A5101881232- Antibiotics Pharmacokinetics and Efficacy
- Thyroid Cancer Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Thyroid and Parathyroid Surgery
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Vascular Malformations Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Ferroptosis and cancer prognosis
- Cancer therapeutics and mechanisms
- Ultrasound and Hyperthermia Applications
- Vascular Malformations and Hemangiomas
- Cardiac electrophysiology and arrhythmias
- Voice and Speech Disorders
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Plant-based Medicinal Research
- Multiple Myeloma Research and Treatments
- Advanced Electron Microscopy Techniques and Applications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intramuscular injections and effects
- Cystic Fibrosis Research Advances
- Traditional Chinese Medicine Analysis
- Parathyroid Disorders and Treatments
Anhui Medical University
2025
Nantong University
2025
Affiliated Hospital of Nantong University
2025
Beijing Jishuitan Hospital
2022-2024
Peking University
2022-2024
Chinese PLA General Hospital
2009-2023
John Wiley & Sons (United States)
2022
Hudson Institute
2022
Chinese People's Liberation Army
2009-2021
Linyi People's Hospital
2014
Background Microwave ablation (MWA) has achieved favorable results in the treatment of papillary thyroid microcarcinoma (PTMC) confined glandular parenchyma. However, studies on outcome MWA for PTMC with US-detected capsular invasion remain unclarified literature. Purpose To compare feasibility, effectiveness, and safety without invasion. Materials Methods Participants from 12 hospitals a maximal diameter 1 cm or less US- CT-detected lymph node metastasis (LNM) who planned to undergo were...
ABSTRACT MIC- and mutant prevention concentration (MPC)-based pharmacokinetic/pharmacodynamic (PK/PD) indices were compared for suitability as attainment targets restricting amplification of levofloxacin-resistant subpopulations. When three Staphylococcus aureus strains examined with a hollow-fiber PK/PD model, area under the concentration-time curve over 24 h (AUC )/MPC values >25 maximum drug in serum ( C max >2.2 predicted resistance outcome among different isolates an interisolate...
Background: Ruxolitinib is newly approved for glucocorticoid-refractory acute graft-versus-host disease (GVHD) in patients undergoing allo-geneic hematopoietic stem-cell transplantation (allo-HSCT), and voriconazole commonly used allo-HSCT recipients the prophylaxis or treatment of invasive fungal infections (IFIs). Drug–drug interaction (DDI) may occur between them because their metabolic pathways overlap can be inhibited by voriconazole, including cytochrome P450 (CYP) isozymes 3A4 2C9....
What is known and objective In China, lidocaine together with 2 mg/mL of pingyangmycin (PYM, also as bleomycin A5) recommended for the treatment venous malformations (VMs). The purpose this study was to investigate whether has a synergistic effect PYM in improving therapeutic outcomes patients VMs. Additionally, aimed evaluate sclerotherapy VMs using an intralesional injection low concentration (0·5 mg/mL). Methods A total 281 were treated 0·5 or without dexamethasone (DEX). All received...
A rapid, sensitive and specific analytical method based on high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed for the determination of thalidomide concentration in human plasma. The analyte internal standard were extracted by liquid-liquid extraction with ether-dichloromethane (3:2, v/v) separated a TC-C(18) column using methanol-10 mM ammonium acetate-formic acid (60:40:0.04, v/v/v) as mobile phase at flow rate 0.9 ml/min. detection was performed...
This study assessed the safety, tolerability, and PK/PD of HSK7653 tablets in Chinese patients with type 2 diabetes mellitus (T2DM). was a Phase IIa, multicenter, randomized, double-blind, placebo-controlled, dose-increasing 48 patients. Subjects were randomly assigned to placebo 10/25/50 mg dose groups, they received oral administration once every two weeks for total six times. Safety tolerability throughout this study, parameters analyzed using non-compartment model WinNonlin. The three...
Objectives: The objective was to evaluate the pharmacokinetic and pharmacodynamic properties of a single intravenous fixed dose compared with weight-adjusted linezolid. Methods: A Phase I, comparative clinical trial conducted involving 20 healthy male Chinese volunteers, assigned into low weight (LW) (50 kg < ≤ 55 kg) high (HW) (≥ 80 groups. All subjects were administrated linezolid (600 mg/30 min) and, after 72 h washout period, another single-dose (10 mg/kg/30 min). Plasma concentrations...
We determined the concentration-time profiles of ciprofloxacin and amikacin in serum alveolar epithelial lining fluid (ELF) rats with or without pulmonary fibrosis investigated effect on capacity for penetration antimicrobials into ELF rats. Pulmonary was induced a single intratracheal instillation bleomycin. After intravenous injection amikacin, blood bronchoalveolar lavage samples were collected. Urea concentrations using an enzymatic assay. Ciprofloxacin by high-performance liquid...
To develop and verify a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for determining contezolid in plasma cerebrospinal fluid (CSF). Protein precipitation was performed on samples using linezolid as the internal standard. We used an Agilent EclipsePlus C18 column operating at 0.4 mL/min conjunction with acetonitrile water mobile phases LC-MS/MS analysis. Using precursor-product ion pairs 409.15→269.14 (contezolid) 338.14→195.1 (linezolid), multiple reaction monitoring to...
ABSTRACT A sensitive, specific and simple LC‐MS/MS method was developed for the identification quantification of bivalirudin in human plasma using diazepam as an internal standard (IS). The API‐4000 operated under multiple‐reaction monitoring mode electrospray ionization. sample preparation consisted easy protein precipitation pretreatment with methanol. Chromatographic separation achieved on a Zorbax Eclipse plus C 18 100 × 2.1 mm column mobile phase water–methanol–0.1% formic acid....
The Chinese Guidelines for Ultrasound-guided Thermal Ablation of Thyroid Nodules (2024 edition) were jointly initiated by the Ultrasound Committee Medical Association, Interventional Association in Medicine and Engineering, Ultrasonic Intervention Colleges Interventionalists, Oncological Research Hospital 37 multidisciplinary experts interventional ultrasound, ultrasound medicine, endocrinology thyroid surgery participated compilation this guide, which expanded depth breadth perspective...
A simple and accurate method for the determination of voriconazole concentrations in human CSF was developed validated, which can be used drug monitoring treatment central nervous system infections.