A5064540403- Parasite Biology and Host Interactions
- Plant Virus Research Studies
- Chromosomal and Genetic Variations
- Advances in Cucurbitaceae Research
- Plant Reproductive Biology
- Plant Disease Resistance and Genetics
- Plant Molecular Biology Research
- Nematode management and characterization studies
- Cocoa and Sweet Potato Agronomy
- Genomics and Phylogenetic Studies
- Peripheral Nerve Disorders
- Aquatic Invertebrate Ecology and Behavior
- Mollusks and Parasites Studies
- Plant Gene Expression Analysis
- Plant Pathogens and Fungal Diseases
- Marine Ecology and Invasive Species
- Gut microbiota and health
- Plant Pathogenic Bacteria Studies
- Pain Mechanisms and Treatments
- Planarian Biology and Electrostimulation
- Plant Physiology and Cultivation Studies
- Polysaccharides Composition and Applications
- Environmental DNA in Biodiversity Studies
- Plant biochemistry and biosynthesis
- Botulinum Toxin and Related Neurological Disorders
Cornell University
2017-2025
Ithaca College
2020-2024
Guangdong Pharmaceutical University
2021-2024
Fujian Medical University
2023-2024
Shanghai Sixth People's Hospital
2021-2024
Shanghai Jiao Tong University
2021-2024
Fujian Agriculture and Forestry University
2023
Southern Medical University
2017-2023
Affiliated Hospital of Guizhou Medical University
2017-2022
Guiyang Medical University
2017-2022
The Cucurbita genus contains several economically important species in the Cucurbitaceae family. Here, we report high-quality genome sequences of C. maxima and moschata provide evidence supporting an allotetraploidization event Cucurbita. We are able to partition into two homoeologous subgenomes based on different genetic distances melon, cucumber, watermelon Benincaseae tribe. estimate that diploid progenitors successively diverged from around 31 26 million years ago (Mya), respectively,...
Fruit characteristics of sweet watermelon are largely the result human selection. Here we report an improved reference genome and whole-genome resequencing 414 accessions representing all extant species in Citrullus genus. Population genomic analyses reveal evolutionary history Citrullus, suggesting independent evolutions amarus lineage containing lanatus mucosospermus. Our findings indicate that different loci affecting fruit size have been under selection during speciation, domestication...
Sweetpotato [Ipomoea batatas (L.) Lam.] is a globally important staple food crop, especially for sub-Saharan Africa. Agronomic improvement of sweetpotato has lagged behind other major crops due to lack genomic and genetic resources inherent challenges in breeding heterozygous, clonally propagated polyploid. Here, we report the genome sequences its two diploid relatives, I. trifida triloba, show that these high-quality assemblies are robust references hexaploid sweetpotato. Comparative...
Auxin regulates the expression of diverse genes that affect plant growth and development. This regulation requires AUXIN RESPONSE FACTORS (ARFs) bind to promoter regions these genes. ARF6 ARF8 in Arabidopsis thaliana are required promote inflorescence stem elongation late stages petal, stamen, gynoecium All seed plants studied thus far have orthologues as well microRNA miR167, which targets ARF8. Whether broadly conserved roles flower development is not known. To address this question,...
Domestication of fruit and vegetables resulted in a huge diversity shapes sizes the produce. Selections that took place over thousands years alleles increased weight altered shape for specific culinary uses provide wealth resources to study molecular bases this diversity. Tomato (Solanum lycopersicum) evolved from wild ancestor (S. pimpinellifolium) bearing small round edible fruit. Molecular genetic studies led identification two genes selected weight: FW2.2 encoding member Cell Number...
Shapes of edible plant organs vary dramatically among and within crop plants. To explain ultimately employ this variation towards improvement, we determined the genetic, molecular cellular bases fruit shape diversity in tomato. Through positional cloning, protein interaction studies, genome editing, report that OVATE Family Proteins TONNEAU1 Recruiting Motif proteins regulate cell division patterns ovary development to alter final shape. The physical interactions between members these two...
The Cucurbitaceae family (cucurbit) includes several economically important crops, such as melon, cucumber, watermelon, pumpkin, squash and gourds. During the past years, genomic genetic data have been rapidly accumulated for cucurbits. To store, mine, analyze, integrate disseminate these large-scale datasets to provide a central portal cucurbit research breeding community, we developed Cucurbit Genomics Database (CuGenDB; http://cucurbitgenomics.org) using Tripal toolkit. database currently...
Abstract The Cucurbitaceae (cucurbit) family consists of about 1,000 species in 95 genera, including many economically important and popular fruit vegetable crops. During the past several years, reference genomes have been generated for >20 cucurbit species, variome transcriptome profiling data rapidly accumulated cucurbits. To efficiently mine, analyze disseminate these large-scale datasets, we developed an updated version Cucurbit Genomics Database. database, CuGenDBv2...
