A5100605503- Lymphoma Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Ovarian cancer diagnosis and treatment
- Protein Degradation and Inhibitors
- Urinary and Genital Oncology Studies
- Chronic Lymphocytic Leukemia Research
- Dark Matter and Cosmic Phenomena
- Astrophysics and Cosmic Phenomena
- BRCA gene mutations in cancer
- Solar and Space Plasma Dynamics
- Chronic Myeloid Leukemia Treatments
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Medical Research and Treatments
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Cancer Treatment and Pharmacology
- Hematological disorders and diagnostics
- CNS Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
Peking University
2016-2025
Peking University Third Hospital
2016-2025
Southeast University
2017-2025
Beijing Anzhen Hospital
2021-2024
Capital Medical University
2014-2024
Second Affiliated Hospital of Zhejiang University
2023
Yuncheng University
2022
Shanxi Medical University
2022
Yuncheng Central Hospital
2022
Beijing University of Chinese Medicine
2019-2022
The Alpha Magnetic Spectrometer (AMS) is a precision particle physics detector on the International Space Station (ISS) conducting unique, long-duration mission of fundamental research in space. objectives include precise studies origin dark matter, antimatter, and cosmic rays as well exploration new phenomena. Following 16-year period construction testing, precursor flight Shuttle, AMS was installed ISS May 19, 2011. In this report we present results based 120 billion charged ray events up...
We report the observation of new properties primary cosmic rays He, C, and O measured in rigidity (momentum/charge) range 2 GV to 3 TV with 90×10^{6} helium, 8.4×10^{6} carbon, 7.0×10^{6} oxygen nuclei collected by Alpha Magnetic Spectrometer (AMS) during first five years operation. Above 60 GV, these three spectra have identical dependence. They all deviate from a single power law above 200 harden an way.
We report on the observation of new properties secondary cosmic rays Li, Be, and B measured in rigidity (momentum per unit charge) range 1.9 GV to 3.3 TV with a total 5.4×10^{6} nuclei collected by AMS during first five years operation aboard International Space Station. The Li fluxes have an identical dependence above 7 all three 30 Li/Be flux ratio 2.0±0.1. deviate from single power law 200 way. This behavior has also been observed measurement primary He, C, O but dependences are...
We report the observation of new properties primary cosmic rays, neon (Ne), magnesium (Mg), and silicon (Si), measured in rigidity range 2.15 GV to 3.0 TV with 1.8×10^{6} Ne, 2.2×10^{6} Mg, 1.6×10^{6} Si nuclei collected by Alpha Magnetic Spectrometer experiment on International Space Station. The Ne Mg spectra have identical dependence above 3.65 GV. three 86.5 GV, deviate from a single power law 200 harden an way. Unexpectedly, rays is different He, C, O. This shows that O are two classes rays.
Precision measurements by the Alpha Magnetic Spectrometer (AMS) on International Space Station of ^{3}He and ^{4}He fluxes are presented. The based 100 million nuclei in rigidity range from 2.1 to 21 GV 18 1.9 15 collected May 2011 November 2017. We observed that exhibit nearly identical variations with time. relative magnitude decreases increasing rigidity. dependence ^{3}He/^{4}He flux ratio is measured for first Below 4 GV, was found have a significant long-term time dependence. Above be...
We present the precision measurement of 2824 daily helium fluxes in cosmic rays from May 20, 2011 to October 29, 2019 rigidity interval 1.71 100 GV based on 7.6×10^{8} nuclei collected with Alpha Magnetic Spectrometer (AMS) aboard International Space Station. The flux and proton ratio exhibit variations multiple timescales. In nearly all time intervals 2014 2018, we observed recurrent a period 27 days. Shorter periods 9 days 13.5 are 2016. strength three periodicities changes rigidity....
We report the properties of precision time structures cosmic nuclei He, Li, Be, B, C, N, and O fluxes over an 11-year solar cycle from May 2011 to November 2022 in rigidity range 1.92 60.3 GV. The show similar but not identical variations with amplitudes decreasing increasing rigidity. In particular, below 3.64 GV B fluxes, 2.15 are significantly less affected by modulation than He flux. observe that these differences linearly correlated spectral indices fluxes. This shows, a...
