A5100443000- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Advanced Radiotherapy Techniques
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Breast Cancer Treatment Studies
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related gene regulation
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Radiation Therapy and Dosimetry
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Molecular Biology Techniques and Applications
- Nuts composition and effects
- Genetic factors in colorectal cancer
- Advanced X-ray and CT Imaging
- Genomic variations and chromosomal abnormalities
Nanchang University
2020-2024
Aerospace Center Hospital
2024
Hangzhou First People's Hospital
2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2023
Wenzhou Medical University
2023
Second Affiliated Hospital of Nanchang University
2020-2023
Air Force Medical University
2018-2023
Peking University Shenzhen Hospital
2021-2023
Sidney Kimmel Comprehensive Cancer Center
2012-2023
Johns Hopkins University
2007-2023
Abstract Background Hypoxia, a typical hallmark of solid tumors, exhibits an essential role in the progression colorectal cancer (CRC), which dysregulation long non-coding RNAs (lncRNAs) is frequently observed. However, underlying mechanisms are not clearly defined. Methods The TCGA database was analyzed to identify differential lncRNA expression involved hypoxia-induced CRC progression. qRT-PCR conducted validate upregulation STEAP3-AS1 cell lines and tumor-bearing mouse zebrafish models...
Long non-coding RNA MEG3 has been identified as a tumor suppressor which plays important roles in tumorigenesis; however, its potential role breast cancer not fully examined. Here, we showed that was downregulated tissues and cell lines. Overexpression of inhibited proliferation invasion, suggesting played an progression metastasis. Moreover, upregulation caused marked inhibition angiogenesis-related factor expression. Conditioned medium derived from overexpressed cells significantly...
Abstract Development of the acquired resistance is one major obstacle during chemotherapy for cancer patients. Exosomes mediate intercellular communication and cause environmental changes in tumor progression by transmitting active molecules. In this study, role long noncoding RNA H19 within exosomes elucidated terms regulating doxorubicin (DOX) breast cancer. As a result, increased expression was observed DOX‐resistant cells comparison with corresponding parental cells. Suppression...
Mounting evidence suggests that long noncoding RNAs (lncRNAs) play important roles in the regulation of gene expression by acting as competing endogenous RNA (ceRNA). However, regulatory mechanisms lncRNA ceRNA gastric cancer (GC) are not fully understood. Here, we first constructed a dysregulated lncRNA-associated network integrating analysis profiles lncRNAs, microRNAs (miRNAs), and messenger (mRNAs). Then, determined three lncRNAs (RP5-1120P11, DLEU2, DDX11-AS1) hub which associated...
The effect of competing endogenous RNA (ceRNA) can regulate gene expression by competitively binding microRNAs. Fascin-1 (FSCN1) plays an important role in the regulation cellular migration and invasion during tumor progression, but how its regulatory mechanism works through ceRNA is still unclear bladder cancer (BLCA).The fascin-1, miR-200b, ZEB1-AS1 BLCA was investigated vitro vivo. interaction between identified using bioinformatics analysis, luciferase activity assays, RNA-binding...
BackgroundMost malignant brain gliomas (MBGs) are associated with dismal outcomes, mainly due to their late diagnosis. Current diagnostic methods for MBGs based on imaging and histological examination, which limits early detection. Here, we aimed identify reliable plasma lipid biomarkers non-invasive diagnosis MBGs.MethodsUntargeted lipidomic analysis was firstly performed using a discovery cohort (n=107). The data were processed by support vector machine (SVM)-based discriminating model...
Gastric cancer (GC) is a considerable global health burden. Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are aberrantly expressed in many cancers and play important roles GC. However, only few lncRNAs have been functionally characterized. In this study, we identified intergenic non-protein coding RNA 941 (LINC00941) potential biomarker for diagnosis prognosis from the genome atlas (TCGA), found expression of LINC00941 associated with tumor depth distant metastasis...
Abstract Classification of ovarian cancer by morphologic features has a limited effect on serous (SOC) treatment and prognosis. Here, we proposed new system for SOC subtyping based the molecular categories from Cancer Genome Atlas project. We analyzed DNA methylation, protein, microRNA gene expression 1203 samples 599 patients. These were divided into nine subtypes RNA-seq data each subtype was found to be associated with activation and/or suppression following four biological processes:...
There has been little investigation carried out into the activity of immune-related genes in prognosis non-small cell lung cancer (NSCLC). Our study set to analyze correlation between differential expression immune and NSCLC by screening genes. Based on identified, we aimed construct a prognostic risk model explore some novel molecules which have predictive potential for therapeutic effect cancer.Immune gene transcriptome data clinical samples were extracted from TCGA database, transcription...
