A5037744441- Ultrasound Imaging and Elastography
- Photoacoustic and Ultrasonic Imaging
- Malaria Research and Control
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Optical Coherence Tomography Applications
- Immunotherapy and Immune Responses
- Coronary Interventions and Diagnostics
- Mosquito-borne diseases and control
- Nanoplatforms for cancer theranostics
- Protease and Inhibitor Mechanisms
- Nanoparticle-Based Drug Delivery
- Retinoids in leukemia and cellular processes
- Cancer Immunotherapy and Biomarkers
- Atherosclerosis and Cardiovascular Diseases
- Ultrasound and Hyperthermia Applications
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Parasites and Host Interactions
- HIV/AIDS drug development and treatment
- Chemokine receptors and signaling
- Nanoparticles: synthesis and applications
- Photodynamic Therapy Research Studies
- Cancer, Hypoxia, and Metabolism
Harry Perkins Institute of Medical Research
2016-2025
Queen Elizabeth II Medical Centre
2016-2025
The University of Western Australia
2015-2025
Curtin University
2021-2025
Target (United States)
2020
University of California, Santa Barbara
2012-2016
University of California System
2012
Institut thématique Génétique, génomique et bioinformatique
2012
Sanford Burnham Prebys Medical Discovery Institute
2011-2012
Cancer Research Center
2011
Solid tumors are intrinsically resistant to immune rejection. Abnormal tumor vasculature can act as a barrier for cell migration into tumors. We tested whether targeting IFNγ and/or TNFα pancreatic neuroendocrine alleviate suppression. found that intratumoral causes rapid vessel loss, which does not support anti-tumor immunity. In contrast, low-dose enhances T-cell infiltration and overall survival, an effect is exclusively mediated by CD8 + effector cells. Intriguingly, lymphocyte influx...
Abstract High‐grade brain cancer such as glioblastoma (GBM) remains an incurable disease. A common feature of GBM is the angiogenic vasculature, which can be targeted with selected peptides for payload delivery. We assessed ability micelle‐tagged, vascular homing RGR, CGKRK and NGR to specifically bind blood vessels in syngeneic orthotopic models. By using peptide deliver tumour necrosis factor (TNF) superfamily member LIGHT (also known TNF 14; TNFSF14) vessels, we have generated a reagent...
Due to limited current therapies, metastases are the primary cause of mortality in cancer patients. Here, we employ a fusion compound cytokine LIGHT and vascular targeting peptide (LIGHT-VTP) that homes angiogenic blood vessels tumors. We show mouse lung normalization tumor vasculature by LIGHT-VTP prevents cell intravasation. Further, efficiently targets pathological pre-metastatic niche, reducing hyper-permeability extracellular matrix (ECM) deposition, thus blocking metastatic...
The ability to selectively deliver compounds into atherosclerotic plaques would greatly benefit the detection and treatment of disease. We describe such a delivery system based on 9-amino acid cyclic peptide, LyP-1. LyP-1 was originally identified as tumor-homing peptide that specifically recognizes tumor cells, lymphatics, tumor-associated macrophages. As receptor for LyP-1, p32, is expressed in plaques, we tested home plaques. Fluorescein-labeled intravenously injected apolipoprotein E...
The ability to detect and quantify macrophage accumulation can provide important diagnostic prognostic information for atherosclerotic plaque. We have previously shown that LyP-1, a cyclic 9-amino acid peptide, binds p32 proteins on activated macrophages, facilitating the visualization of plaque with PET. Yet, in vivo monomeric [(18)F]FBA-LyP-1 was low (0.31 ± 0.05%ID/g). To increase avidity LyP-1 constructs p32, we synthesized dendritic form solid phase using lysine as core structural...
