A5103063438- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- Immunotherapy and Immune Responses
- Veterinary Equine Medical Research
- Neonatal Respiratory Health Research
- Veterinary Pharmacology and Anesthesia
- Monoclonal and Polyclonal Antibodies Research
- Gas Dynamics and Kinetic Theory
- Cell Adhesion Molecules Research
- Neuroscience of respiration and sleep
- Acute Kidney Injury Research
- Melanoma and MAPK Pathways
- Cardiac Arrest and Resuscitation
- Computational Fluid Dynamics and Aerodynamics
- Cardiac, Anesthesia and Surgical Outcomes
- Heat shock proteins research
- Hemodynamic Monitoring and Therapy
- Nuclear Materials and Properties
- Protein Tyrosine Phosphatases
- Traumatic Brain Injury and Neurovascular Disturbances
- Blood Coagulation and Thrombosis Mechanisms
- Synthesis and biological activity
- Veterinary Medicine and Surgery
- Meat and Animal Product Quality
Massachusetts Institute of Technology
2023-2025
Charles Sturt University
2012-2025
MIT Lincoln Laboratory
2025
Inova Fairfax Hospital
2020-2024
Anesthesia Quality Institute
2023
Palo Alto University
2017
Stanford Medicine
2017
Novartis (France)
2016
Novartis Institutes for BioMedical Research
2016
Novartis (United States)
2016
Abstract Dendritic cells (DC) are potent APCs that enter resting tissues as precursors and, after Ag exposure, differentiate and migrate to draining lymph nodes. The phenotype of RelB knockout mice implicates this member the NF kappa B/Rel family in DC differentiation. To further elucidate role differentiation, mRNA, intracellular protein expression, DNA binding activity were examined immature differentiated human DC, well other PB mononuclear cell populations. mRNA detected constitutively...
The TMPRSS2:ERG gene fusion is common in androgen receptor (AR) positive prostate cancers, yet its function remains poorly understood. From a screen for functionally relevant ERG interactors, we identify the arginine methyltransferase PRMT5. recruits PRMT5 to AR-target genes, where methylates AR on 761. This attenuates recruitment and transcription of genes expressed differentiated epithelium. AR-inhibitory restricted TMPRSS2:ERG-positive cancer cells. Mutation this methylation site results...
Abstract Dendritic cells (DC) are the major APC in human peripheral blood (PB) and rheumatoid synovium. We previously identified PB a population of CD33dim-CD14dim DC precursors, as well smaller CD33bright CD14dim mature DC. Neither expressed CD28/CTLA4 ligands, suggesting that additional signals required for full functional differentiation. Because synovium is characterized by an ongoing immune response, expression function CD80, CD86, other markers differentiation arthritis synovial were...
Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market. Protein inhibition also significant potential a variety other diseases, including diabetes, pain, cognition, and chronic inflammatory immunologic diseases. However, as vast majority current approaches to target highly conserved ATP-binding site, use inhibitors in treating nononcology diseases may require great selectivity kinase. As are signal transducers that...
Objectives. The effect of massage therapy on chronic nonmigraine headache was investigated. Methods. Chronic tension sufferers received structured treatment directed toward neck and shoulder muscles. Headache frequency, duration, intensity were recorded compared with baseline measures. Results. Compared values, frequency significantly reduced within the first week protocol. reduction continued for remainder study (P = .009). duration headaches tended to decrease during period .058)....
Catheterisation of the urinary bladder is a common procedure during perioperative care horses. Benefits catheters include reduction in risk recovery‐associated slip hazards as consequence voided urine and measurement output anaesthesia. However, there little information regarding risks associated with this procedure. A retrospective cohort study was undertaken horses admitted to university teaching hospital for surgery which catheter placed perioperatively. Data were retrieved from clinical...
Abstract Loss of homologous recombination (HR), a core DNA damage repair pathway, is common in many types cancer that are caused by inactivating mutations BRCA1, BRCA2 and functionally related proteins. HR-deficient tumors widely treated with PARP inhibitors, but the duration response survival benefit often limited tolerability issues emergence clinical resistance mediated secondary restore HR activity. MOMA-313 novel, potent selective small molecule inhibitor polymerase theta (Polθ)...
We present a chemically-coupled thermoplasticity computational model for thermal protection systems. By employing unified discontinuous Galerkin numerical approach, the tightly couples chemical decomposition and pyrolysis gas transport with heat transfer solid mechanics problem, which contemplates large irreversible deformations. Modeling deformation of systems is crucial understanding potential failure mechanisms shields, as well distortion flight vehicle's aerodynamic surfaces. The...
Abstract IL-10 down-regulates the APC function of many dendritic cells (DC), including human peripheral blood (PB) DC. In rheumatoid arthritis (RA), synovial fluid (SF) DC express markers differentiation and are effective despite abundant IL-10. The regulation responsiveness to was therefore examined by comparing effect on normal PB RA SF Whereas down-modulated MHC class II B7 expression DC, had no such Since have differentiated in vivo presence proinflammatory cytokines, were cocultured...
We will describe our efforts to validate coupled thermo-chemo-mechanics material response code SumMIT against experiments of cylindrical samples PICA subject a range thermal loads produced by an oxyacetylene torch. The computational framework is extension the approach presented previously that incorporates models pyrolysis with thermoelastic response. Specifically, uses unified discontinuous Galerkin (DG) finite element discretization problem. provide temperature history data at various...
View Video Presentation: https://doi.org/10.2514/6.2023-0196.vid We propose a coupled thermo-chemo-mechanics numerical framework suitable for the description of material response to extreme aerospace environments. The approach is based on unified discontinuous Galerkin formulation equations describing solid mechanics, heat transfer, and chemical reaction problem. method effectively extends well-established Galerkin/cohesive zone model (DG/CZM) fracture in brittle solids multiphysics In...
In 2014, 56 Illinois hospitals came together to form a unique learning collaborative, the Surgical Quality Improvement Collaborative (ISQIC). Our objectives are provide an overview of first three years ISQIC focused on (1) how collaborative was formed and funded, (2) 21 strategies implemented support quality improvement (QI), (3) sustainment, (4) acts as platform for innovative QI research.
There have been recent calls to develop protocols that collect unambiguous measures of behaviour using automatic techniques in conditioning experiments on magnetic orientation. Here, we describe an automated technique for recording the Pekin ducks a test allows them express unrestricted searching behaviour. were trained find hidden food one corner square arena below which was placed coil produced local anomaly. The trigeminal nerve anaesthetised by injection lignocaine hydrochloride 2-3 mm...
In this work we present a computational framework for modeling thermo-chemo-mechanical material response in aerospace structures exposed to thermal and chemical ablation. Our approach is based on Lagrangian description of the solid mechanics that incorporates phenomenological models reactions within porous material. We adopt discontinuous Galerkin (DG) finite element discretization governing mechanics, heat transfer, reaction transport equations. As previously established, DG provides some...
Non-invasive ventilation (NIV) is a method of providing respiratory support without the need for airway intubation. The current study was undertaken to assess tolerance bi-nasal prongs and NIV in healthy, standing, lightly sedated foals. Bi-nasal were well tolerated by foals, remaining place allocated five minutes four six unsedated foals and, subsequently, All through prongs, although increasing pressures associated with increases inspiratory volume, duration inspiration air leakage most...