A5014667245- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Spine and Intervertebral Disc Pathology
- interferon and immune responses
- Healthcare and Venom Research
- Contact Dermatitis and Allergies
- Pediatric health and respiratory diseases
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Drug-Induced Adverse Reactions
- Musculoskeletal pain and rehabilitation
- Respiratory and Cough-Related Research
- Insect and Pesticide Research
- Yersinia bacterium, plague, ectoparasites research
- Sinusitis and nasal conditions
- Cervical and Thoracic Myelopathy
- Bee Products Chemical Analysis
- Eosinophilic Esophagitis
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- NF-κB Signaling Pathways
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Clinical Research Center for Digestive Diseases
2021-2025
Harbin Institute of Technology
2025
Inner Mongolia Electric Power (China)
2023-2024
Xian Yang Central Hospital
2021-2024
Chinese PLA General Hospital
2019-2021
Academy of Medical Sciences
2021
Yulin Orthopedics Hospital of Chinese and Western Medicine
2020
Chinese People's Liberation Army
2013-2018
Previous studies have shown that both hepatitis A virus and C inhibit innate immunity by cleaving the mitochondrial antiviral signaling (MAVS) protein, an essential component of virus-activated pathway activates NF-kappaB IFN regulatory factor-3 to induce production type I IFN. For human B (HBV), s-Ag, e-Ag, or HBV virions been suppress TLR-induced activity with reduced IFN-beta subsequent induction IFN-stimulated genes. However, HBV-mediated suppression RIG-I-MDA5 is unknown. In this study,...
Stringent control of inflammasome signaling pathway is important for maintaining immunological balance, yet the molecular mechanisms responsible its tight regulation are still poorly understood. In this study, we found that dependent on mitochondrial antiviral protein (MAVS) was required optimal activation apoptosis-associated specklike (ASC)-dependent inflammasome. particular, TNFR-associated factor 3 to be a direct E3 ligase ASC. Ubiquitination ASC at Lys(174) critical speck formation and...
ABSTRACT Retinoic acid-inducible gene I (RIG-I) is an intracellular RNA virus sensor that induces type interferon-mediated host-protective innate immunity against viral infection. Although cylindromatosis (CYLD) has been shown to negatively regulate antiviral response by removing K-63-linked polyubiquitin from RIG-I, the regulation of its expression and underlying regulatory mechanisms are still incompletely understood. Here we show RIG-I activity regulated inhibition CYLD mediated microRNA...
Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge anaphylaxis risks related to different mAbs is essential their appropriate and safe administration. This study aimed evaluate associations between anaphylactic reactions by applying statistical approaches pharmacovigilance data.This was a retrospective using data from US Food Drug Administration Adverse Event Reporting System database January 2004 September...
A new mineralized collagen matrix combined with or without growth factor was used for the posterolateral spinal fusion in rabbit lumbar spine.The availability of a osteoconductive recombinant osteoinductive factors offers possible alternative to use autogenous bone grafting indications. This study evaluated bone-forming activity biomimetic matrix: nano-hydroxyapatite/collagen/polylactic acid (nHAC/PLA) human morphogenetic protein-2 (rhBMP-2) fusion.Many materials such as titanium alloy,...
The mitochondrial antiviral signaling protein MAVS (IPS-1, VISA, or Cardif) plays an important role in the host defense against viral infection by inducing type I interferon. Recent reports have shown that is also critical for virus-induced apoptosis. However, mechanism of MAVS-mediated apoptosis induction remains unclear. Here, we show binds to voltage-dependent anion channel 1 (VDAC1) and induces caspase-3 activation, which independent its innate immunity. modulates VDAC1 stability...
Significance We investigated the possible role of TANK-binding kinase 1 (TBK1) protein in tamoxifen resistance and found that phosphorylation by TBK1 at Ser-305 site stabilized estrogen receptor α (ERα) modulated its transcriptional activity. Ectopic expression rendered breast cancer cells resistant to tamoxifen. inhibition sensitized tamoxifen-induced cell death. The was increased subjects with positively correlated ERα, ERα Ser-305, cyclin D1 expression. Subjects tumors highly expressed...
