A5059880417- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Tumors and Oncological Cases
- dental development and anomalies
- Salivary Gland Tumors Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Teratomas and Epidermoid Cysts
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Cancer and Skin Lesions
- Soft tissue tumor case studies
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Multiple Sclerosis Research Studies
- Lipoproteins and Cardiovascular Health
- Head and Neck Anomalies
- Peripheral Neuropathies and Disorders
- Advanced biosensing and bioanalysis techniques
- FOXO transcription factor regulation
- Oral and Craniofacial Lesions
- Thyroid Cancer Diagnosis and Treatment
- Genetic and rare skin diseases.
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Peking University
2014-2025
Tianjin Medical University General Hospital
2009-2024
Stomatology Hospital
2008-2024
National Clinical Research Center for Digestive Diseases
2024
Henan Polytechnic University
2021-2024
National Clinical Research
2023-2024
King University
2023-2024
Chengdu University of Traditional Chinese Medicine
2023
Tianjin Medical University
2009-2021
Abstract Context.—Orthokeratinized odontogenic cyst (OOC) is a relatively uncommon developmental comprising about 10% of cases that had been previously coded as keratocysts. Odontogenic keratocyst was designated keratocystic tumor (KCOT) in the new World Health Organization classification and OOC should be distinguished from KCOT for differences histologic features biologic behavior. Objective.—To analyze clinicopathologic 61 Chinese population. Design.—Clinicopathologic analysis performed...
Abstract Context.—Odontogenic myxoma is an uncommon tumor that has the potential for extensive destruction of jaws. Objective.—To document clinical, pathologic, and behavioral features odontogenic myxomas. Design.—Histologic immunocytochemical examinations were performed on myxomas from 25 Chinese patients. Clinical available follow-up data analyzed. Results.—In present series, 13 male 12 female. The age at diagnosis ranged 6 to 66 years, with a mean 28.8 years. Twelve tumors involved...
Abstract Insulin resistance is a key driver of type 2 diabetes (T2D) and characterized by defective insulin receptor (INSR) signalling. Although surface INSR downregulation well-established contributor to resistance, the underlying molecular mechanisms remain obscure. Here we show that E3 ubiquitin ligase MARCH1 impairs cellular action degrading cell INSR. Using large-scale RNA interference screen, identify as negative regulator March1 loss-of-function enhances, overexpression impairs,...
Highly efficient removal of bilirubin from whole blood directly by hemoperfusion for liver failure therapy remains a challenge in the clinical field due to low adsorption capacity, poor mechanical strength and biocompatibility adsorbents. In this work, new class nanocomposite adsorbents was constructed through an inorganic-organic co-crosslinked network between vinyltriethoxysilane (VTES)-functionalized hydroxyapatite nanoparticles (V-Hap) non-ionic styrene-divinylbenzene (PS-DVB) resins...
PTCH1 has been identified as the gene responsible for nevoid basal cell carcinoma syndrome (NBCCS). Keratocystic odontogenic tumors (KCOT) are aggressive jaw lesions that may occur in isolation or association with NBCCS. The aim of this study was to investigate genetic and/or epigenetic mechanisms inactivation patients NBCCS and related sporadic KCOTs.Loss heterozygosity analyzed 44 (15 NBCCS-related 29 KCOTs), all whom were previously mutations. Allelic location established carrying two...
Oncogene-induced DNA methylation-mediated transcriptional silencing of tumor suppressors frequently occurs in cancer, but the mechanism and functional role this oncogenesis are not fully understood. Here, we show that oncogenic epidermal growth factor receptor (EGFR) induces multiple unrelated lung adenocarcinomas glioblastomas by inhibiting demethylase TET oncogene family member 1 (TET1) via C/EBPα transcription factor. After EGFR inhibition, TET1 binds to suppressor promoters their...
Oral cancer is a common malignant tumor in the maxillofacial region. Surgical resection preferred treatment, but severe functional impairment after surgery forces us to look for noninvasive treatments. As promising treatment method, photodynamic therapy (PDT) has received widespread attention field of therapy, inefficient uptake capacity cells and damage repair mechanisms limit actual therapeutic effect. The establishment targeted function autophagy inhibition strategy considered be an...
