP98, NPM1, PML, HNRNPC. These patients group rare molecular genetic abnormality...
Purpose Metamodels are widely used to replace simulation models in engineering design optimization reduce the computational cost. The purpose of this paper is develop a novel sequential sampling strategy (weighted accumulative error sampling, WAES) obtain accurate metamodels and apply it improve quality global optimization. Design/methodology/approach A single objective formulation constructed adaptively select new sample points. In formulation, point with maximum weighted predicted obtained...
All-trans retinoic acid (ATRA) induces clinical remission in most acute promyelocytic leukemia (APL) patients by inducing terminal differentiation of APL cells toward mature granulocytes. Here we report that human umbilical cord-derived mesenchymal stem (UC-MSCs) are capable granulocytic the APL-derived NB4 cell line as well primary and also cooperate with ATRA an additive manner. Transwell coculture experiments revealed UC-MSCs' differentiation-inducing effect was mediated through some...
Chronic graft-versus-host disease (cGVHD) remains a major complication during the late phase of allogeneic hematopoietic stem cell transplantation (allo-HSCT). IL-39, newly described pro-inflammatory cytokine belonging to IL-12 family, plays role in lupus development. Recently, IL-39 has been identified as pathogenic factor acute GVHD (aGVHD). However, pathogenesis cGVHD unclear. We constructed recombinant plasmid and established scleroderma lupus-like models. Quantitative PCR enzyme-linked...
In recent years, the sandwich bridge decks with GFRP face sheets and light weight material core have been widely used in world due to their advantages of low cost, high strength ratios, corrosion resisting. However, as decks, most them are foot bridges rather than highway because ultimate bending initial stiffness relatively low. To address this issue expand scope use, a simple innovative deck foam-web core, manufactured by vacuum assisted resin infusion process, is developed. An...
Objective The effectiveness of sugemalimab vs. placebo in post-chemoradiotherapy patients with locally advanced, unresectable stage III NSCLC has been demonstrated and approved by China National Medical Products Administration. purpose this study was to assess the cost-effectiveness for consolidation treatment from perspective Chinese healthcare system. Methods A 3-state Markov model a 3-week cycle length performed appraise incremental cost-utility ratio (ICUR) therapy based on GEMSTONE-301...
IL-Y, a synthetic member of IL-12 cytokine family, was found to exert potent immunosuppressive effects by inhibiting the differentiation and activation Th1 Th17 cells. However, role IL-Y in development chronic graft- versus -host disease (cGVHD) remains unknown. Here, using murine models scleroderma-like lupus-like cGVHD, we examined function pathogenesis cGVHD hydrodynamically injecting minicircle-IL-Y expressing plasmids (MC IL-Y). In contrast with reported immune suppressive...
An accurate simulation model of the lubrication system is essential for early design heavy truck transmission. In this article, a detailed computational method flow network analysis circuit developed based on hydraulic theory, and resistance through oil pipes orifices also taken into consideration. Then, Next Limit Technologies’ XFlow, potential new three-dimensional fluid dynamics software lattice Boltzmann method, adopted to obtain relationship between delivery effect in low-pressure...
A polymer drilling fluid containing high content of hydrogen sulfide was used as the corrosive medium to investigate effects temperature, flow velocity, pH value and partial pressure ratio CO 2 / H S on corrosion behavior strength drill pipe steel S135 G105. The morphology composition products were analyzed well. It found that average rate two types increased with increasing temperature medium, decrease slightly within 60°C-80°C keep almost unchanged above 120°C. At same time, steels had...
Due to great variety additives and disposal difficulty, chemical method, biochemical method solidification are adopted treat fracturing wastewater in oil field. These processes easily bring about shortcomings, including high cost secondary pollution. Studied on the treatment of 4# well Sichuan Oilfield by modified bentonite loading TiO2-Ag2O composite catalyst, COD removal rate is determined for different condition pH value solution, adding content TiO2, inflating volume light application...
Introduction: The major complication of Obliterative Bronchiolitis (OB) is characterized by epithelial cell loss, fibrosis, and luminal occlusion the terminal small airways, which limits long-term survival recipient after lung transplantation. However, underlying mechanisms are still not fully clarified. This research aims to investigate whether iron overload-induced ferroptosis involved in OB development provide a new target for prevention. Materials Methods: Allograft orthotopic tracheal...