A5042319997- Colorectal Cancer Surgical Treatments
- Diverticular Disease and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Screening and Detection
- Innovations in Medical Education
- Surgical Simulation and Training
- Colorectal and Anal Carcinomas
- Diversity and Career in Medicine
- Patient Safety and Medication Errors
- Gastric Cancer Management and Outcomes
- Surgical site infection prevention
- Global Health Workforce Issues
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Hernia repair and management
- Medical Malpractice and Liability Issues
- Simulation-Based Education in Healthcare
- Cervical Cancer and HPV Research
- Healthcare Quality and Management
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Global Cancer Incidence and Screening
- Abdominal Surgery and Complications
Northwestern University
2015-2025
Anesthesia Quality Institute
2015-2023
Agency for Healthcare Research and Quality
2023
National Institutes of Health
2023
National Heart Lung and Blood Institute
2023
Northwestern Medicine
2017-2022
University of Illinois Chicago
2020
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2017-2020
Northwestern Memorial Hospital
2009-2019
American Society for Gastrointestinal Endoscopy
2004-2018
Identifying individuals with hereditary syndromes allows for improved cancer surveillance, risk reduction, and optimized management. Establishing criteria assessment the identification of who are carriers pathogenic genetic variants. The NCCN Guidelines Genetic/Familial High-Risk Assessment: Colorectal provide recommendations management patients high-risk colorectal syndromes. These Insights focus on evaluation Lynch syndrome considerations use multigene testing in
This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. syndrome common cause hereditary colorectal cancer, usually resulting from germline mutation in 1 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), deletions EPCAM promoter. Patients with are at an increased lifetime risk, compared general population, endometrial other cancers, including stomach ovary. As 2016, panel recommends screening all patients cancer provides...
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provide recommendations the management of patients with high-risk syndromes associated an increased risk colorectal cancer (CRC). Panel meets at least annually to assess comments from reviewers within their institutions, examine relevant data, and reevaluate update recommendations. These Insights focus on genes newly CRC multigene panels, evidence, currently recommended strategies.
A combination of factors has emphasized the need to reduce postoperative stay after surgery. Multimodal care plans may shorten hospital stay, but have been associated with high readmission rates and are generally reserved for straightforward, non-complicated colonic (not rectal) resections. This study evaluated a 'fast track' protocol in patients undergoing major rectal surgery.Sixty consecutive (median age 44.5 (range 13-70) years) underwent procedures over 6-week period on one colorectal...
T regs that expand in human colon cancer have proinflammatory properties and contribute to tumor progression.
The NCCN Guidelines for Colorectal Cancer (CRC) Screening outline various screening modalities as well recommended strategies individuals at average or increased-risk of developing sporadic CRC. panel meets least annually to review comments from reviewers within their institutions, examine relevant data, and reevaluate update recommendations. These Insights summarize 2018 updates the Guidelines, with a primary focus on used screen average-risk
T-regulatory cells (Treg) and mast (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions autoimmunity. Here, we demonstrate that both human CRC murine polyposis outcome this interaction generation potently suppressive but proinflammatory (ΔTreg). These shut down IL10, gain potential express IL17, switch from suppressing promoting MC expansion degranulation. This change also brought about by direct...
Mortality from colorectal cancer can be reduced by early diagnosis and prevention through polypectomy. These NCCN Guidelines for Colorectal Cancer Screening describe various screening modalities recommended schedules patients at average or increased risk of developing cancer. In addition, the guidelines provide recommendations management with high-risk syndromes, including Lynch syndrome. approaches syndrome are also described.
The NCCN Guidelines for Colorectal Cancer (CRC) Screening describe various colorectal screening modalities as well recommended schedules patients at average or increased risk of developing sporadic CRC. They are intended to aid physicians with clinical decision-making regarding CRC without defined genetic syndromes. These Insights focus on select recent updates the Guidelines, including a section primary and secondary prevention, provide context panel’s recommendations age initiate in...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Colorectal Cancer Screening provide recommendations selecting individuals colorectal cancer screening, and evaluation follow-up of colon polyps. These Insights summarize major discussion points the 2015 panel meeting. Major topics this year were state evidence CT colonography stool DNA testing, bowel preparation procedures colonoscopy, guidelines patients with a positive family history cancer.
PURPOSE: The objective of this study was to assess survival and prognostic factors for anal carcinoma in the population. METHODS: Patients with squamous-cell canal were identified from National Cancer Data Base (1985-2000). Univariate multivariable methods used associated survival. Concordance calculated agreement between American Joint Committee on stage actual outcome. RESULTS: Nineteen thousand one hundred ninety-nine patients (Stage I, 25.3 percent; Stage II, 51.8 III, 17.1 IV, 5.7...
This study aimed to report at ten years on the results of same cohort that had been studied five who undergone an anal sphincter repair for fecal incontinence.Patients were contacted after and asked fill out Fecal Incontinence Quality Life Scale, Severity Index, Bristol Stool Form Scale.Thirty-one 44 (71 percent) patients contacted. Median follow-up time was 129 (range, 113 208) months. age surgery 22 80) years. No fully continent Index scores correlated with surgery. Older lower (P =...
PURPOSE: Primary small-bowel adenocarcinoma is uncommon. There are few large studies that have evaluated the prognostic impact of clinical and pathologic parameters. The purpose this study was to perform a comprehensive analysis Cleveland Clinic experience with adenocarcinoma, emphasis on histopathologic parameters as indicators. METHODS: Thirty-seven cases primary adenocarcinomas resected at between 1978 1999 were retrospectively studied. Metastatic tumors those arising from biliary system...
The oblique rectus abdominal myocutaneous flap is a seldom used design based on perforating vessels exiting the near umbilicus. Compared to other flaps, provides increased soft tissue fill pelvic dead space, with further advantage of intact skin close perineal defects. Here we detail in achieving closure complex wounds.A review indications and outcomes 16 patients undergoing operations requiring reconstruction this was undertaken.All had been previously treated irradiation for cancer....