A5015377261- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lysosomal Storage Disorders Research
- Circular RNAs in diseases
- Trypanosoma species research and implications
- Retinal Diseases and Treatments
- Ferroptosis and cancer prognosis
- Glaucoma and retinal disorders
- Flavonoids in Medical Research
- Cellular transport and secretion
- Asthma and respiratory diseases
- Alcohol Consumption and Health Effects
- Garlic and Onion Studies
- Endometrial and Cervical Cancer Treatments
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- IgG4-Related and Inflammatory Diseases
- Allergic Rhinitis and Sensitization
- Zebrafish Biomedical Research Applications
- Prenatal Substance Exposure Effects
- Gout, Hyperuricemia, Uric Acid
- Birth, Development, and Health
- Alcoholism and Thiamine Deficiency
Chinese PLA General Hospital
2016-2024
Ningbo University
2023-2024
Xiangya Hospital Central South University
2021-2023
Central South University
2021-2023
Lesya Ukrainka Volyn National University
2021
China Medical University
2020-2021
Rutgers, The State University of New Jersey
2017-2021
Tianjin Medical University General Hospital
2021
Shanghai Ninth People's Hospital
2020
Shanghai Jiao Tong University
2020
Ovarian cancer (OC) ranks fifth as a cause of gynecological cancer-associated death globally. Until now, the molecular mechanisms underlying tumorigenesis and prognosis OC have not been fully understood. This study aims to identify hub genes therapeutic drugs involved in OC.Four gene expression profiles (GSE54388, GSE69428, GSE36668, GSE40595) were downloaded from Gene Expression Omnibus (GEO), differentially expressed (DEGs) tissues normal with an adjusted P-value < 0.05 |log fold change...
Diabetic retinopathy (DR) is one of the most common microvascular complications diabetes, which associated with damage blood-retinal barrier and ischemia retinal vasculature. It devastates visual acuity due to leakage vessels aberrant pathological angiogenesis in diabetic patients. The etiology DR complex, accumulated studies have shown that autophagy plays an important role pathogenesis DR, but its specific mechanism needs be further studied.This study chose online Gene Expression Omnibus...
Background Diabetic retinopathy is a diabetic microvascular complication. Pyroptosis, as way of inflammatory death, plays an important role in the occurrence and development retinopathy, but its underlying mechanism has not been fully elucidated. The purpose this study to identify potential pyroptosis-related genes by bioinformatics analysis validation model predict microRNAs (miRNAs) long non-coding RNAs (lncRNAs) interacting with them. Subsequently, competing endogenous RNA (ceRNA)...
Enzyme replacement therapy for Gaucher disease (GD) has been available since 1991. This study compared the efficacy and safety of velaglucerase alfa with imiglucerase, previous standard care. A 9-month, global, randomized, double-blind, non-inferiority imiglucerase (60 U/kg every other week) in treatment-naïve patients aged 3-73 years anemia either thrombocytopenia or organomegaly. The primary endpoint was difference between groups mean change from baseline to 9 months hemoglobin...
Abstract Classification of ovarian cancer by morphologic features has a limited effect on serous (SOC) treatment and prognosis. Here, we proposed new system for SOC subtyping based the molecular categories from Cancer Genome Atlas project. We analyzed DNA methylation, protein, microRNA gene expression 1203 samples 599 patients. These were divided into nine subtypes RNA-seq data each subtype was found to be associated with activation and/or suppression following four biological processes:...
Background Turner syndrome (TS) is a sex chromosome aneuploidy with variable spectrum of symptoms including short stature, ovarian failure and skeletal abnormalities. The etiology TS complex, the mechanisms driving its pathogenesis remain unclear. Methods In our study, we used online Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE46687 to identify differentially expressed genes (DEGs) between monosomy X patients normal female individuals. relevant data on 26...
Glaucoma is the leading cause of irreversible blindness worldwide. Emerged evidence has shown that glaucoma considered an immune system related disorder. The gut largest organ in human body and microbiota (GM) plays role maintaining homeostasis. But, how GM influences remains unrevealed. This study aimed at investigating key molecules/pathways mediating to provide new biomarkers for future predictive, preventive, personalized medicine.Datasets from primary open-angle (POAG) patients...
Single disease payment program based on clinical pathway (CP-based SDP) plays an increasingly important role in reducing health expenditure china and there is a clear need to explore the scheme from different perspectives. This study aimed at evaluating effect of rural county public hospitals within Anhui, typical province China,using uterine leiomyoma as example. The data were extracted platform New Rural Cooperative Medical Office Anhui Province using stratified-random sampling. Means,...
Ferroptosis, a type of cell death caused by phospholipid peroxidation, has lately been linked to the onset and development numerous illnesses. Numerous investigations have demonstrated close relationship between lipid peroxidation carotid atherosclerosis. In order get new knowledge for targeted therapy, bioinformatics analysis was employed in this study discover probable ferroptosis-related genes The GSE43292 gene expression dataset downloaded from Gene Expression Omnibus (GEO) database....
Lysosomes are membrane-bound, acidic eukaryotic cellular organelles that play important roles in the degradation of macromolecules. Mutations cause loss lysosomal protein function can lead to a group disorders categorized as storage diseases (LSDs). Suspicion LSD is frequently based on clinical and pathologic findings, but some cases, underlying genetic biochemical defects remain unknown. Here, we performed whole-exome sequencing (WES) 14 suspected cases evaluate feasibility using WES for...
Abstract Background Gene Regulatory Networks (GRNs) provide integrated views of gene interactions that control biological processes. Many public databases contain extracted from experimentally validated literature reports, but most furnish only information for a few genetic model organisms. In order to bioinformatic tool researchers who work with non-model organisms, we developed RefNetBuilder, new platform allows construction putative reference pathways or GRNs expressed sequence tags...
To investigate the clinical characteristics, coexisting gene mutations and prognosis of acute myeloid leukemia (AML) patients with
Onions (
it is necessary to find a method for non-invasive monitoring of Her-2 status. MRI with characteristics multi-direction, multi-parameter, multi-function, high soft-tissue resolution, and non-invasiveness, has become the preferred evaluation uterine lesions.
Abstract Background Qualitative research can reflect the actual thoughts and experience of subjects be used to explore experiences women presenting with twin-to-twin transfusion syndrome (TTTS) facilitate provision targeted psychological support. Methods A semi-structured interview method was assess pregnancy parenting TTTS. Colaizzi for data analysis. Results Eighteen participated in study. We found that TTTS during experienced persistent worry about their children’s health from disease...