A5102995465- Sperm and Testicular Function
- Geophysical and Geoelectrical Methods
- Reproductive Biology and Fertility
- Seismic Imaging and Inversion Techniques
- Reproductive Health and Technologies
- Geophysical Methods and Applications
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Seismic Waves and Analysis
- Cell death mechanisms and regulation
- Growth Hormone and Insulin-like Growth Factors
- Lymphoma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Genetics and Neurodevelopmental Disorders
- Image and Signal Denoising Methods
- CNS Lymphoma Diagnosis and Treatment
- Vasculitis and related conditions
- Organ Transplantation Techniques and Outcomes
- Moyamoya disease diagnosis and treatment
- Lung Cancer Treatments and Mutations
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
Guangzhou Medical University
2024
Guangzhou Women and Children Medical Center
2024
First People's Hospital of Chongqing
2022-2024
Guilin University of Technology
2017-2023
Gunma University
2020-2022
Yokohama City University
2020-2022
Northwest A&F University
2021
Central South University
2003-2020
Xiangya Hospital Central South University
2003-2020
Jilin Medical University
2014-2020
Quercetin, a well-known flavonoid, has been demonstrated to exert beneficial effects on intestinal functions and gut microbiota in birds. In this study, we investigated the of quercetin supplementation inflammatory responses, barrier microbial community LPS-challenged laying hens. A total two hundred eighty-eight 32-wk-old Jingfen No.6 hens were randomly assigned 3 groups, CON group, LC group LQ group. was fed with 0.4 mg/kg at end 12 wk, groups challenged intraperitoneally...
The effects of imeglimin, a novel antidiabetes agent, on β-cell function remain unclear. Here, we unveiled the impact imeglimin survival. Treatment with augmented mitochondrial function, enhanced insulin secretion, promoted proliferation, and improved survival in mouse islets. Imeglimin upregulated expression endoplasmic reticulum (ER)-related molecules, including Chop (Ddit3), Gadd34 (Ppp1r15a), Atf3, Sdf2l1, decreased eIF2α phosphorylation after treatment thapsigargin restored global...
Background . Gallbladder cancers (GBCs) are highly aggressive with high mortality. However, biological markers for the progression and prognosis of GBC currently unavailable in clinic. Objective To identify biomarkers predicting metastasis prognosis. Methods We examined ALDH1A3 GPX3 expressions 46 squamous cell/adenosquamous carcinomas (SC/ASC) 80 adenocarcinomas (AC) by using immunohistochemistry. Results Positive negative were significantly associated lymph node invasion SC/ASCs ACs....
This study aimed to evaluate the effects of fermented corn-soybean meal mixed feed on intestinal barrier function and cecal microbiota in laying hens. A total 360 Jingfen No.6 hens (22 wk-old) were assigned 4 dietary treatments, which offered basal diets (without antibiotics) containing 0, 4, 6 8% respectively. The results showed that pH value anti-nutritional factor concentrations lower than those unfermented (p < 0.05). Moreover, fermentation significantly increased crude protein content...
BACKGROUND Soft tissue tumors have various subtypes, among which sarcomas exhibit high malignant potential and poor prognosis. Malignant epithelioid tumor with GLI1 alterations was originally found in myopericytoma t(7;12) translocation. However, recent studies indicated that it is a distinct type characterized by multiple nodular distributions of oval or round cells rich capillary network lack specific immunophenotype. There are only few cases reported worldwide the optimal treatment still...
Abstract Background Insulin resistance can occur in all metabolic organs including the liver, adipose tissue, and skeletal muscles. Circulating soluble epidermal growth factor receptor (soluble EGFR) adipsin levels are altered obese diabetic mice possibly correlated with insulin both humans. Here, we investigated significance of EGFR as biomarkers for Japanese subjects type 2 diabetes. Methods We measured sera from 47 non-diabetic 106 diabetes using enzyme-linked immunosorbent assays...
Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type diabetes (T2DM); however, the pathological significance this increase UCP2 expression unclear. In study, we highlight molecular link between β-cells and β-cell failure by using genetically engineered mice human islets. β-cell-specific UCP2-overexpressing transgenic (βUCP2Tg) exhibited glucose intolerance reduction insulin secretion. Decreased function increased aldolase...
C-X-C chemokine receptor types 1 (CXCR1), a cell-surface G-protein-coupled has been found to be associated with tumorigenesis, development, and progression of some tumors. Previously, we have that CXCR1 overexpression is late-stage gastric adenocarcinoma. We also demonstrated knockdown could inhibit cell proliferation in vitro vivo. In this study, compared the changes protein expression profile between carcinoma MKN45 line CXCR1-knockdown by 2D electrophoresis. Among 101 quantified proteins,...
The structural integrity of the sperm is crucial for male fertility, defects in head-tail linkage and flagellar axoneme are associated with acephalic spermatozoa syndrome (ASS) multiple morphological abnormalities flagella (MMAF). Notably, impaired coupling apparatus (HTCA) often accompanies flagellum structure, however, molecular mechanisms underlying this phenomenon remain elusive. Here, we identified an evolutionarily conserved coiled-coil domain-containing (CCDC) protein, CCDC113, found...
The objective of this prospective study was to investigate further the clinical features patients with giant cell (temporal) arteritis (GCA). All diagnosed from July 1999 March 2001 at Department Neurology Second Xiangya Hospital in China were included. final diagnosis based on manifestations, a temporal artery biopsy, response steroid, and follow-up. American College Rheumatology (ACR) criteria for classification GCA tested identified. Sixteen identified; 13 (81.25%) fulfilled 1990 ACR GCA....
Abnormal hepatic insulin signaling is a cause or consequence of steatosis. DPP-4 inhibitors might be protective against fatty liver. We previously reported that the systemic inhibition receptor (IR) and IGF-1 (IGF1R) by administration OSI-906 (linsitinib), dual IR/IGF1R inhibitor, induced glucose intolerance, steatosis, lipoatrophy in mice. In present study, we investigated effects linagliptin, on steatosis OSI-906-treated Unlike high-fat diet-induced OSI-906-induced not characterized...
Efficient seismic phase picking is fundamental to signal processing. Phase methods based on neural networks show great potential in accurately signals with a low signal-to-noise ratio but require large training datasets. We present transductive transfer-learning-based support vector machine (TTL-SVM) algorithm for when the dataset possesses insufficient samples. An objective function of TTL-SVM, which incorporated pretraining classification process source domain that an adequate and quality...
Daxx was originally isolated as a Fas-binding protein. However, the in vivo function of Fas-induced apoptosis has remained enigmatic. Fas plays an important role homeostasis immune system. gene mutations lead to autoimmune-lymphoproliferation (lpr) diseases characterized by hyperplasia secondary lymphoid organs. It is well established that FADD adaptor binds Fas, and recruits/activates caspase 8. additional proteins including have also been indicated associate with Fas. proposed mediates...
The objective of this report was to explore the clinical features patients with cerebral infarction due giant cell (temporal) arteritis (GCA) and its characteristic changes in pathology, on computed tomography (CT) magnetic resonance imaging (MRI). Three cases GCA, treated during past 2 years, were analyzed. Their manifestations observed carefully, their temporal artery biopsies performed, immunohistochemistries done, CT as well MRI used. results showed that all had new-onset headache...
In our previous study, we found that the transforming growth factor (TGF)-beta1 enhanced metastatic and invasive potential of gastric cancer cells. Proteomics was employed in this study to further illustrate underlying molecular mechanisms. After two-dimensional electrophoresis, image analysis, spot identification, protein identification database three proteins, namely, glutathione-S-transferase-pi (GST-pi), cofilin heat shock 27 (HSP27), were be up-regulated TGF-beta1 treated SGC-7901 The...