Pepper (Capsicum spp.) is one of the earliest cultivated crops and includes five domesticated species, C. annuum var. annuum, chinense, frutescens, baccatum pendulum pubescens. Here, we report a pepper graph pan-genome genome variation map 500 accessions from Capsicum species close wild relatives. We identify highly differentiated genomic regions among peppers that underlie their natural variations in flowering time, characteristic flavors, unique resistances to biotic abiotic stresses....
The metabolic syndrome (MetS) epidemic is associated with economic development, lifestyle transition and dysbiosis of gut microbiota, but these associations are rarely studied at the population scale. Here, we utilised Guangdong Gut Microbiome Project (GGMP), largest Eastern population-based microbiome dataset covering individuals different statuses, to investigate relationships between host physiology, diet, geography, physical activity socioeconomic status. At level, 529 OTUs were...
Pomegranate (Punica granatum L.) has an ancient cultivation history and become emerging profitable fruit crop due to its attractive features such as the bright red appearance high abundance of medicinally valuable ellagitannin-based compounds in peel aril. However, limited genomic resources have restricted further elucidation genetics evolution these interesting traits. Here, we report a 274-Mb high-quality draft pomegranate genome sequence, which covers approximately 81.5% estimated 336-Mb...
One of the major genes controlling elongated fruit shape tomato (Solanum lycopersicum) is SUN. In this study, we explored roles SUN in vegetative and reproductive development using near isogenic lines (NILs) that differ at sun locus, overexpressors both wild species LA1589 pimpinellifolium) cultivar Sun1642 background. Our results demonstrate controls through redistribution mass mediated by increased cell division longitudinal decreased transverse direction fruit. The expression positively...
Solanum pimpinellifolium (SP) is the wild progenitor of cultivated tomato. Because its remarkable stress tolerance and intense flavor, SP has been used as an important germplasm donor in modern tomato breeding. Here, we present a high-quality chromosome-scale genome sequence LA2093. Genome comparison identifies more than 92,000 structural variants (SVs) between LA2093 cultivar, Heinz 1706. Genotyping these SVs ~600 representative accessions alleles under selection during domestication,...
Years of selection for desirable fruit quality traits in dessert watermelon (Citrullus lanatus) has resulted a narrow genetic base modern cultivars. Development novel genomic and resources offers great potential to expand diversity improve important watermelon. Here, we report high-quality genome sequence cultivar 'Charleston Gray', principal American watermelon, complement the existing reference from '97103', an East Asian cultivar. Comparative analyses between genomes Gray' '97103'...
Abstract Background Genome structural variations (SVs) have been associated with key traits in a wide range of agronomically important species; however, SV profiles peach and their functional impacts remain largely unexplored. Results Here, we present an integrated map 202,273 SVs from 336 genomes. A substantial number selected during domestication improvement, which together affect 2268 genes. Genome-wide association studies 26 agronomic using these identify candidate causal variants. 9-bp...
Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, mechanism by which salt triggers kidney damage poorly understood. Our study investigated how high (HS) intake early considering 'gut-kidney axis'. We fed mice 2% NaCl in drinking water continuously 8 weeks to induce injury. found that 'quantitative' and 'qualitative' levels intestinal microflora were significantly altered after chronic HS feeding, indicated occurrence enteric...
Bottle gourd (Lagenaria siceraria) is an important vegetable crop as well a rootstock for other cucurbit crops. In this study, we report high-quality 313.4-Mb genome sequence of bottle inbred line, USVL1VR-Ls, with scaffold N50 8.7 Mb and the longest 19.0 Mb. About 98.3% assembled scaffolds are anchored to 11 pseudomolecules. Our comparative genomic analysis identifies chromosome-level syntenic relationships between cucurbits, lineage-specific gene family expansions in gourd. We...
Abstract Pear is a major fruit tree crop distributed worldwide, yet its breeding very time-consuming process. To facilitate molecular and gene identification, here we have performed genome-wide association studies (GWAS) on eleven traits. We identify 37 loci associated with eight quality traits five three phenological Scans for selective sweeps indicate that including stone cell content, organic acid sugar contents might been under continuous selection during improvement. One candidate gene,...
Increasing evidences suggest that angiotensin (Ang) II participates in the pathogenesis of endothelial dysfunction (ED) through multiple signaling pathways, including type 1 receptor (AT1R) mediated NADPH oxidase (Nox)/reactive oxygen species (ROS) signal transduction. However, detailed mechanism is not completely understood. In this study, we reported AngII/AT1R-mediated activated protein phosphatase 2A (PP2A) downregulated nitric oxide synthase (eNOS) phosphorylation via Nox/ROS pathway....
Significance Wild progenitors of crops are important resources for breeding and understanding domestication, but identifying them is difficult. Using an integrative approach, we discovered that a Sudanese form melon with nonbitter whitish pulp, known as the Kordofan melon, closest relative domesticated watermelons possible progenitor. To gain insights into genetic changes occurred from progenitor to watermelon, assembled annotated genome at chromosome level. Our analyses imply early farmers...