A5103280492- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- Diet, Metabolism, and Disease
- Neonatal Respiratory Health Research
- Growth Hormone and Insulin-like Growth Factors
- Preterm Birth and Chorioamnionitis
- Infant Development and Preterm Care
- Aldose Reductase and Taurine
- Diet and metabolism studies
- Infant Nutrition and Health
- Neonatal and fetal brain pathology
- Obesity, Physical Activity, Diet
- Neuroscience of respiration and sleep
- Health, Environment, Cognitive Aging
- Neuroscience and Neural Engineering
- Prenatal Substance Exposure Effects
- Seismology and Earthquake Studies
- Anesthesia and Neurotoxicity Research
- Digestive system and related health
- Eicosanoids and Hypertension Pharmacology
- Neural dynamics and brain function
- Climate Change and Health Impacts
University of Otago
2014-2024
Gillies McIndoe Research Institute
2022-2024
New York University Press
2022
Cambridge University Press
2022
Brain Research New Zealand
2020
University of Auckland
2013-2019
University of Nottingham
2008-2013
University of Chicago
2012
Montana State University
2010
University of Minnesota
1993
Maternal high-fat or high-salt diets can independently program adverse cardiometabolic outcomes in offspring. However, there is a paucity of evidence examining their effects combination on metabolic function adult Female Sprague Dawley rats were randomly assigned to either: control (CD; 10% kcal from fat, 1% NaCl), (SD; 4% (HF; 45% NaCl) and salt (HFSD; 21 days prior mating throughout pregnancy lactation. Male offspring weaned onto standard chow diet culled postnatal day 130 for plasma...
Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration strengths and weaknesses any model disease is fundamental effective meaningful translation preclinical research. Studies sheep have made significant contributions our understanding normal abnormal development fetus. As a pregnancy, enabled scientists clinicians answer questions about etiology treatment poor maternal,...
Abstract Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non‐communicable disease later life: developmental origins health and (DOHaD) hypothesis. During 1990s validity DOHaD hypothesis was extensively tested a number human populations mechanisms underpinning it characterised range experimental animal models. past decade, researchers have sought to use this mechanistic understanding develop therapeutic...
Maternal obesity is associated with and metabolic disorders in offspring. However, intervention strategies to reverse or ameliorate the effects of maternal on offspring health are limited. Following undernutrition, taurine supplementation can improve outcomes offspring, possibly via glucose homeostasis insulin secretion. The mediating inflammatory processes as a protective mechanism has not been investigated. Further, efficacy setting known. Using model obesity, we examined related...
Maternal high fat and salt consumption are associated with developmental programming of disease in adult offspring. Inadequacies placental nutrient transport may explain these 'programmed effects'. Diet-induced inflammation have detrimental effects on function leading to alteration key transporters. We examined the maternal and/or diets markers inflammation. Sprague–Dawley rats were assigned (1) control (CD; 1% Salt 10% kcal from fat); (2) (SD; 4% salt, (3) (HF; 45% fat) or (4) (HFSD; 21...
Abstract More than 10% of babies are born too early resulting in over 15 million preterm births and more one new-born deaths globally. Although women with a previous spontaneous birth (SPTB) considered at high risk for recurrence, the majority occur without prior history. Prediction SPTB allows improved care potential targeting novel existing therapeutics to prevent SPTB, which may result outcomes infant mother. In this pilot study, miRNA array was used analyse plasma from healthy their...
Maternal high fat intake during pregnancy and lactation can result in obesity adverse cardio-metabolic status offspring independent of postnatal diet. While it is clear that maternal cause hypertension adult offspring, there little evidence regarding the role dietary interventions terms reversing these effects. Conjugated linoleic acid (CLA) an omega 6 fatty with beneficial effects metabolic status. However, impact CLA supplementation context disorders diet-induced developmental programming...
A high intake of fat or salt during pregnancy perturbs placental function, alters fetal development, and predisposes offspring to metabolic disease in adult life. Despite its relevance modern dietary habits, the developmental programming effects excessive maternal salt, fed combination, have not been examined. We investigated moderately and/or on metainflammation consequences weanling growth profile. Female Sprague-Dawley rats were a standard control diet (CD), 4% (SD), 45% (HF) salt/45%...