Eosinophilic gastroenteritis (EGE) is a gastrointestinal disorder of unclear etiology that characterized by eosinophilic infiltration the stomach and small intestine, consists mucosal, muscular, serosal subtypes. tract fundamental histopathological characteristic EGE driven several T-helper type 2 (Th2)-dependent cytokines induced food allergy. Due to lack diagnostic gold standard, has high rate delayed diagnosis or misdiagnosis. However, new strategies have been developed, such as novel...
Abstract IFN regulatory factors play a pivotal role in many cellular processes, including inflammatory and immune responses. Their activation is tightly regulated by TANK-binding kinase 1 (TBK1). In response to microbial components, TBK1 activates factor 3 (IRF3) cytokine expression. this article, we show that novel target of the IpaH4.5 protein, Shigella type III effector possessing E3 ubiquitin ligase activity. Remarkably, interacts with promotes its K48-linked polyubiquitylation....
Metallic biomaterials are increasingly being used in various medical applications due to their high strength, fracture resistance, good electrical conductivity, and biocompatibility. However, practical have been largely limited poor surface performance. Laser microprocessing is an advanced method of enhancing the surface-related properties biomaterials. This work demonstrates capability laser for biomedical metallic materials including magnesium titanium alloys, with potential cell adhesion...
Abstract Background Hereditary angioedema is a rare autosomal dominant disease, and its correlation between genotype phenotype seems not to exist. So far, there are very few studies on C hinese population. We aimed establish genetic database of hereditary investigated the potential phenotype. Method All eight exons intron–exon boundaries 1 inhibitor gene were detected in 48 unrelated families with HAE . The correlations clinical parameters evaluated by R statistical software. Results...
There have been few studies comparing the clinical and radiographic outcomes between Dynesys dynamic stabilization system posterior lumbar interbody fusion (PLIF). The objective of this study is to compare PLIF for degenerative disease.Of 96 patients with disease included in retrospectively analysis, 46 were treated 50 underwent from July 2008 March 2011. Clinical evaluated. We also evaluated occurrence symptomatic adjacent segment degeneration (ASD).The mean follow-up time group was 53.6 ±...
Bone drilling has been widely used in medical surgeries such as repair and fixation orthopedics. Traditional method using drill-bits inevitably causes significant thermal mechanical trauma the adjacent bone tissues. This paper demonstrates feasibility of femtosecond laser vitro large-size holes on sheepshank with high efficiency minimal collateral damage. A Yb:KGW was utilized to drill millimeter-scale under different cooling conditions including gas- water-assisted processes. Scanning...
Data on allergic reactions after the administration of coronavirus disease (COVID-19) vaccines are limited. Our aim is to analyze reports COVID-19 vaccine administration.The Vaccine Adverse Event Reporting System database was searched for reported any from December 2020 June 2021. After data mapping, demographic and clinical characteristics cases were analyzed. Potential factors associated with anaphylaxis evaluated using multivariable logistic regression models.In total, 14,611 reported....
Hereditary angioedema (HAE), caused by C1 inhibitor deficiency, is characterized recurrent subcutaneous or submucosal swelling. Because it rare, data on clinical features, especially in Chinese patients, are not comprehensive. Our aim was to identify the characteristics of HAE a population and enhance knowledge this disease. One hundred fifty-eight symptomatic patients were studied retrospectively. Data obtained from medical records. Statistical analyses performed using statistical software...
Yersinia pestis uses type III effector proteins to target eukaryotic signaling systems. The outer protein (Yop) M from the Y. strain is a critical virulence determinant; however, its role in pathogenesis just beginning emerge. Here we first identify YopM as structural mimic of bacterial IpaH E3 ligase family vitro, and establish that conserved CLD motif N-terminal responsible for function. Furthermore, show NLRP3 novel protein. Specially, associates with NLRP3, mediates activating K63-linked...
Many clinical studies over the past decade have indicated positive outcomes for patients treated with Dynesys dynamic stabilization lumbar degenerative disease. However, long-term of spinal stenosis are rarely reported. The aim this study was to analyze and radiologic stabilization.Thirty-eight were from July 2008 March 2010. minimal duration follow-up 72 months. divided into spondylolisthesis groups according spondylolisthesis. Clinical evaluated using Oswestry Disability Index (ODI) visual...