A5024723836- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Thyroid Cancer Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Thyroid and Parathyroid Surgery
- Nanoparticle-Based Drug Delivery
- Ultrasound and Hyperthermia Applications
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Renal cell carcinoma treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Atmospheric chemistry and aerosols
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Air Quality Monitoring and Forecasting
- Multiple and Secondary Primary Cancers
- MRI in cancer diagnosis
- Hepatitis C virus research
- Inflammasome and immune disorders
- Gallbladder and Bile Duct Disorders
- Cancer and Skin Lesions
- Liver physiology and pathology
Chinese PLA General Hospital
2016-2025
People's Liberation Army No. 150 Hospital
2017-2024
Chinese People's Liberation Army
2017-2024
Dalian Medical University
2024
First Affiliated Hospital of Zhengzhou University
2024
First Affiliated Hospital of Dalian Medical University
2024
State Council of the People's Republic of China
2021
Guangzhou University of Chinese Medicine
2020
Central Hospital of Zibo
2019
Air Force Medical University
2014
Combining photothermal therapy (PTT) with clinical technology to kill cancer via overcoming the low tumor targeting and poor efficiency has great potential in basic researches. A brand‐new MoS 2 nanostructure is designed fabricated, i.e., layered hollow spheres (LMHSs) strong absorption near‐infrared region (NIR) high conversion a simple fast chemical aerosol flow method. Owing curving spherical structure, as‐prepared LMHSs exhibit unique electronic properties comparing nanosheets. In vitro...
Microwave (MW) therapy, as a promising type of thermal has been attracting more and attention from scientists. The combination chemotherapy is great significance in the latest studies synergistic tumor therapy. However, research on MW therapy mechanism, especially nonthermal effect applied combined cancer not thorough enough. Pleasantly, we have discovered that irradiation can promote cellular uptake nanoparticles anticancer drugs via experiments vitro vivo. Therefore, multifunctional...
The diagnosis performance of B-mode ultrasound (US) for focal liver lesions (FLLs) is relatively limited. We aimed to develop a deep convolutional neural network US (DCNN-US) aiding radiologists in classification malignant from benign FLLs.This study was conducted 13 hospitals and finally 2143 patients with 24,343 images were enrolled. Patients who had non-cystic FLLs pathological results 11 randomly divided into training internal validations (IV) cohorts 4:1 ratio developing evaluating...
Hepatocellular carcinoma (HCC) with metastatic disease is associated a low survival in clinical practice. Many curative options including liver resection, transplantation, and thermal ablation are effective local but limited for patients distant metastasis. In this study, the efficacy, specificity, safety of P-selectin targeted delivery microwave (MW) responsive drug release investigated development HCC therapy. By encapsulating doxorubicin (DOX) MW sensitizer...
Hepatocellular carcinoma recurrence and metastasis after microwave ablation (MWA) are challenges in the clinic. This study showed that mannose-derived carbon dots (Man-CDs) could effectively capture several "danger signals" (DS) MWA treatment then deliver DS specifically to dendritic cells (DCs). improved delivery of DCs enhanced processing presentation tumor-associated antigens by DCs. The results demonstrated intratumoral injection Man-CDs therapy elicited a potent tumor-specific immune...
Ionic liquid (IL)-loaded or metal ions-enriched nanoparticles have been witnessed to assist microwave ablation (MWA) and heighten heat utilization for tumor treatment, which, however, inevitably brings about cell dys-homeostasis severely endangers normal cells tissues. In this report, a nonionic MWA sensitizer that encapsulates ethyl formate (EF) doxorubicin (DOX) in liposomes (EF-DOX-Lips) was constructed reinforce combined therapy against incomplete MWA-induced recurrence. EF EF-DOX-Lips...
Abstract During the onset of liver fibrosis, capillarized sinusoidal endothelial cells (LSECs) limit substance exchange between blood and Disse space, further accelerating hepatic stellate cell (HSCs) activation fibrosis progression. Limited accessibility therapeutics to space is often overlooked remains a major bottleneck for HSCs‐targeted therapy in fibrosis. Here, an integrated systemic strategy treatment reported, utilizing pretreatment with soluble guanylate cyclase stimulator,...
