A5061498706- Birth, Development, and Health
- Fatty Acid Research and Health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Gut microbiota and health
- Diabetes Management and Research
- Nutritional Studies and Diet
- Pancreatic function and diabetes
- Pregnancy and preeclampsia studies
- Antioxidant Activity and Oxidative Stress
- Adolescent and Pediatric Healthcare
- Sexual Differentiation and Disorders
- Diabetes and associated disorders
- Body Composition Measurement Techniques
- Nutrition and Health in Aging
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Thyroid Disorders and Treatments
- Plant Growth Enhancement Techniques
- Metabolism and Genetic Disorders
- Prenatal Substance Exposure Effects
- Eating Disorders and Behaviors
- Consumer Attitudes and Food Labeling
University of Auckland
2016-2025
John Radcliffe Hospital
2025
University of Oxford
2025
Starship Children's Health
2016-2022
Auckland District Health Board
2016-2019
Abstract We evaluated the quality and content of fish oil supplements in New Zealand. All encapsulated marketed Zealand were eligible for inclusion. Fatty acid was measured by gas chromatography. Peroxide values (PV) anisidine (AV) total oxidation (Totox) calculated. Only 3 32 contained quantities eicosapentaenoic (EPA) docosahexaenoic (DHA) that equal or higher than labelled content, with most products tested (69%) containing <67%. The vast majority exceeded recommended levels markers....
<h3>Importance</h3> Treatment of pediatric obesity is challenging. Preclinical studies in mice indicated that weight and metabolism can be altered by gut microbiome manipulation. <h3>Objective</h3> To assess efficacy fecal transfer (FMT) to treat adolescent improve metabolism. <h3>Design, Setting, Participants</h3> This randomized, double-masked, placebo-controlled trial (October 2017-March 2019) with a 26-week follow-up was conducted among adolescents aged 14 18 years body mass index (BMI;...
Abstract We assessed whether omega-3 index (red blood cell concentrations of eicosapentaenoic acid (EPA) and docosahexaenoic (DHA)) was associated with insulin sensitivity other metabolic outcomes in 47 overweight men aged 46.5 ± 5.1 years. Participants were twice, 16 weeks apart. Insulin by the Matsuda method from an oral glucose tolerance test. Linear associations examined; stratified analyses carried out participants separated according to index: lower tertiles (LOI; n = 31) highest...
We assessed the incidence of diabetic ketoacidosis (DKA) in children aged <15 years with newly diagnosed type 1 diabetes mellitus (T1DM) Auckland Region (New Zealand) 1999-2013, a retrospective review complete regional cohort. DKA and its severity were classified according to ISPAD 2014 guidelines. Of 730 presenting new-onset T1DM over 15-year time period, 195 cases had any (27%). There was no change or proportion severe at presentation. The among <2.0 (n = 40) 53% compared 25% for those...
Abstract Background Donor selection is an important factor influencing the engraftment and efficacy of fecal microbiota transplantation (FMT) for complex conditions associated with microbial dysbiosis. However, degree, variation, stability strain have not yet been assessed in context multiple donors. Methods We conducted a double-blinded randomized control trial FMT 87 adolescents obesity. Participants were to receive multi-donor (capsules containing four sex-matched lean donors) or placebo...
Recent reports suggest that the incidence of congenital hypothyroidism (CHT) is increasing in some countries. The etiology this change unclear, and it may relate to changes screening thresholds. We aimed determine whether CHT New Zealand has changed ethnic-specific rates subtypes have also changed.The neonatal TSH-based program prospectively identified cases using same assay thresholds since 1993. Thyroid scintiscans are routinely recommended. retrospectively all requiring levothyroxine...
Despite newborn screening and early levothyroxine replacement, there are continued reports of mild neurocognitive impairment in children with congenital hypothyroidism (CHT). In Auckland, New Zealand, cases identified by a neonatal program rapid institution high-dose replacement (10–15 μg/kg·d), producing prompt normalization thyroid function. Subsequently, frequent monitoring dose alterations performed for 2 years. We aimed to assess whether the Auckland treatment strategy prevents...
To explore the perspectives of Māori and Pacific women who participated in Fish Oil study to ascertain what barriers facilitators may exist for successfully recruiting into clinical trials. A Kaupapa qualitative study. Auckland, New Zealand. 16 fish oil supplementation during pregnancy (ACTRN12617001078347p) between 1 January 2017 31 December 2020. Semistructured in-depth interviews were conducted, recorded transcribed then subjected inductive thematic analysis identify key themes related...
