A5076455280- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Sepsis Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- RNA modifications and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Abdominal Trauma and Injuries
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Renal function and acid-base balance
- Hepatocellular Carcinoma Treatment and Prognosis
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Chromosomal and Genetic Variations
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Molecular Biology Techniques and Applications
- Respiratory Support and Mechanisms
- Retinoids in leukemia and cellular processes
- Trauma and Emergency Care Studies
- Neutropenia and Cancer Infections
- COVID-19 diagnosis using AI
- Acute Kidney Injury Research
Chinese PLA General Hospital
2016-2025
Chinese People's Liberation Army
2023-2024
Shandong University
2024
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Xilinx (United States)
2023
Hainan General Hospital
2023
Creative Commons
2023
Beijing Forestry University
2020-2022
People's Liberation Army No. 150 Hospital
2019-2021
Summary Background Currently, the prevention and control of novel coronavirus disease (COVID-19) outside Hubei province in China, other countries have become more critically serious. We developed validated a diagnosis aid model without computed tomography (CT) images for early identification suspected COVID-19 pneumonia (S-COVID-19-P) on admission adult fever patients made available via an online triage calculator. Methods Patients admitted from Jan 14 to February 26, 2020 with...
Currently, the need to prevent and control spread of 2019 novel coronavirus disease (COVID-19) outside Hubei province in China internationally has become increasingly critical. We developed validated a diagnostic model that does not rely on computed tomography (CT) images aid early identification suspected COVID-19 pneumonia (S-COVID-19-P) patients admitted adult fever clinics made available via an online triage calculator.Patients from January 14 February 26, 2020 with epidemiological...
Populus has a wide ecogeographical range spanning the Northern Hemisphere, and interspecific hybrids are common. tomentosa Carr. is widely distributed cultivated in eastern region of Asia, where it plays multiple important roles forestry, agriculture, conservation, urban horticulture. Reference genomes available for several species, however, our goals were to produce very high quality de novo chromosome-level genome assembly P. that could serve as reference evolutionary ecological studies...
Older patients with acute myeloid leukemia (AML) respond poorly to standard induction therapy. DNA methyltransferases (DNMTs) and histone-deacetylases (HDACs) are key regulators of gene expression in cells have been investigated as important therapeutic targets. However, their effects remains unclear therapy for AML. Previously untreated AML aged 60 years over (N=40) were enrolled into this single arm, open-label, phase 2 study evaluate the clinical efficacy safety chidamide combined CAG...
This case report presents the diagnosis and treatment process of a rare gastric perforation caused by short hair, leading to formation foreign body granuloma in child. The patient was 3-year-old boy who admitted hospital with persistent abdominal pain fever for more than 20 days. Ultrasound CT revealed inflammatory encapsulation cavity. Laparoscopic open surgeries were performed, revealing full-thickness wall approximately 2 mm diameter on greater curvature side stomach, which contact...
Pneumonia is a lower respiratory tract infection that causes dramatic mortality worldwide. The present study aimed to investigate the pathogenesis of pneumonia and identify microRNA (miRNA) biomarkers as candidates for targeted therapy. RNA from peripheral blood plasma participants with (severe, n=9; non‑severe, n=9) controls (n=9) was isolated paired‑end sequencing performed on an Illumina HiSeq4000 system. Following processing raw reads, sequences were aligned against Genome Reference...
Objective To summarize the clinical and pathological features of patients with cardiac lymphoma. Methods The general conditions, features, types, prognostic indices 37 lymphoma treated in our hospital were analyzed. Results Among patients, only one had primary lymphoma, other 36 secondary manifestations mainly chest tightness, shortness breath, increased heart rates, electrocardiographic abnormality caused by pericardial effusion, but myocardial enzyme levels normal all patients. Only three...
Abstract DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that promoter signature + AML blasts differs from − AMLs. This study demonstrated a novel hypermethylated zinc finger‐containing protein, THAP10, target and can be epigenetically suppressed AML1‐ETO at transcriptional level AML. Our findings also show THAP10 bona fide miR‐383...
BACKGROUND:This study aimed to identify the potential key long non-coding RNAs (lncRNAs) and target genes associated with pneumonia using lncRNA sequencing (lncRNA-seq). MATERIAL AND METHODS:A total of 9 peripheral blood samples from patients mild (n=3) severe (n=3), as well volunteers without were received for lncRNA-seq. Based on data, differentially expressed lncRNAs (DE-lncRNAs) identified by limma package. After functional enrichment analysis, DE-lncRNAs predicted, regulatory network...