Maternal undernutrition results in elevated blood pressure (BP) and endothelial dysfunction adult offspring. However, few studies have investigated interventions during early life to ameliorate the programming of hypertension vascular disorders. We utilised a model maternal examine effects pre-weaning growth hormone (GH) treatment on BP function adulthood. Female Sprague-Dawley rats were fed either standard control diet (CON) or 50% CON intake throughout pregnancy (UN). From neonatal day 3...
Maternal diet can significantly skew the secondary sex ratio away from expected value of 0.5 (proportion males), but details how may do this are unclear. Here, we altered dietary levels salt (4% in feed) and/or fructose (10% drinking water) pregnant rats to model potential effects that consumption a "Western diet" might have on maternofetal growth, development, and ratio. We demonstrate excess before during pregnancy lead marked males, 0.60; P < 0.006). The effect was not mediated by...
A maternal high-fat (HF) diet during pregnancy can lead to metabolic compromise, such as insulin resistance in adult offspring. Skeletal muscle mitochondrial dysfunction is one mechanism contributing impairments resistant states. Therefore, the present study aimed investigate whether evident metabolically compromised offspring born HF-fed dams. Sprague-Dawley dams were randomly assigned receive a purified control (CD; 10% kcal from fat) or high fat (HFD; 45% for 10 days prior mating,...
It is well established that early-life nutritional alterations lead to increased risk of obesity and metabolic disorders in adult life. Although it clear gives rise chronic low-grade inflammation, there little evidence regarding the role inflammation adipose tissue undernourished (UN) offspring. GH reduces fat mass has antiinflammatory properties. The present study examined effect maternal UN on offspring whether treatment during a critical period developmental plasticity could ameliorate...
Maternal undernutrition (UN) is known to cause cardiac hypertrophy, elevated blood pressure, and endothelial dysfunction in adult offspring. UN may also lead disturbances GH regulation Because plays a key role development, we used model of maternal examine the effects neonatal treatment on micro RNA (miRNA) profiles, associated gene Female Sprague-Dawley rats were fed either standard control diet (CON) or 50% CON intake throughout pregnancy (UN). From day 3 until weaning (d 21), pups...
Maternal salt and fat intake can independently programme adult cardiovascular status, increasing risk of disease in offspring. Despite its relevance to modern western-style dietary habits, the interaction between increased maternal has not been examined. Female virgin Sprague-Dawley rats were fed, a standard control diet (CD) (10% kcal fat, 1% NaCl), High-fat (HF) (45% High-salt (SD) 4% high-salt (HFSD) NaCl) prior pregnancy, during pregnancy throughout lactation. Fetal, weanling vessels...
We examined whether maternal fish oil supplementation during pregnancy could prevent development of insulin resistance in adult male offspring rat dams fed a high-fat diet. Time-mated Sprague-Dawley were randomised into four treatment groups: Con-Con, control diet (fat: 15% kcal) and administered water by gavage; Con-FO, with unoxidised HF-Con, 45% HF-FO, gavage. Dams the allocated ad libitum lactation, but daily gavage occurred only pregnancy. After weaning, consumed chow until adulthood....
Maternal undernutrition (UN) is associated with the development of obesity and metabolic complications in adult offspring. While role inflammation related comorbidities has been well established, there little evidence regarding effects maternal UN-induced programming on immune function male This study examines growth hormone (GH), which known to induce anti-inflammatory effects, bone marrow macrophage (BMM) Sprague-Dawley rats were assigned chow (C) or UN (50% ad libitum; UN) diet throughout...
A maternal high-fat (HF) diet during pregnancy and lactation can result in adverse metabolic reproductive outcomes female offspring independent of postnatal diet. Interventions critical windows developmental plasticity may prevent programming offspring. The effects supplementation with the anti-inflammatory lipid conjugated linoleic acid (CLA) on early-onset puberty, dysfunction, estrous cycle dysfunction was assessed. Sprague-Dawley rats were randomly assigned to a purified control (CD; 10%...
Abstract The developmental origins of health and disease hypothesis proposes that an adverse early life environment, including in utero exposure to a maternal obesogenic can lead increased long-term risk obesity related metabolic complications offspring. We assessed whether supplementation with conjugated linoleic acid (CLA) could prevent some these effects offspring exposed high fat diet. Sprague-Dawley dams consumed either a: control (CD), CLA (CLA), (HF) or (HFCLA) diet 10 days prior...