A5005816648- Veterinary Pharmacology and Anesthesia
- Veterinary Equine Medical Research
- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Anesthesia and Sedative Agents
- Pharmacological Effects and Assays
- Antibiotics Pharmacokinetics and Efficacy
- Opioid Use Disorder Treatment
- Veterinary Orthopedics and Neurology
- Human-Animal Interaction Studies
- Veterinary Practice and Education Studies
- Animal Nutrition and Physiology
- Thermal Regulation in Medicine
- Animal testing and alternatives
- Hemodynamic Monitoring and Therapy
- Pediatric Pain Management Techniques
- Reproductive Physiology in Livestock
- Invertebrate Taxonomy and Ecology
- Anesthesia and Neurotoxicity Research
- Analytical Chemistry and Sensors
- Inflammatory mediators and NSAID effects
- Pain Management and Opioid Use
- Hormonal and reproductive studies
- Cardiac Ischemia and Reperfusion
- Neuroendocrine regulation and behavior
British Veterinary Association
2020-2024
Glasgow Life
2023-2024
Taylor Wimpey (United Kingdom)
2006-2024
Max Fordham (United Kingdom)
2021
American College of Veterinary Internal Medicine
2020
MRC Epidemiology Unit
2020
London School of Hygiene & Tropical Medicine
2020
Université de Montréal
2018
At Bristol
2004-2011
Animal Health Trust
1990-2009
The pharmacokinetics and thermal antinociceptive effects of buprenorphine after intravenous (i.v.) or oral transmucosal (OTM) administration were studied in six adult cats. Plasma concentrations measured using radioimmunoassay a crossover study dose 20 μ g/kg given by the i.v. OTM route. Oral pH was measured. Blood for drug analyses collected before, at 1, 2, 4, 6, 10, 15, 30, 60 min 8, 12, 24 h treatment. Thermal thresholds before treatment, then following treatment every 30 to 6 h, 1 hour...
Summary Reasons for performing study : Approximately 1 in 100 horses suffer unexpectedly from anaesthetic‐related death. Identification and use of the safest anaesthetic drugs should support this aim. Experimental evidence has suggested that isoflurane be a safer maintenance agent equine anaesthesia than halothane. Hypothesis The death rate would reduced being maintained with compared to Methods A multicentre randomised controlled trial was undertaken compare effects halothane all types...
Summary Detomidine, given intravenously at doses of 5 to 30 (mean 13) μ/kg bodyweight (bwt), provided adequate sedation for a variety clinical procedures in 93 per cent administrations, and improved the ease handling remaining animals. Side effects ataxia bradycardia were minimal lower dose rates. Higher required intramuscular use. In experimental trials 10 20 μg/kg bwt resulted deep also significant hypertension over 15 mins duration. Current literature on use detomidine horses is reviewed.
NSAIDS AND CATS: Non-steroidal anti-inflammatory drugs (NSAIDs) are an important class of drug in feline medicine, having analgesic, and antipyretic activity. While most published data on their use this species relate to short-term (often perioperative) therapy, there is increasing evidence the value these treating chronic pain cats (for example, that associated with degenerative joint disease), some NSAIDs have now become licensed for long-term geographies. Most our knowledge therapeutic...
To estimate the effect of maternal illicit and prescription drug use on neonates in Washington State between 2000 2008.We used state-linked birth certificate hospital discharge (mother neonate) data to calculate prenatal exposure neonatal abstinence syndrome rates, compared state rates with national-level from Nationwide Inpatient Sample. We identified drugs exposure, examined predictors syndrome, assessed perinatal outcomes among drug-exposed syndrome-diagnosed unexposed neonates.Drug...
Effects of tramadol and acepromazine on pressure thermal thresholds were examined in eight cats. After baseline measurements, subcutaneous (SC) 1 mg/kg, 0.1 mg/kg with or saline 0.3 ml given. Serial measurements made for 24 h. Mean did not change significantly [analysis variance (ANOVA)] from baseline. The maximum threshold increase above was 2.8+/-2.8 degrees C at 6 h (P>0.05) after tramadol; it the 95% confidence interval (CI) 0.75, 3 Pressure increased 0.25 to 2 (P<0.05) 0.5 combination...