BackgroundAblation has been recommended by worldwide guidelines as first-line treatment for hepatocellular carcinoma (HCC), while evidence regarding its efficacy primary intrahepatic cholangiocarcinoma (iCCA) is lacking. We aimed to study the of ablation in treating iCCA comparing prognosis with surgery.MethodsIn this real-world multicenter cohort from January 2009 June 2022, 10,441 patients ten tertiary hospitals were identified. Patients who underwent curative-intent microwave (MWA) or...
Abstract Objectives Wedelolactone exhibits regulatory effects on some inflammatory diseases. However, the anti‐inflammatory mechanism of wedelolactone has not been entirely unravelled. Therefore, present study focuses investigating NLRP3 inflammasome in macrophages and its influence MSU‐induced inflammation. Materials Methods BMDM, J774A.1 PMA‐differentiated THP‐1 were primed with LPS then stimulated ATP or nigericin MSU crystal presence absence wedelolactone. The cell lysates supernatants...
Background Microwave ablation (MWA) has achieved favorable results in the treatment of papillary thyroid microcarcinoma (PTMC) confined glandular parenchyma. However, studies on outcome MWA for PTMC with US-detected capsular invasion remain unclarified literature. Purpose To compare feasibility, effectiveness, and safety without invasion. Materials Methods Participants from 12 hospitals a maximal diameter 1 cm or less US- CT-detected lymph node metastasis (LNM) who planned to undergo were...
Microwave (MW) hyperthermia has received great attention as an emerging green tumor thermotherapy. In this work, layered MoS2 nanoflowers were prepared through a simple bottom-up hydrothermal process. By coating with bovine serum albumin (BSA-MoS2), BSA-MoS2 exhibits low biotoxicity and excellent microwave susceptive properties in vitro. Meanwhile, the heating effect improvement by structure was confirmed via computer-simulated experiment. Finally, are designed MW susceptible agents for vivo...
Purpose: To compare the clinical efficacy of ultrasound-guided percutaneous microwave ablation (MWA) and parathyroidectomy for primary hyperparathyroidism. Methods: In an observational retrospective study, we compared outcomes in patients with hyperparathyroidism who underwent MWA those surgical resection (SR). The outcome was cure rate. Secondary were rate complications, difference treatment parameters two methods. Propensity-score matching used to assemble a cohort similar baseline...
Despite being a common therapy for hepatocellular carcinoma (HCC), insufficient thermal ablation can leave behind tumor residues that cause recurrence. This is believed to augment M2 inflammatory macrophages usually play pro-tumorigenic role. To address this problem, we designed d-mannose-chelated iron oxide nanoparticles (man-IONPs) polarize M2-like into the antitumor M1 phenotype. In vitro and in vivo experiments demonstrated man-IONPs specifically targeted accumulated peri-ablation zones...
Abstract. In this study, we developed an approach that integrated multiple patterns of timescale for box modeling (MCMv3.3.1) to better understand the O3–precursor relationship at sites and through continuous observations. A 5-month field campaign was conducted in summer 2019 investigate ozone formation chemistry three a major prefecture-level city (Zibo) Shandong Province northern China. It found relative incremental reactivity (RIR) precursor groups (e.g., anthropogenic volatile organic...
There is currently a lack of convincing evidence for microwave ablation (MWA) and laparoscopic liver resection (LLR) patients ≥60 years old with 3-5 cm hepatocellular carcinoma. Patients were divided into three cohorts based on restricted cubic spline analysis: 60-64, 65-72, ≥73 years. Propensity score matching (PSM) was performed to balance the baseline variables in 1:1 ratio. Overall survival (OS) disease-free (DFS) assessed, followed by comparison complications, hospitalization, cost....
Clinical trials have demonstrated that Trametes robinophila Murr (Huaier granule) can inhibit recurrence and metastasis after hepatocellular carcinoma (HCC) resection, but its efficacy as an adjuvant therapy thermal ablation of early HCC is unknown.To analyze the prognostic value side effects Huaier granules in patients undergoing ablation.Clinical information from 340 eligible subjects with early-stage who were admitted to our department September 1, 2008 January 2019 was extracted...
ObjectiveTo develop a prognostic model for optimizing management of colorectal liver oligometastases (CLOM) patients with different primary tumor locations who underwent thermal ablation (TA).Materials and MethodsThe reporting this retrospective study conforms to STROBE guidelines. A total 525 CLOM TA from 3 hospitals between 2011 2021 were enrolled. Firstly, intra extrahepatic disease-free survival (DFS) overall (OS) analyzed. Then, cox regression models used identify independent factors...