A5034406682- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Pregnancy and preeclampsia studies
- Infant Nutrition and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Development and Preterm Care
- Genetic Syndromes and Imprinting
- Pregnancy-related medical research
- Gestational Trophoblastic Disease Studies
- Ethics and Legal Issues in Pediatric Healthcare
- Genital Health and Disease
- Congenital Heart Disease Studies
- Neonatal and fetal brain pathology
- Anesthesia and Neurotoxicity Research
- Pregnancy and Medication Impact
- Prenatal Screening and Diagnostics
- Neuroscience of respiration and sleep
- Drug Transport and Resistance Mechanisms
- Childhood Cancer Survivors' Quality of Life
- Respiratory Support and Mechanisms
- Female Genital Mutilation/Cutting Issues
Tohoku University Hospital
2016-2025
National University of Singapore
2024-2025
National University Health System
2024
Antenatal steroid therapy for fetal lung maturation is routinely administered to women at risk of preterm delivery. There strong evidence demonstrate benefit from antenatal steroids in terms survival and respiratory disease, notably infants delivered or below 32 weeks' gestation. However, dosing remains unoptimized benefits are highly variable. Current treatment regimens generate high-concentration, pulsatile exposures now associated with increased childhood neurodevelopmental diseases. We...
Abstract Background Antenatal steroid (ANS) therapy is given to women at risk of preterm delivery accelerate fetal lung maturation. However, the benefit ANS variable and how maternal factors contribute this observed variability unknown. We aimed test degree concordance in function, correlate with genomic, transcriptomic, pharmacokinetic variables dizygotic twin ovine fetuses. Methods Thirty-one date-mated ewes carrying fetuses 123 ± 1 days’ gestation received intramuscular injections either...
The use of antenatal corticosteroids (ACS) in low-resource environments is sporadic. Further, drug choice, dose, and route ACS are not optimized. We report the pharmacokinetics pharmacodynamics oral dosing using a preterm sheep model. measured betamethasone-phosphate (Beta-P) dexamethasone-phosphate (Dex-P) catheterized pregnant sheep. compared fetal lung maturation responses Beta-P Dex-P to standard treatment with 2 doses i.m. mixture betamethasone-acetate at 2, 5, 7 days after initiation...
Antenatal steroid therapy is the standard of care for women at imminent risk preterm delivery. Current dosing regimens use suprapharmacological doses to achieve extended fetal exposures. We aimed determine lowest plasma betamethasone concentration sufficient functional lung maturation. Ewes with single fetuses underwent surgery install a jugular catheter. Adopting stepwise design, ewes were randomized either saline-only group (negative control group; n = 9) or one four treatment groups. Each...
Objective Extremely preterm infants have low Nuclear Receptor (NR) expression in their developing hepatobiliary systems, as they rely on the placenta and maternal liver for compensation. NRs play a crucial role detoxification elimination of both endogenous xenobiotic substances by regulating key genes encoding specific proteins. In this study, we utilized an Artificial Placenta Therapy (APT) platform to examine tissue extremely ovine fetuses. This fetal model, resembling "knockout placenta,"...
Background Intraamniotic inflammation is associated with up to 40% of preterm births, most notably in deliveries occurring prior 32 weeks’ gestation. Despite this, there are few treatment options allowing the prevention birth and fetal injury. Recent studies have shown that small, non-competitive allosteric interleukin (IL)-1 receptor inhibitor, rytvela, may be use resolving (PTB) We aimed an extremely sheep model chorioamnionitis investigate anti-inflammatory efficacy rytvela response...
Introduction: Artificial placenta therapy (APT) is an experimental life support system to improve outcomes for extremely preterm infants (EPI) less than 1,000 g by obviating the need pulmonary gas exchange. There are presently no long-term survival data EPI supported with APT. To address this, we aimed maintain 95d-GA (GA; term-150d) sheep fetuses up 2 weeks using our APT system. Methods: Pregnant ewes (n = 6) carrying singleton underwent surgical delivery at 95d GA. Fetuses were adapted and...
Abstract Despite widespread use, dosing regimens for antenatal corticosteroid (ACS) therapy are poorly unoptimized. ACS exerts a programming effect on fetal development, which may be associated with an increased risk of cardiovascular disease. Having demonstrated that low-dose steroid is efficacious means maturing the preterm lung, we hypothesized exposure would exert fewer adverse functional and transcriptional changes heart. We tested this hypothesis using (10 mg delivered to ewe over 36 h...
Intrauterine inflammation, a representative stressor for the fetus, has been shown to alter hypothalamus-pituitary-adrenal (HPA) axis reactivity in preterm fetuses and increase postnatal cortisol production. However, mechanism of this alteration not yet elucidated.We aimed clarify effects endotoxin-induced intrauterine inflammation on HPA periviable sheep fetuses.Fetal (0.63 term) were divided into 2 groups: (1) endotoxin group, which was injected amniotic fluid; (2) control saline solution...
Artificial placenta therapy (APT) is an experimental care strategy for extremely preterm infants born at 21-24 weeks' gestation. In our previous studies, blood taken from the maternal ewe was used as basis of priming solutions artificial circuit. However, use a solution accompanied by several challenges. We explored synthetic red cells (hemoglobin vesicles; HbV) APT to manage early ovine fetuses. Six ewes with singleton pregnancies 95 d gestation (term = 150 d) were adapted and maintained...
Labial fusion is defined as adhesions of the labia minora or majora. may cause urinary retention. Surgical treatment based on an accurate anatomic assessment be needed, but usefulness endoscopic examination for this disease has not been reported.A 76-year-old Japanese woman undergoing chemoradiation esophageal cancer was referred to our department evaluation high accumulation in vagina a positron emission tomography scan. On physical examination, her were noted extensively fused with pinhole...