Eighty‐four female cats undergoing ovariohysterectomy in a blinded, randomised, prospective clinical study were assigned to one of three groups 28 receive either 0.01 mg/kg buprenorphine (group B), 4 mg/ kg carprofen C), or the same doses both drugs BC). A dynamic and interactive visual analogue scale (DIVAS) from 0 100 mm, simple descriptive (SDS) used evaluate cats’ degree analgesia sedation for 24 hours postoperatively. There was no significant difference scores by SDS DIVAS, their pain...
ABSTRACT The efficacy of buprenorphine and pentazocine in controlling pain dogs following orthopaedic surgery was compared with that morphine. All three analgesics provided effective relief no undesirable side effects.
Summary Reasons for performing study: To investigate the antinociceptive effects of buprenorphine administered in combination with acepromazine horses and to establish an effective dose use a clinical environment. Objectives: evaluate responses thermal mechanical stimulation following administration 3 doses compared positive (butorphanol) negative (glucose) controls. Methods: Observer blinded, randomised, crossover design using 6 Thoroughbred geldings (3–10 years, 500–560 kg). Thermal...
One hundred female cats undergoing routine ovariohysterectomy under midazolam-medetomidine-ketamine anaesthesia were included in a blinded, randomised, prospective clinical study to compare postoperative analgesia produced by four analgesic drug combinations given preoperatively (n = 25 per group). A secondary aim was assess the effects kittens and pregnant animals. Buprenorphine 180 µg/m 2 or butorphanol 6 mg/m with either carprofen 4 mg/kg (groups BUPC BUTC, respectively) meloxicam 0.3...
Quantification of pain plays a vital role in the diagnosis and management animals. In order to refine validate an acute scale for horses prospective, randomized, blinded study was conducted. Twenty-four client owned adult were recruited allocated one four following groups: anaesthesia only (GA); pre-emptive analgesia (GAA,); anaesthesia, castration postoperative (GC); or analgesia, (GCA). One investigator, unaware treatment group, assessed all at time-points before after intervention...
Drug policy, whether for legal or illegal substances, is a controversial field that encompasses many complex issues. Policies can have effects on myriad of outcomes and stakeholders differ in the they consider value, while relevant knowledge policy dispersed across multiple research disciplines making integrated judgements difficult.Experts drug harms, addiction, criminology were invited to decision conference develop multi-criterion analysis (MCDA) model appraising alternative regulatory...
Modern veterinary medicine offers numerous options for treatment and clinicians must decide on the best one to use. Interventions causing short-term harm but ultimately benefitting animal are often justified as being in animal's interest. Highly invasive clinical procedures with high morbidity low success rates may not be A working party was set up by European College of Veterinary Anaesthesia Analgesia discuss ethics practice improve approach ethically challenging cases. Relevant literature...
It is almost 20 years since the largest observational, multicentre study evaluating risks of mortality associated with general anaesthesia in horses. We proposed an internet-based method to collect data (cleaned and analysed R) a multicentre, cohort, analytical, longitudinal prospective evaluate peri-operative equine mortality. The objective was report usefulness method, illustrated preliminary data, including outcomes for horses seven days after undergoing certain procedures using standing...
The optimum dose of dexmedetomidine for antinociception to a thermal stimulus was determined in crossover study 12 cats. In five treatment groups ( n = 10 per group), administered intramuscularly (i.m.) at 2, 5, 10, 20 and 40 μg/kg; positive negative controls were buprenorphine (20 μg/kg, i.m.) 0.9% saline (0.006 mL/kg, respectively. Baseline thresholds visual analogue scale (VAS) sedation scores obtained prior drug then regular intervals until 24 h after administration. summary measures...