A5022208867- Veterinary Pharmacology and Anesthesia
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Veterinary Equine Medical Research
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Pain Management
- Preterm Birth and Chorioamnionitis
- Organ Donation and Transplantation
- Human-Animal Interaction Studies
- Organ Transplantation Techniques and Outcomes
- Animal Behavior and Welfare Studies
- Renal and Vascular Pathologies
- Neuroscience of respiration and sleep
- Veterinary Orthopedics and Neurology
- Meat and Animal Product Quality
- Animal testing and alternatives
- Thermal Regulation in Medicine
- Anesthesia and Neurotoxicity Research
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacological Effects and Assays
- Hemodynamic Monitoring and Therapy
- Birth, Development, and Health
- Congenital Anomalies and Fetal Surgery
- Pain Mechanisms and Treatments
The University of Western Australia
2014-2024
Murdoch University
2011-2024
King Edward Memorial Hospital
2018
University of Glasgow
2005-2007
Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration strengths and weaknesses any model disease is fundamental effective meaningful translation preclinical research. Studies sheep have made significant contributions our understanding normal abnormal development fetus. As a pregnancy, enabled scientists clinicians answer questions about etiology treatment poor maternal,...
Ex-vivo uterine environment (EVE) therapy uses an artificial placenta to provide gas exchange and nutrient delivery a fetus submerged in amniotic fluid bath. Development of EVE may allow us treat very premature neonates without mechanical ventilation. Meanwhile, elevations fetal inflammation are associated with adverse neonatal outcomes. In the present study, we analysed survival, pulmonary maturation preterm lambs maintained on using parallelised umbilical circuit system low priming...
Modern veterinary medicine offers numerous options for treatment and clinicians must decide on the best one to use. Interventions causing short-term harm but ultimately benefitting animal are often justified as being in animal's interest. Highly invasive clinical procedures with high morbidity low success rates may not be A working party was set up by European College of Veterinary Anaesthesia Analgesia discuss ethics practice improve approach ethically challenging cases. Relevant literature...
Mechanical ventilation with normal tidal volumes (VT) causes lung and systemic inflammation in preterm sheep. is associated bronchopulmonary dysplasia (BPD) infants, the addition of budesonide to surfactant decreases BPD clinical trials. Budesonide will decrease injury from mechanical for 24 h Lambs at 126 ± 1 day gestational age were delivered randomized either: 1) (200 mg/kg) or 2) mixed (0.25 before VT 7-8 ml/kg 2, 6, (n = 6 7/group). Lung physiology levels plasma measured. tissue,...
Four groups of 20 dogs were anaesthetised by means target‐controlled infusions propofol designed to achieve 2·5 µg/ml, 3·0 3·5 µg/ml or 4·0 in blood. The dogs’ pulse rate and respiratory recorded before premedication induction, immediately after endotracheal intubation three five minutes later (times 0, 3 5, respectively), their arterial blood pressure was oscillometrically just induction at times 5. targets 2·5, 3·0, resulted the successful anaesthesia 13 (65 per cent), 16 (80 (100 cent)...
Mechanical ventilation causes lung injury and systemic inflammatory responses in preterm sheep is associated with bronchopulmonary dysplasia (BPD) infants. Budesonide added to surfactant decreased BPD by 20% We wanted determine the effects of budesonide on from high tidal volume (VT) lambs. Ewes at 125 ± 1 days gestational age had fetal surgery expose head chest placental circulation intact. Lambs were randomized 1) mechanical escalating VT target 15 ml/kg min or 2) continuous positive...
Intra-abdominal hypertension is common in critically ill patients and associated with increased morbidity mortality. The optimal ventilation strategy remains unclear these patients. We examined the effect of positive end-expiratory pressures (PEEP) on functional residual capacity (FRC) oxygen delivery a pig model intra-abdominal hypertension. Thirteen adult pigs received standardised anaesthesia ventilation. randomised three levels pressure (3 mmHg (baseline), 18 mmHg, 26 mmHg) four commonly...
Abstract Ex vivo uterine environment (EVE) therapy is an experimental neonatal intensive care strategy wherein gas exchange performed by membranous oxygenators attached to the umbilical vessels. Our aim was assess ability of a newly refined EVE system maintain key physiological parameters in preterm lambs within optimal ranges for 48 h. group; n = 6: Preterm were delivered under general anesthesia at 115 ± 2 days gestational age. Animals submerged bath artificial amniotic fluid on...
Mechanical ventilation from birth with normal tidal volumes (V
This study looked at the use and efficacy of alfaxalone for total intravenous anaesthesia (TIVA) in cats. Following intramuscular medetomidine (20 μg/kg) morphine (0.3 mg/kg) premedication, was induced maintained with alfaxalone. Patients were breathing 100% oxygen. Heart rate (HR), respiratory (RR), end-tidal carbon dioxide, oxygen saturation haemoglobin indirect arterial blood pressure via Doppler (DAP) recorded every 5 mins. Thirty-four cats (10 males 24 females), between age 6 18 months,...
The applicability of electrical impedance tomography (EIT) in birds is unknown. This study aimed to evaluate the use EIT anaesthetised chickens four recumbency positions. Four adult Hyline were with isoflurane oxygen, and intubated endotracheally for computed (CT). A rubber belt was placed around coelom caudal shoulder joint. chicken-specific finite element (FE) model, which essential generate anatomically accurate functional images analysis, constructed based on CT obtained at level. Ten...
Chorioamnionitis is a common antecedent of preterm birth and induces inflammation oxidative stress in the fetal lungs. Reducing lungs may improve respiratory outcomes infants. Creatine an organic acid with known anti-inflammatory antioxidant properties. The objective study was to evaluate efficacy direct creatine supplementation reduce arising from utero proinflammatory stimulus. Fetal lambs (
Histologic chorioamnionitis, frequently associated with preterm births and adverse outcomes, results in prolonged exposure of fetuses to infectious agents pro-inflammatory mediators, such as LPS. Endotoxin tolerance-type effects were demonstrated fetal sheep following repetitive systemic or intra-amniotic (i.a.) exposures LPS, suggesting that i.a. LPS would cause endotoxin tolerance a postnatal dose sheep. In this study, randomized pregnant ewes received either two injections saline prior...
Background and aims Fatty streaks initiating the formation of atheromatous plaque appear in tunica intima. The media is not known to be a nidus for lipid accumulation atherogenesis. We assessed changes response micro-injury produced pig aorta. In addition, we human carotid endarterectomy plaques indication atheroma initiation media. Methods Three healthy landrace female pigs underwent laparotomy inject autologous blood create micro-hematomas at 6 sites within infrarenal abdominal These were...
The extent of placental transfer medetomidine and ketamine is unknown in pregnant ewes. Date-mated singleton ( n = 8) twin merino cross ewes were anaesthetized for Caesarean delivery preterm lamb fetuses. A combination (20 μg/kg) (10 mg/kg) was administered by intravenous injection surgery performed immediately thereafter. Blood samples collected from the ewe at one, five 10 min after umbilical vein fetus delivery. Non-pregnant also 8). There no difference plasma concentration or when...