A5075980805- Reproductive System and Pregnancy
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Streptococcal Infections and Treatments
- Ginger and Zingiberaceae research
- Ginseng Biological Effects and Applications
- Reproductive Physiology in Livestock
- Medicinal Plants and Bioactive Compounds
- Plant responses to water stress
- Immune responses and vaccinations
- Heavy Metal Exposure and Toxicity
- IL-33, ST2, and ILC Pathways
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Ultrasound and Hyperthermia Applications
- Bioactive natural compounds
- Inflammation biomarkers and pathways
- Environmental Toxicology and Ecotoxicology
- Neonatal and Maternal Infections
- Bioactive Compounds and Antitumor Agents
- Berberine and alkaloids research
- Garlic and Onion Studies
- Chromatography in Natural Products
Huazhong Agricultural University
2015-2024
First Affiliated Hospital of Zhengzhou University
2020-2024
Beijing Institute of Technology
2024
Chongqing Medical University
2022
First People's Hospital of Chongqing
2022
University of Macau
2021
Ocean University of China
2019-2020
Sichuan Agricultural University
2018
Hyperoside (quercetin 3-o-β-d-galactopyranoside) is one of the flavonoid glycosides with anti-inflammatory, antidepressant, and anti-cancer effects. But it remains unknown whether had effects on breast cancer. Here, different concentrations hyperoside were used to explore its therapeutic potential in both cancer cells subcutaneous homotransplant mouse model. CCK-8 wound healing assays showed that viability migration capability Michigan Cancer Foundation-7 (MCF-7) 4T1 inhibited by hyperoside,...
Acute lung injury (ALI) which is featured by a strong pulmonary inflammation, major cause of morbidity and mortality in critically ill patients. Recent studies have shown that magnoflorine has certain anti-inflammatory effect, whereas the effect on lipopolysaccharide (LPS)-induced ALI mice not been reported. The purpose present study to investigate LPS-induced elucidate its possible molecular mechanisms RAW264.7 cells. results histopathological changes as well myeloperoxidase (MPO) activity...
Abnormal inflammatory bias in the maternal-fetal interface leads to reproductive failure mammals. Placental exosomes are involved communication during pregnancy. However, whether placenta or fetus is regulating balance of uterine local inflammation through remains unclear, and mechanism must be further explored. Here we demonstrated that placenta-specific abundant peripheral blood dairy cows early pregnancy selectively load miRNAs, such as bta-miR-499. In vitro, placental exosome-derived...
Abstract Endometritis is a postnatal reproductive disorder disease, which leads to great economic losses for the modern dairy industry. Emerging evidence indicates that microRNAs (miRNAs) play pivotal role in variety of diseases and have been identified as critical regulators innate immune response. Recent miRNome profile analysis revealed an altered expression level miR‐148a cows with endometritis. Therefore, present study aims investigate regulatory response involved endometritis estimate...
Amino acid metabolic pathways can have profound impacts on the activities of key enzymes in biosynthesis specific aroma compounds during yeast fermentation. Aroma compounds, pyruvic and glucose were monitored relation to leucine aminotransferase (LTR), phenylalanine (PAL), pyruvate kinase (PK) acetyl-CoA amino fermentation simulated juice systems with added acids order explore formation characteristic compounds. The addition L-phenylalanine or L-leucine significantly improved PK, PAL LTR,...
ABSTRACT Infection with highly pathogenic Streptococcus suis can cause septic shock, which is characterized by high levels of inflammatory cytokines and a mortality rate. Our previous study indicated that TREM-1 (triggering receptor expressed on myeloid cells 1) was upregulated in swine spleen response to S. infection. The role signaling enhancement the proinflammatory promoted us examine its effect outcome In present study, recombinant extracellular domain (rTREM-1) an agonistic antibody...
We fabricated an ultrasound activated 'nanobomb' as a noninvasive and targeted physical therapeutic strategy for sonodynamic therapy priming cancer immunotherapy. This was rationally designed via the encapsulation of indocyanine green (ICG) perfluoropentane (PFP) into cRGD peptide-functionalized nano-liposome. The resulting Lip-ICG-PFP-cRGD nanoparticle linked with peptide could actively ID8 TC-1 cells elicits ROS-mediated apoptosis after triggered by low-intensity focused (LIFU). Moreover,...
Streptococcus suis (S. suis) ranks among the five most important porcine pathogens worldwide and occasionally threatens human health, especially in people that come into close contact with pigs or pork products. serotype 2 (SS2) is considered to be pathogenic prevalent capsular type. As a first line of immune defense against SS2 infection, neutrophils can eliminate invader not only by phagocytosis but also neutrophil extracellular traps (NETs)-mediated killing. resist through polysaccharide...
Streptococcus suis (S. suis), a major swine pathogen, is also severe threat to human health. Infection with highly virulent strains of S. can cause Streptococcal toxic-shock-like syndrome (STSLS), which associated high serum pro-inflammatory cytokine levels and mortality rate. Our previous study indicated that infection could activate the TREM-1 signaling pathway, promotes host clearance during early infection. However, it remained be elicited whether target against STSLS in presence...
Abstract Acute lung injury (ALI) is a severe acute inflammatory reaction of the lungs caused by variety factors, which can lead to high mortality rate. MicroRNAs are novel therapeutic molecule that play vital role in many diseases. However, its mechanism action lipopolysaccharide (LPS)‐induced mouse ALI not clear. The study aimed investigate miR‐497 LPS‐induced ALI. As result, it was found expression showed decrease time and dose trends. Importantly, reduced levels related factors. In...
The resistance to Heterodera glycines 1 (Rhg1) locus is widely used by soybean breeders reduce yield loss caused cyst nematode (SCN). α-SNAP (α-soluble NSF attachment protein) within Rhg1 contributes SCN modulation of cell status at the feeding site; however, underlying mechanism largely unclear. Here, we identified an α-SNAP-interacting protein, GmSYP31A, a Qa-SNARE (soluble protein receptor) from soybean. Expression GmSYP31A significantly induced death in Nicotiana benthamiana leaves, and...
Abstract Staphylococcus aureus ( S. )‐induced mastitis is the most frequent, pathogenic, and prevalent infection of mammary gland. The ligand growth arrest‐specific 6 (Gas6) a secretory protein that binds to activates Tyro3, Axl, MerTK receptors. This study explored role Gas6 in ‐induced mastitis. Our results revealed TLR receptors initiate innate immune response gland tissues epithelial cells introducing TLR2 TLR6 drive multiple intracellular mitogen‐activated kinase (MAPK) nuclear factor...
Sodium houttuyfonate (SH) has been indicated to play an important anti‑inflammatory role. Previous studies have confirmed that SH can inhibit the NF‑κB pathway in lipopolysaccharide (LPS)‑induced mastitis bovine mammary epithelial cells. However, effects of on LPS‑induced animals should be verified further evaluate its actual value. In present study, were investigated mouse models and a cell line. Hematoxylin eosin staining (H&E) showed therapy significantly alleviated pathological changes...