A5029681621- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Pregnancy and preeclampsia studies
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Muscle Physiology and Disorders
- Milk Quality and Mastitis in Dairy Cows
- Maternal and fetal healthcare
- Drug Transport and Resistance Mechanisms
- Simulation-Based Education in Healthcare
- Congenital Anomalies and Fetal Surgery
- Public Health Policies and Education
- Uterine Myomas and Treatments
- Gender Roles and Identity Studies
- Machine Learning in Healthcare
- Pregnancy and Medication Impact
- Mesenchymal stem cell research
- Gynecological conditions and treatments
- Spaceflight effects on biology
- Pregnancy-related medical research
- Anesthesia and Neurotoxicity Research
The University of Western Australia
2019-2025
Women and Infants Research Foundation
2025
Tufts Children's Hospital
2022
Tufts Medical Center
2022
Natural language processing is a form of artificial intelligence that allows human users to interface with machine without using complex codes. The ability natural systems, such as ChatGPT, successfully engage healthcare systems requiring fluid reasoning, specialist data interpretation, and empathetic communication in an unfamiliar evolving environment poorly studied. This study investigated whether the ChatGPT could complete mock objective structured clinical examination simulating...
Antenatal steroid therapy for fetal lung maturation is routinely administered to women at risk of preterm delivery. There strong evidence demonstrate benefit from antenatal steroids in terms survival and respiratory disease, notably infants delivered or below 32 weeks' gestation. However, dosing remains unoptimized benefits are highly variable. Current treatment regimens generate high-concentration, pulsatile exposures now associated with increased childhood neurodevelopmental diseases. We...
Mechanical ventilation from birth with normal tidal volumes (V
Abstract Background Antenatal steroid (ANS) therapy is given to women at risk of preterm delivery accelerate fetal lung maturation. However, the benefit ANS variable and how maternal factors contribute this observed variability unknown. We aimed test degree concordance in function, correlate with genomic, transcriptomic, pharmacokinetic variables dizygotic twin ovine fetuses. Methods Thirty-one date-mated ewes carrying fetuses 123 ± 1 days’ gestation received intramuscular injections either...
Antenatal corticosteroid therapy is a standard of care for women at imminent risk preterm labor. However, the optimal (maximum benefit and minimal side effects) antenatal dosing strategy remains unclear. Although conveying overall when given to right patient time, treatment efficacy highly variable not risk-free. Building on earlier findings, we hypothesized that administered in combination with slow-release betamethasone acetate, phosphate high maternal-fetal concentrations it generates are...
The use of antenatal corticosteroids (ACS) in low-resource environments is sporadic. Further, drug choice, dose, and route ACS are not optimized. We report the pharmacokinetics pharmacodynamics oral dosing using a preterm sheep model. measured betamethasone-phosphate (Beta-P) dexamethasone-phosphate (Dex-P) catheterized pregnant sheep. compared fetal lung maturation responses Beta-P Dex-P to standard treatment with 2 doses i.m. mixture betamethasone-acetate at 2, 5, 7 days after initiation...
Antenatal steroids (ANSs) are routinely administered to women judged be at imminent risk of preterm delivery. Their principal benefit is precocious functional maturation the fetal lung. Current dosing regimens expose mother and fetus high steroid levels that may unnecessary, increasing potential risks disruption maternal hypothalamic-pituitary-adrenal (HPA) axis glucose regulation, alterations in placental function, reduced growth. Using a sheep model pregnancy, we tested hypothesis direct...
Antenatal steroid therapy is the standard of care for women at imminent risk preterm delivery. Current dosing regimens use suprapharmacological doses to achieve extended fetal exposures. We aimed determine lowest plasma betamethasone concentration sufficient functional lung maturation. Ewes with single fetuses underwent surgery install a jugular catheter. Adopting stepwise design, ewes were randomized either saline-only group (negative control group; n = 9) or one four treatment groups. Each...
Background Intraamniotic inflammation is associated with up to 40% of preterm births, most notably in deliveries occurring prior 32 weeks’ gestation. Despite this, there are few treatment options allowing the prevention birth and fetal injury. Recent studies have shown that small, non-competitive allosteric interleukin (IL)-1 receptor inhibitor, rytvela, may be use resolving (PTB) We aimed an extremely sheep model chorioamnionitis investigate anti-inflammatory efficacy rytvela response...
Objective Extremely preterm infants have low Nuclear Receptor (NR) expression in their developing hepatobiliary systems, as they rely on the placenta and maternal liver for compensation. NRs play a crucial role detoxification elimination of both endogenous xenobiotic substances by regulating key genes encoding specific proteins. In this study, we utilized an Artificial Placenta Therapy (APT) platform to examine tissue extremely ovine fetuses. This fetal model, resembling "knockout placenta,"...
Abstract Human Wharton’s jelly stem cells (hWJSCs) are multipotent that extensively employed in biotechnology applications. However, the impact of simulated lunar microgravity (sμG) on growth, differentiation, and viability this cell population is incompletely characterized. We aimed to determine whether acute (72 h) exposure sμG elicited changes growth lineage differentiation hWJSCs if putative were maintained once terrestrial gravity (1.0 G) was restored. cultured under standard 1.0 G...