Atherosclerosis (AS) is a chronic inflammatory disease with the formation and accumulation of macrophage-derived foam cells in subendothelial space blood vessels as one major characteristic. Insulin-like growth factor 2 messenger RNA (mRNA) binding protein 1 (IGF2BP1) an RNA-binding its elevation has been reported to be associated macrophage infiltration into atherosclerotic vascular wall. This study aims investigate roles IGF2BP1 AS-associated cell formation. Herein, ApoE-/- mice fed...
The transcription cofactor limb-bud and heart (LBH) is involved in embryonic development. However, its role human lung cancer, especially adenocarcinoma (LUAD), remains unclear.A public database tissue microarray (TMA) were used to compare differences LBH expression relationship with clinical characteristics. Tissue from an additional 70 LUAD patients follow-up records was explore the correlation of prognosis. Cellular molecular studies validated growth invasion.LBH significantly...
Accumulating research reports have indicated that long non-coding RNAs (lncRNAs) are abnormally expressed in many types of cancers. However, few lncRNA signatures for predicting cancer prognosis been established. Our goal is to establish a signature the clear cell renal carcinoma (ccRCC).We downloaded KIRC FPKM (Fragments Per Kilobase transcript per Million Fragments) standardized expression data from The Cancer Genome Atlas (TCGA) by using TANRIC tool. We established an 11-lncRNA was...
Background: Long noncoding RNA SNHG10 has been reported to promote the development of liver cancer. While by analyzing The Cancer Genome Atlas (TCGA) dataset we observed downregulation in non-small cell lung cancer (NSCLC). This study aimed investigate roles NSCLC. Materials and Methods: included 60 pairs NSCLC nontumor tissue samples collected from patients (males females, 39–66 years, 50.9 ± 5.5 years). Gene expression was detected quantitative polymerase chain reaction western blot....
The dysregulation of long non-coding RNAs (lncRNAs) and transcription factors (TFs) is closely related to the development progression drug resistance in cancer chemotherapy. However, their regulatory interactions multidrug (MDR) gastric (GC) has largely remained unknown. In this study, we report a novel oncogenic role lncRNA FENDRR conferring MDR GC by coordinated regulation FOXC2 expression at transcriptional posttranscriptional levels. vitro vivo experiments demonstrated that...
Abstract The pleiotropic effect of cancer‐associated fibroblasts (CAFs) on tumour progression depends the environment. circFARP1 is critical for CAFs‐induced gemcitabine (GEM) resistance in pancreatic cancer. Its specific role and mechanism non–small cell lung cancer (NSCLC) have not been reported yet. We prepared a fibroblasts‐conditioned medium (CAF‐CM) to incubate A549 cells. Quantitative real‐time polymerase chain reaction was used detect RNA levels. detected protein expression by...
Objective: To investigate the effect of long noncoding RNA GM16343 on interleukin 36β promotion CD8 + T cells in tumor microenvironment regulation. Methods: The differentially expressed 36β-stimulated mouse was screened by gene chip technology, and significant RNAs were verified real-time polymerase chain reaction. lentiviral vector that overexpresses or knockdown constructed, transfected into cells, stimulated with 36β, amount interferon γ secreted detected enzyme-linked immunosorbent...
Long non-coding RNA (lncRNA) participates in the regulation of various biological processes, but its function and characteristics intramuscular fat (IMF) deposition different breeds pigs have not been fully understood. IMF content is one important factors affecting pork quality. In present study, differentially expressed lncRNAs (DE lncRNAs) their target genes were screened by comparing Queshan Black (QS) Large White (LW) based on RNA-seq. The results displayed 55 DE between QS LW, 29...
Ovarian cancer (OC) is characterised by heterogeneity that complicates the prediction of patient survival and treatment outcomes. Here, we conducted analyses to predict prognosis patients from Genomic Data Commons database validated predictions fivefold cross-validation using an independent dataset in International Cancer Genome Consortium database. We analysed somatic DNA mutation, mRNA expression, methylation, microRNA expression data 1203 samples 599 serous ovarian (SOC) patients. found...
Nitrative and oxidative DNA damage plays an important role in inflammation-related carcinogenesis. To investigate the involvement of stem cells Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, ALDH1A1) NPC tissues lines. We also measured 8-nitroguanine formation as indicator lesions. The intensity was significantly higher inflammatory stroma than chronic...
Abstract Small nucleolar RNA host gene 12 (SNHG12) has been indicated in the tumorigenesis of various human cancers, including clear cell renal carcinoma (ccRCC). However, underlying mechanisms SNHG12 driving progression ccRCC remain incompletely understood. In present study, we discovered that is up‐regulated and overexpression predicted poor clinical outcome patients. knockdown notably inhibited proliferation migration RCC cells. Furthermore, miR‐30a‐3p, a putative inhibitor, was...