A5100606881- High-Temperature Coating Behaviors
- Metal and Thin Film Mechanics
- High Entropy Alloys Studies
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Tribology and Wear Analysis
- Diamond and Carbon-based Materials Research
- Nanoplatforms for cancer theranostics
- RNA Research and Splicing
- Metallic Glasses and Amorphous Alloys
- Metal Alloys Wear and Properties
- Immune cells in cancer
- Advanced materials and composites
- Histone Deacetylase Inhibitors Research
- RNA Interference and Gene Delivery
- Genomics and Phylogenetic Studies
- interferon and immune responses
- Extracellular vesicles in disease
- Protein Degradation and Inhibitors
- Advanced ceramic materials synthesis
- Connexins and lens biology
- Advanced Materials Characterization Techniques
- Heat shock proteins research
- Additive Manufacturing Materials and Processes
Huashan Hospital
2017-2025
Fudan University
2017-2025
First Affiliated Hospital of Henan University
2024-2025
China Astronaut Research and Training Center
2019-2024
Fujian Agriculture and Forestry University
2024
Hungkuang University
2013-2024
Harvard University
2023-2024
Brigham and Women's Hospital
2023-2024
Second Affiliated Hospital of Zhejiang University
2023-2024
Xinjiang Medical University
2024
The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy use tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome stromal barrier for management triple-negative breast cancer (TNBC). SnSNPs possess narrow bandgap (1.18 eV), allowing efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More...
Tumor-associated macrophages (TAMs) play a critical role in the immunosuppressive solid tumor microenvironment (TME), yet situ engineering of TAMs for enhanced immunotherapy remains significant challenge translational immuno-oncology. Here, we report an innovative nanodrug-delivering-drug (STNSP@ELE) strategy that leverages two-dimensional (2D) stanene-based nanosheets (STNSP) and β-Elemene (ELE), small-molecule anticancer drug, to overcome TAM-mediated immunosuppression improve...
Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss in elderly population. With aging and accumulated effects environmental stress, retinal pigment epithelial (RPE) cells are particularly susceptible to oxidative damage, which can lead degeneration. However, underlying molecular mechanisms how RPE responds progresses under damage still largely unknown. Here, we reveal that exogenous stress led ferroptosis characterized by Fe
A growing body of evidence suggests that long-chain non-coding RNA (lncRNA) plays an important role in the malignant biological behavior and drug resistance glioblastoma (GBM) cells. In this study, we analyzed potential mechanism lncRNA TMEM161B-AS1 GBM cells temozolomide (TMZ) resistance. Studies have found FANCD2 CD44 are significantly related to occurrence GBM, TMZ survival patients. Knockdown down-regulated expression by sponging hsa-miR-27a-3p, inhibited proliferation, migration,...
Background: Circulating exosomal microRNAs (miRNAs) are considered as potentially non-invasive biomarkers for early detection and prognosis of cancers. Due to the lack highly sensitive specific molecular markers, a lot patients with hepatocellular carcinoma diagnosed in advanced stages. This study aims explore expression mode clinical value serum miR-34a HCC, providing new potential targets theoretical basis diagnosis monitoring carcinoma. Methods: The 60 HCC before after operation healthy...
Macroautophagy/autophagy is an essential cellular response in the fight against intracellular pathogens. Although some viruses can escape from or utilize autophagy to ensure their own replication, responses of pathways viral invasion remain poorly documented. Here, we show that peste des petits ruminants virus (PPRV) infection induces successive autophagic signalling host cells via distinct and uncoupled molecular pathways. Immediately upon invasion, PPRV induced a first transient wave...