Precise knowledge of the charge and rigidity dependence secondary cosmic ray fluxes secondary-to-primary flux ratios is essential in understanding propagation. We report properties heavy fluorine F R range 2.15 GV to 2.9 TV based on 0.29 million events collected by Alpha Magnetic Spectrometer experiment International Space Station. The spectrum deviates from a single power law above 200 GV. heavier F/Si ratio distinctly different lighter B/O (or B/C) dependence. In particular, 10 GV, F/SiB/O...
To assess the efficacy and safety of a new conditioning regimen with chidamide BEAM for autologous hematopoietic stem cell transplantation (AHSCT) in patients lymphoma. Medical records further follow-up data from 85 lymphoma May 2015 to September 2020 our hospital were retrospectively collected analyzed. Among patients, 52 cases accepted 33 CBEAM followed by AHSCT. In group, 18 (54.5%) received AHSCT as salvage therapy, while only 26.9% (14 cases) group ( P < 0.01). resulted shorter...
Background: The role of B7-H3 in acute monocytic leukemia U937 cells has not been thoroughly investigated. Materials and methods: knockdown the cell line was performed using small hairpin (sh)RNA lentivirus transduction. effects on proliferation, cycle, migration, invasion were investigated by Cell Counting Kit-8 assay, methyl cellulose colony-forming propidium iodide staining, Transwell assays vitro. Changes growth inhibition apoptosis, when combined with chemotherapy drugs, determined...
B7-H3 (CD276), known as a member of B7 immunoregulatory family, is type I transmembrane glycoprotein aberrantly expressed in numerous types cancer and associated with poor prognosis. However, the role oncogenesis chemosensitivity mantle cell lymphoma (MCL) remains unknown. We determined effects downregulating expression on tumor progression sensitivity chemotherapeutic drug lymphoma. knockdown was performed using lentivirus transduction Maver Z138 lines, respectively. The proliferation,...
Frail elderly patients with newly diagnosed multiple myeloma (NDMM) have inferior survival and less benefit from high-dose therapies. This prospective study aimed to investigate the efficacy, safety, quality of life (QoL) induction treatment ixazomib/lenalidomide/dexamethasone (IRd) ixazomib/pegylated liposomal doxorubicin/dexamethasone (IDd) followed by ixazomib/dexamethasone (Id) maintenance therapy in frail, NDMM.
The survival rate of non-Hodgkin lymphoma (NHL) has steadily improved. However, osteoporosis introduced by treatment is prevalent and associated with increased mortality disability for patients NHL. We aimed to investigate factors impacting bone mineral density (BMD) reduction osteoporosis, the trend BMD after chemotherapy. Overall, 97 newly diagnosed follicular (FL) were retrospectively enrolled. CT attenuation values measured assess levels. Although 73.2% received calcium vitamin D...
Maintenance treatment is a pivotal part in the whole process management of multiple myeloma (MM), which further deepens response and improves survival. However, evidence maintenance non-transplant MM patients inadequate real-world practice. Here, we retrospectively analyzed efficacy survival 375 from 11 centers between 2010 2021 north China. After median seven cycles front-line regimens, there were 141, 79, 155 receiving lenalidomide (L-MT), bortezomib (B-MT), or thalidomide (T-MT),...
To explore the prognostic factors of elderly AML patients, as well application and value comprehensive geriatric assessment（CGA） in patients China, so to determine a suitable assessment method that can predict survival guide treatment Chinese people.Retrospective analysis was performed on medical records 84 aged over 60 years old, diagnosed our department from October 2007 December 2017, clinical, pathological evaluation related analyzed.The median age all 70 (60-91) ratio male female 1.9∶1...
BACKGROUND:The digestive tract is the most common site of extranodal involvement in diffuse large B cell lymphoma (DLBCL) and its prognostic evaluation different from that ordinary DLBCL. Currently, for gastrointestinal lymphoma, addition to Ann Arbor staging system, Lugano TNM systems are commonly used. However, there no effective model identify poor prognosis patients with localized (GI-DLBCL). MATERIAL AND METHODS:This study included 82 GI-DLBCL had a median follow-up 75 months, developed...
Several intracellular pathological processes have been reported to be regulated by the FAM19A5/S1PR1 signaling pathway. However, role of pathway in viability and proliferation mantle cell lymphoma is not completely understood. The task this study explore influence affecting survival growth lymphoma. shRNAs against FAM19A5 or S1PR1 were transfected into lymphom. Cell measured through MTT assay CCK8 assay, respectively. Our results demonstrated that loss significantly reduced lymphom, an...