A5101965447- Congenital Heart Disease Studies
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Multiple Myeloma Research and Treatments
- Osteomyelitis and Bone Disorders Research
- Cancer Immunotherapy and Biomarkers
- Bone and Joint Diseases
- Immunotherapy and Immune Responses
- Cardiac Valve Diseases and Treatments
- Perovskite Materials and Applications
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Cardiac Structural Anomalies and Repair
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Breast Cancer Treatment Studies
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Corneal surgery and disorders
- Viral-associated cancers and disorders
- interferon and immune responses
- Spondyloarthritis Studies and Treatments
- Liver physiology and pathology
- Protein Degradation and Inhibitors
Tianjin Medical University Cancer Institute and Hospital
2016-2025
Dalian Ocean University
2025
Ministry of Agriculture and Rural Affairs
2025
Collaborative Innovation Center of Chemistry for Energy Materials
2024
University of Science and Technology of China
2024
Peking University
2019-2024
Peking University Third Hospital
2019-2024
Capital Medical University
2010-2024
Beijing Obstetrics and Gynecology Hospital
2023-2024
LabCorp (United States)
2024
Timely and accurate identification of molecular alterations in solid tumors is essential for proper management patients with advanced cancers. This has created a need rapid, scalable comprehensive genomic profiling (CGP) systems that detect an increasing number therapeutically-relevant variant types signatures. In this study, we assessed the analytical performance TruSight Oncology 500 High-Throughput assay detection somatic from formalin-fixed paraffin-embedded tissue specimens. parallel,...
Breast cancer is a leading cause of morbidity and mortality among young women, who often experience more aggressive disease, which may impact their treatment responses long-term prognoses. Understanding the effectiveness neoadjuvant chemotherapy (NAC) versus adjuvant (AC) in this specific population critical for optimizing strategies improving This research was conducted to compare prognoses women (≤35 years old) with early-stage hormone receptor (HR)-positive, human epidermal growth factor...
Gravity acts on the circulatory system to decrease arterial blood pressure (AP) by causing redistribution and reduced venous return. To evaluate roles of baroreflex vestibulosympathetic reflex (VSR) in maintaining AP during gravitational stress, we measured AP, heart rate (HR), renal sympathetic nerve activity (RSNA) four groups conscious rats, which were either intact or had vestibular lesions (VL), sinoaortic denervation (SAD), VL plus SAD (VL + SAD). The rats exposed 3 G dorsoventral axis...
The co-transport of contaminants by soil colloids can generate substantial environmental risk, and this behavior is greatly affected conditions. In study, AF4-ICP-MS was used to investigate the size distribution composition Cd/Pb-bearing colloids; saturated sand column experiments were impact on transport Cd/Pb under different pH ionic strength characterization showed that natural primarily associated with two sizes ranges: 0.3–35 KDa (F1, fine nanoparticles) 280 KDa–450 nm (F2, larger...
Abstract Background Contemporary to the rapidly evolving landscape of cancer immunotherapy is equally changing understanding immune tumor microenvironments (TMEs) which crucial success these therapies. Their reliance on a robust host response necessitates clinical grade measurements TMEs at diagnosis. In this study, we describe stable immunogenic profile describing in multiple types with ability predict benefit from checkpoint inhibitors (ICIs). Methods A signature (TIGS) was derived...
PurposeThe potential recurrence rate of malignant phyllodes tumors (MPTs) the breast is high, and prognostic factors are still unclear. We therefore aim to study affecting outcome MPTs.MethodsA retrospective review MPT patients treated from 2006 2020 at our institution was conducted. Univariate multivariate Cox proportional hazard models were used examine influence different variables on RFS. Moreover, significant combined construct nomogram predict probability relapse occurring in patients....
Background: KEYNOTE-522 resulted in FDA approval of the immune checkpoint inhibitor pembrolizumab combination with neoadjuvant chemotherapy for patients early-stage, high-risk, triple-negative breast cancer (TNBC). Unfortunately, is associated several immune-related adverse events (irAEs). We aimed to identify potential tumor microenvironment (TME) biomarkers which could predict who may attain pathological complete response (pCR) alone and be spared use anti-PD-1 immunotherapy. Methods:...
The understanding of molecular characteristics HER2-low breast cancer is evolving since the establishment trastuzumab deruxtecan. Here, we explore differences in expression patterns immune-related genes tumor immune microenvironment (TME) and survival between HER2-zero cancers.
Premature ductus arteriosus constriction (DA Con) can result in right ventricular enlargement, hypertrophy, and tricuspid regurgitation.This study retrospectively analyzed 34 singleton fetuses that underwent fetal echocardiography with a diagnosis of DA Con (16 cases mild to moderate, 18 moderate severe) 45 healthy fetuses. The morphology function parameters cardiac, as well the 24-Segment ventricles, were compared between group controls, severe groups, using heart quantification (FHQ)...
Although studies have compared fetal echo results with autopsy findings, investigations that multiple categories of congenital heart disease (CHD) are lacking. This study, therefore, aimed to compare echocardiographic diagnoses cardiac findings and evaluate the diagnostic accuracy echocardiography (FE).One hundred seventy-one specimens from fetuses diagnosed CHD were collected after termination pregnancy, autopsies performed. FE degree their correspondence was categorized as "complete...
This study aimed to determine ultrasonic image characteristics that enable differentiation between cholesterol and adenomatous polyps assess the diagnostic efficacy of combining conventional ultrasound (CUS) with contrast-enhanced (CEUS).Eighty-nine patients gallbladder 1-2 cm in diameter were enrolled examined by CUS CEUS before cholecystectomy. The appearances on recorded analyzed. receiver operating characteristic (ROC) curve was used calculate optimal size threshold for distinguishing...
Aims: Primary hepatocellular carcinoma (HCC) is a common malignancy often related to hepatitis viral infection. Smad4 known mediate the TGF-<TEX>${\beta}$</TEX> pathway suppress tumorigenesis. However, function of in HCC still controversial. In this study we compared levels tissues with or without virus infection and adjacent normal-appearing liver. Methods: Samples from patients were analyzed for protein mRNA expression by immunohistochemistry (IHC), RT-PCR Western blotting. Results: We...
Soft X-ray imaging is a powerful tool to explore the structure of cells, probe material with nanometer resolution, and investigate energetic phenomena in universe. Conventional soft image sensors are by large Si-based charge coupled devices that suffer from low frame rates, complex fabrication processes, mechanical inflexibility, required cooling below -60 °C. Here, photodiode reported based on low-cost metal halide perovskite comparable performance commercial device. Nanothrough network...