A5024340488- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Retinoids in leukemia and cellular processes
- Circular RNAs in diseases
- Viral-associated cancers and disorders
- Antifungal resistance and susceptibility
- Histone Deacetylase Inhibitors Research
- Infectious Diseases and Mycology
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Childhood Cancer Survivors' Quality of Life
- ECG Monitoring and Analysis
- MicroRNA in disease regulation
Chinese PLA General Hospital
2016-2023
Cardiac arrhythmia, a condition characterized by irregular heartbeats, often serves as an early indication of various heart ailments. With the advent deep learning, numerous innovative models have been introduced for diagnosing arrhythmias using Electrocardiogram (ECG) signals. However, recent studies solely focus on performance models, neglecting interpretation their results. This leads to considerable lack transparency, posing significant risk in actual diagnostic process. To solve this...
BACKGROUND:The overall prognosis of acute myeloid leukemia (AML) patients with mixed-lineage (MLL) gene-positivity is unfavorable. In this study, we evaluated the expression levels MLL gene in AML patients. MATERIAL AND METHODS:We enrolled 68 gene-positive out 433 newly diagnosed patients, and 216 bone marrow samples were collected. Real-time fluorescence quantitative PCR (RQ-PCR) was used to precisely detect gene. RESULTS:We divided 41 into 2 groups according variation MRD (minimal residual...
The acute myeloid leukemia 1 (AML1)-eight-twenty-one (ETO) fusion protein generated by the t(8;21)(q22;q22) translocation is considered to display a crucial role in leukemogenesis AML. By focusing on anti-leukemia effects of eyes absent 4 (EYA4) gene AML cells, we investigated biologic and molecular mechanism associated with AML1-ETO expressed t(8;21) AML.Qualitative polymerase chain reaction (PCR), quantitative reverse transcription PCR (RT-PCR), Western blotting analysis were used observe...
The advanced extra-nodal NK/T-cell lymphoma (ENKTL) is highly aggressive and lacks effective treatment with a poor prognosis. This study aimed to investigate the effectiveness safety of autologous hematopoietic stem cell transplantation (ASCT) in CR1.Forty 121 patients ENKTL from four Chinese hospitals between January 2006 December 2021 who achieved first complete remission (CR1) received at least 4 cycles chemotherapy, were enrolled for analysis. Twenty ASCT as up-front consolidation...
To investigate the safety and efficacy of high dose tigecycline for treatment fibric neutrope-nia in acute leukemia patients after ineffectiveness carbapenems chemotherapy leukemia.The clinical data 41 with febrile ncutropenia received (100 mg q12h), who showed carbapenems, from 20151.30-2017.1. 29 our hospital were collected analyzed retrospectively. The temperature, inflammatory indicators as well hepatic renal function before compared.Among treated due to infection had been controled 34...
To analyze the therapeutic efficacy of different consolidation therapies after induction remission on Ph negative adolescent and young adults with acute B lymphoblastic leukemia, to explore effect risk factors prognosis.The treatment 80 B-ALL in patients 16-39 years old Hematology Department 301(65 cases) 309(15 hospital from 1999 2016 are retrospectively analyzed. The received combined chemotherapy 4 or 5 chemotherapeutic drugs (VDCLP/ VDLP/ DOLP/ IOLP). After protocols 3-5 cycls, then...
To investigate the clinical manifestation, features of laboratorial examination results and prognosis patients with Ph+/BCR-ABL+ acute myelogenous leukemia(AML).The data 5 AML admitted in Department Hematology Chinese PLA general hospital from July 2007 to May 2015 were collected their characteristics, laboatorial long-term survival analyzed.The median age cases was 39 years old, 2 splenomegaly. All assayed for BCR-ABL fusion gene, them accompanied other molecular abnormalities. In 4 cases,...
To evaluate the efficacy and safety of low-dose amphotericin B (AmB) in different antifungal strategies for treatment invasive fungal disease(IFD) patients with hematologic malignancies. Metheds: The clinical dada were collected analyzed retrospectively levels creatinine (Cr), urea nitrogen (BUN) potassium (K+) before after using AmB compared statistically analyzed.Among 97 cases, 2 cases diagnosed as disease (IFD), 11 probable IFD, 15 possible 69 undefined IFD. response rate all treated was...
To explore the transcriptional gene expression profile up-regulated in human macrophages stimulated by interferon-γ (IFN-γ) and underlying intracellular signaling mechanisms.RNA-seq was used to sequence compare differential profiles of macrophage cell line U937 before after IFN-γ stimulation, significantly genes were screened out, which verified fluorescence-based real-time quantitative polymerase chain reaction (qPCR) THP1 lines, respectively. JAK/STAT, MAPK/ERK PI3K/AKT pathway inhibitors...