ABSTRACT Objectives To assess the effectiveness of Dawes–Redman algorithm in identifying fetal wellbeing at term by analyzing 30 years retrospective clinical data, comparing normal and adverse pregnancy outcomes, evaluating key metrics testing its performance when used 0–48 h before delivery. Methods Antepartum heart rate (FHR) traces from singleton pregnancies 37 + 0 to 41 6 weeks' gestation obtained between 1991 2024 were extracted Oxford University Hospitals database. Traces with > 30%...
Abstract Aim Diabetes camps for children and adolescents living with Type 1 (T1D) offer an important opportunity to foster self‐efficacy ‘common humanity’, a sense that they are not alone in their challenges. The current study primarily aimed assess whether psychological wellbeing, diabetes self care behaviours HbA1c improved amongst campers caregivers, these would be sustained at 3‐ 6‐months. Methods Children aged 7–13 years who attended the 2023 camp Auckland, Aotearoa New Zealand one of...
We examined whether maternal fish oil supplementation during pregnancy could prevent development of insulin resistance in adult male offspring rat dams fed a high-fat diet. Time-mated Sprague-Dawley were randomised into four treatment groups: Con-Con, control diet (fat: 15% kcal) and administered water by gavage; Con-FO, with unoxidised HF-Con, 45% HF-FO, gavage. Dams the allocated ad libitum lactation, but daily gavage occurred only pregnancy. After weaning, consumed chow until adulthood....
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Abstract The prevalence of overweight and obesity amongst reproductive women has been increasing worldwide. Our aim was to compare pregnancy outcomes infant neurocognitive development by different BMI classifications investigate whether early associated with risks adverse in a Southwest Chinese population. We analysed data from 1273 enrolled the Complex Lipids Mothers Babies (CLIMB) randomized controlled trial Chongqing, China. Maternal classified as underweight, normal weight...
Background Maternal vitamin status preconception and during pregnancy has important consequences for outcome offspring development. Changes in from through early late postpartum have been inferred cross-sectional data, but longitudinal data on throughout postdelivery are sparse. As such, the influence of supplementation remains uncertain. This study presents one prespecified randomized controlled NiPPeR trial, aiming to identify patterns maternal preconception, pregnancy, 6 months...
Fish oil is commonly taken by pregnant women, and supplements sold at retail are often oxidized. Using a rat model, we aimed to assess the effects of supplementation with oxidized fish during pregnancy in mothers offspring, focusing on newborn viability maternal insulin sensitivity. Female rats were allocated control or high-fat diet then mated. These subsequently randomized receive daily gavage treatment 1 ml unoxidized oil, highly (water) throughout pregnancy. At birth, was stopped, but...
There has been little change in the incidence of diabetic ketoacidosis (DKA) newly diagnosed type 1 diabetes mellitus (T1DM) children and adolescents most developed countries.To assess potentially modifiable antecedents DKA <15 years age with new onset T1DM.Retrospective review prospectively collected data from a complete regional cohort T1DM Auckland (New Zealand) 2010 to 2014. severity were defined according ISPAD 2014 guidelines.A total 263 presented during 5-year study period at 9.0...
ISS is the commonest cause of short stature and poor growth arbitrarily defined as a height < -2 SDS without an identified cause. consists largely normal children with remainder unrecognised conditions, mainly syndromes genetic (monogenic polygenic) causes. Growth response to rhGH widely variable reflecting heterogeneity ISS. Further identification causes will better characterise treatment response. during childhood has been shown in RCTs improve adult by approximately 4 cm which less than...
Animal studies showed that germ-free mice inoculated with normal mouse gut bacteria developed obesity, insulin resistance and higher triglyceride levels, despite similar food intake. In humans, an association has been found between obesity microbiome dysbiosis. However, transfer not evaluated for the treatment of human obesity. We will examine effectiveness using encapsulated material in adolescents.A two-arm, double-blind, placebo-controlled, randomised clinical trial a single course be...
Optimal maternal vitamin status during pregnancy and lactation is essential to support infant health. For instance, D
Adrenocortical carcinoma (ACC) during childhood is a rare malignant tumor that frequently results in glucocorticoid and/or androgen excess. When there are signs of microscopic or macroscopic residual disease, adjuvant therapy recommended with mitotane, an adrenolytic and cytotoxic drug. In addition to the anticipated side effect adrenal insufficiency, mitotane known cause gynecomastia hypothyroidism adults. It has never been reported precocious puberty. A 4-year-old girl presented 6-week...