A5103117072- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Thyroid Disorders and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Erythrocyte Function and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Medical Imaging Techniques and Applications
- Melanoma and MAPK Pathways
- Inflammatory Bowel Disease
- Histone Deacetylase Inhibitors Research
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related Molecular Pathways
- Cytokine Signaling Pathways and Interactions
- Cancer and Skin Lesions
- Inflammasome and immune disorders
- Cancer-related gene regulation
- Pain Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Vitamin D Research Studies
First Affiliated Hospital of Xi'an Jiaotong University
2016-2023
Fourth Affiliated Hospital of China Medical University
2008-2022
China Medical University
2008-2022
Academy of Military Medical Sciences
2017
Guangxi Medical University
2017
First Affiliated Hospital of Zhengzhou University
2017
Lanzhou Army General Hospital
2013-2014
BRAFV600E, the most common genetic alteration, has become a major therapeutic target in thyroid cancer. Vemurafenib (PLX4032), specific inhibitor of BRAFV600E kinase, exhibits antitumor activity patients with BRAFV600E-mutated However, clinical benefit PLX4032 is often limited by short-term response and acquired resistance via heterogeneous feedback mechanisms. Disulfiram (DSF), an alcohol-aversion drug, shows potent efficacy copper (Cu)-dependent way. its cancer effect on cellular to BRAF...
// Chenxing Da 1, 2, * , Kexia Wu Chenli Yue 2 Peisong Bai 1 Rong Wang Guanjie Man Zhao Yanyan Lv Peng Hou 3 Department of Endocrinology, The First Affiliated Hospital Xi’an Jiaotong University, 710061, P.R. China Shanxi Provincial Crops Chinese People’s Armed Police Force, 710054, Key Laboratory for Tumor Precision Medicine Shaanxi Province, These authors have contributed equally to this work Correspondence to: Hou, email: phou@xjtu.edu.cn Keywords: thyroid cancer, N-cadherin,...
The role of circ_0089153 in breast cancer (BCa) malignancy development was explored. expression BCa analyzed by Gene Expression Omnibus database. Clinical tissues were obtained from 90 patients. Cell counting kit-8 assay, 5-ethnyl-2 deoxyuridine assay and colony formation experiment applied for proliferation detection. Wound healing Transwell used migration invasion Dual luciferase reporter gene RNA immunoprecipitation pull-down conducted. In vivo growth metastasis cells performed....
Abstract Accumulating evidence supports evolutionary trait of drug resistance. Like resilience in other systems, most tumor cells experience drug-tolerant state before full resistance acquired. However, the underlying mechanism is still poorly understood. Here, we identify that EGF like domain multiple 7 ( EGFL7 ) a responsive gene to epidermal growth factor receptor (EGFR) kinase inhibition during period when tumors are decimated. Moreover, our data reveal adaptive increase this process...
Previous studies disclosed that a high thyroid stimulating hormone level is an independent risk factor for diabetes peripheral neuropathy (DPN) in subclinical hypothyroidism (SCH) patients with type 2 mellitus (T2DM). However, whether metabolism has effect on DPN euthyroid T2DM remains unknown. The aim of this study was to identify the association between function and patients. A set 580 enrolled current stratified into Non-DPN groups. Mann-Whitney U test performed analyze continuous...
Context: There are few reports of endothelial progenitor cells (EPCs) in peripheral blood have been found patients with gastric cancer.Objective: We quantified EPCs the cancer, expectation that this approach might lead to a new marker for diagnosis cancer.Methods: enumerated CD34+/CD133+ 145 subjects by use flow cytometry.Results and conclusion: The quantity cancer correlated patient's age. In addition, number increased tumor node metastasis stage histological differentiation cancers,...
It is accepted that endothelial progenitor cells (EPCs) are recruited into tumor sites and take part in the neovascularization of tumors. However, few articles have discussed specific distribution EPCs vivo tissues gastric cancer patients. For this reason, present study sought to elucidate EPC patients with cancer. Fresh were collected from 26 newly diagnosed histologically confirmed (mean age, 51 years; range, 21-81 7 females, 19 males). All treated surgically curative intent. One portion...
Background Drug repurposing is an attractive strategy for extending the arsenal of oncology therapies. Tolperisone old centrally acting muscle relaxant used treatment chronic pain conditions. In this study, we investigated therapeutic effect and mechanism tolperisone in human cancers explored combination with proteasome inhibitor immunotherapy.
To investigate the effect of thrombocytopenia on migration patterns adoptive dendritic cell(DC) in vivo.The mouse model was established by intraperitoneal administration anti-CD41 mAb MWReg30. Mouse bone marrow(BM)-derived DC were injected into footpad infusion and intravenous infusion. The distribution pattern detected bioluminescence imaging.More than 80% platelets cleared experimental group which infused with antibody. At 72 h after injection, percentage that migrated from to popliteal...
Objective To evaluate the clinical value of fiberoptic ductoscopy in diagnosis and treatment patients with galactophoritis or mammary duct ectasia. Methods From November 2005 to March 2008, were performed 120 women nipple discharge. The 95 cases as non-malignant lesion insufflated perfusioned entamycin dexamethasone. Results Ninty-five disease,which contained one side 81 two sides 14; discharge was bloody,ivory, stramineous 21, 17, 57 patinents, respectively; dignosis 17 ectasia, 53...
Abstract Background Recent studies suggest that higher concentrations of free triiodothyronine (FT3) were associated with a lower prevalence microangiopathy in adult euthyroid people type 1 diabetes. This study was performed to identify the association between thyroid hormones and extremity arterial disease (LEAD) patients 2 diabetes mellitus (T2DM). Methods 1052 T2DM normal function enrolled, including 704 LEAD as observation group 348 alone control group. The differences basic data,...