Highlights•LIGHT targeting into tumors normalizes the vasculature and improves therapy•Vascular integrity is restored by inducing pericyte contractility•LIGHT triggers a peri-vascular signaling cascade involving macrophages TGF-β•LIGHT-RGR effects are Rho kinase-dependent restricted to vascular bedSummaryNormalization of tumor an emerging concept shown improve anti-cancer therapy. However, there currently no clinical interventions that effect long-lasting normalization. Here, we have...
The vasa vasorum (VV) have gathered considerable interest over the last decade due to its role in vascular wall biology and pathology; however, while coronary VV are relatively well studied, anatomy of peripheral VV, such as those aorta, remains poorly described, hampering knowledge their diseases. Through careful retrieval porcine thoracic aorta successful microthrombi removal, was perfused with BriteVu™ followed by micro-computed tomography (micro-CT) scanning image obtain a 3D...
Current anticancer therapy is a delicate balance between elimination of malignant cells and harmful side effects for the host. In this study, we used tumor-homing peptide to engineer anti-CD40 agonist antibodies recombinant IL-2 such that they were selectively delivered into spontaneously arising tumors in transgenic mouse model islet cell carcinogenesis. Intravenous injection these agents, either separately or together, led accumulation vicinity tumor neovessels without toxic effects....
Accessibility of tumors for highly effective local treatment represents a major challenge anticancer therapy. Immunostimulatory oligodeoxynucleotides (ODN) with CpG motifs are ligands TLR9, which prime spontaneous antitumor immunity, but less when applied systemically. We therefore developed liposome-based agent selective delivery CpG-ODN into the tumor environment. A peptide that specifically targets angiogenic endothelial cells in transgenic model islet cell carcinogenesis was engrafted...
Drug treatment of severe malaria must be rapidly effective. Suppositories may valuable for childhood when circumstances prevent oral or parenteral therapy. We compared artesunate suppositories (n = 41; 8 to 16 mg/kg body weight at 0 and 12 h then daily) with intramuscular (i.m.) artemether 38; 3.2 1.6 in an open-label, randomized trial children Plasmodium falciparum Papua New Guinea (PNG). Parasite density temperature were measured every 6 > 72 h. Primary endpoints included times 50% 90%...
Article11 November 2019Open Access Source DataTransparent process Immune-mediated ECM depletion improves tumour perfusion and payload delivery Yen Ling Yeow Harry Perkins Institute of Medical Research, Centre for QEII Centre, The University Western Australia, Perth, WA, Australia Search more papers by this author Venkata Ramana Kotamraju Cancer Research Center, Sanford Burnham Prebys Discovery Institute, La Jolla, CA, USA Xiao Wang Meenu Chopra Nasibah Azme Jiansha Wu Tobias D Schoep...
Blood vessels inside tumors are crucial for cancer survival and progression but equally contribute to the tumor's intrinsic resistance therapy. Abnormal blood flow in local tumor environment acts as a physiological barrier delivery of chemotherapeutic agents. Furthermore, vasculature can also act immune cell migration into parenchyma. Much has been made anti-angiogenic therapies that specifically inhibit vessel growth. However, recent findings demonstrate chaotic architecture be reversed...
In this paper, we describe a technique capable of visualizing mechanical properties at the cellular scale deep in living tissue, by incorporating gradient-index (GRIN)-lens microendoscope into an ultrahigh-resolution optical coherence elastography system.The system, after endoscope, has lateral resolution 1.6 µm and axial 2.2 µm.Bessel beam illumination Gaussian mode detection are used to provide extended depth-of-field 80 µm, which is 4-fold improvement over fully case with same...
Background and aims Fatty streaks initiating the formation of atheromatous plaque appear in tunica intima. The media is not known to be a nidus for lipid accumulation atherogenesis. We assessed changes response micro-injury produced pig aorta. In addition, we human carotid endarterectomy plaques indication atheroma initiation media. Methods Three healthy landrace female pigs underwent laparotomy inject autologous blood create micro-hematomas at 6 sites within infrarenal abdominal These were...