The prognostic significance of loss X chromosome (-X) in t(8;21) acute myeloid leukemia (AML) remains unclear. We evaluated the role -X 158 female patients with AML collected retrospectively from 15 Chinese study groups. Patients accounted for 25.3% and showed a significantly higher complete remission rate, better 3-year cumulative incidence relapse (25.2 vs. 50.5%, p = 0.013), relapse-free survival (69.4 44.7%, 0.025), overall (77.4 52.7%, 0.026) compared those without -X. were more likely...
Background: Ruxolitinib is newly approved for glucocorticoid-refractory acute graft-versus-host disease (GVHD) in patients undergoing allo-geneic hematopoietic stem-cell transplantation (allo-HSCT), and voriconazole commonly used allo-HSCT recipients the prophylaxis or treatment of invasive fungal infections (IFIs). Drug–drug interaction (DDI) may occur between them because their metabolic pathways overlap can be inhibited by voriconazole, including cytochrome P450 (CYP) isozymes 3A4 2C9....
The prognostic significance of loss the Y chromosome (LOY) in patients with t(8;21)(q22;q22) acute myeloid leukemia (AML) remains poorly understood. To investigate this issue, 226 younger adult male t(8;21) AML from 15 Chinese hematology research centers were retrospectively evaluated, among which, 50.4% had LOY. In receiving high-dose cytarabine (HiDAC) consolidation therapy, LOY was associated a significantly higher cumulative incidence relapse (CIR, HR = 2.18, p .048), worse relapse-free...
The t(8;21)(q22;q22) translocation is the most common chromosomal in acute myeloid leukemia (AML), and it gives rise to gene 1 (AML1)-myeloid transforming 8 (ETO)-positive AML, which has a relatively favorable prognosis. However, molecular mechanism related prognosis AML1-ETO-positive AML still not fully understood. Our results show that AML1-ETO fusion protein triggered activation of early growth response l (EGR1) by binding at AML1-binding sites on EGR1 promoter and, subsequently,...
BACKGROUND:The overall prognosis of acute myeloid leukemia (AML) patients with mixed-lineage (MLL) gene-positivity is unfavorable. In this study, we evaluated the expression levels MLL gene in AML patients. MATERIAL AND METHODS:We enrolled 68 gene-positive out 433 newly diagnosed patients, and 216 bone marrow samples were collected. Real-time fluorescence quantitative PCR (RQ-PCR) was used to precisely detect gene. RESULTS:We divided 41 into 2 groups according variation MRD (minimal residual...
BACKGROUND:Acute myeloid leukemia (AML) patients with mixed lineage (MLL) gene rearrangements always had a very poor prognosis. In this study, we report the incidence of MLL in AML using analysis, as well clinical significance and prognostic features these rearrangements. MATERIAL AND METHODS:This retrospective study took place from April 2008 to November 2011 People’s Liberation Army General Hospital. A total 433 were screened by multiple nested reverse transcription polymerase chain...
RT-qPCR is considered a rapid and reliable technique for analyzing gene expression. This commonly used to analyze the expression of various genes at diverse transcriptional levels in different samples. However, few studies have characterized ornamental Koelreuteria species reference genes. In this study, eight were evaluated as controls with SYBR green quantify paniculata All selected showed broad range Ct values all samples, which was supportive their variable Our results significant...
Background: Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) is a novel regulator of histone H3 acetylation and promotes leukemogenesis in acute myeloid leukemia (AML). However, its prognostic value AML remains unclear. Methods: In this study, we evaluated the significance ANP32A expression using two independent large cohorts cytogenetically normal (CN-AML) patients. Multivariable analysis CN-AML group was also presented. Based on expression, related genes, dysregulation pathways,...
Flowering is an important link in the life process of angiosperms, and it also sign transformation plants from vegetative to reproductive growth. Although flowering regulation network Arabidopsis well-understood, there has been little research on molecular mechanisms perennial woody plant flower development regulation. Populus tomentosa a unique Chinese poplar species with fast growth, strong ecological adaptability, long lifecycle. However, juvenile phase, which seriously affects its...
This study aimed to identify the potential key genes associated with severe pneumonia using mRNA-seq. Nine peripheral blood samples from patients alone (SP group, n=3) and accompanied chronic obstructive pulmonary disease (COPD; CSP n=3), as well volunteers without (control underwent Based on sequencing data, differentially expressed (DEGs) were identified by Limma package. Following pathway enrichment analysis of DEGs, that in SP groups selected for coexpression analysis. In addition,...