Abstract Background Clinical diagnosis based on machine learning usually uses case samples as training samples, and to construct disease prediction models characterized by descriptive texts of clinical manifestations. However, the problem sample imbalance often exists in medical field, which leads a decrease classification performance learning. Methods To solve dataset, we propose hybrid sampling algorithm combining synthetic minority over-sampling technique (SMOTE) edited nearest neighbor...
ABSTRACT Background Fibrous dysplasia (FD), caused by activating mutations of GNAS , is a skeletal disorder with considerable clinicopathological heterogeneity. Although prevalent such as R201C and R201H dominate in FD, limited number rare mutations, including R201S, R201G, Q227L, have been documented. The scarcity information concerning these uncommon motivates our investigation, seeking to enhance comprehension this less‐explored subgroup within FD. Methods This study introduces three...
ABSTRACT Objects This retrospective study aimed to investigate the clinical characteristics and prognostic features of acinic cell carcinoma (AciCC) salivary gland. Methods One Hundred Ninety‐nine cases AciCC were retrospectively reviewed. Clinical outcomes systematically collected. Recurrence‐free survival, metastases‐free overall survival patients with different variables compared using Kaplan–Meier method Cox univariate regression. Results A total 199 included (70 men, 129 women; mean...
ABSTRACT Objectives To investigate the prevalence of BRAF , SMO KRAS HRAS NRAS FGRF2 and CTNNB1 gene mutations in Chinese ameloblastoma (AM) patients explore their associations with clinical characteristics. Materials Methods DNA was extracted from 89 formalin‐fixed paraffin‐embedded AM samples (9 unicystic 80 conventional). PCR Sanger sequencing were used to detect mutations, followed by statistical analysis assess correlations between variables. Results V600E significantly prevalent,...
Keratocystic odontogenic tumors (KCOTs, previously known as keratocysts) are aggressive jaw lesions that may occur in isolation or association with nevoid basal cell carcinoma syndrome (NBCCS). Mutations the PTCH1 ( PTCH) gene responsible for NBCCS and related associated this syndrome. SMO have been identified medulloblastoma, both of which features NBCCS. To clarify role KCOTs, we undertook mutational analysis 20 sporadic 10 NBCCS-associated SMO, additional cases KCOTs status were also...
Odontogenic keratocysts are relatively common lesions that may occur in isolation or association with nevoid basal cell carcinoma syndrome (or Gorlin syndrome). The PTCH gene has been reported to be associated syndrome. We investigated 10 cases of non-syndromic and two other syndrome, looking for mutations. Four novel 1 known mutations were identified five individual patients. Of the 5 identified, 2 germ-line (2619C>A; 1338_1339insGCG) cysts 3 somatic (3124_3129dupGTGTGC;...
Background N ‐α‐acetyltransferase 10 protein (Naa10p) is a potential prognostic biomarker that modulates the phenotypes of several cancer types. Carcinoembryonic antigen ( CEA ) currently most well‐known for detection epithelial malignancies. Our objective was to evaluate clinical value Naa10p, , and their combined diagnosis oral squamous cell carcinoma OSCC ). Methods This study included 202 individuals: 112 patients with 30 premalignant lesions OPML s), 60 cancer‐free without as control....
Abstract In the present study, we explored clinical and immunological characteristics of 575 uterine corpus endometrial carcinoma (UCEC) samples obtained from The Cancer Genome Atlas (TCGA) using ESTIMATE CIBERSORT algorithms. First, Kaplan–Meier univariate Cox regression analyses indicated that immune cell score was a prognostic factor for overall survival (OS) recurrence-free (RFS). Multivariate analysis further revealed an independent UCEC patients. Second, investigated correlation...
The updated classification of odontogenic tumors by the World Health Organization (WHO) has included adenoid ameloblastoma (AA) as a distinct entity. However, distinguishing between AA and dentinogenic ghost cell tumor (DGCT) can still be challenging due to their significant morphologic similarities. In this study, we aimed compare clinicopathologic, immunohistochemical, molecular characteristics DGCT aid in differentiation shed light on pathologic mechanisms. Thirteen cases 14 (15 samples)...
Background Cancer diagnosis based on machine learning has become a popular application direction. Support vector (SVM), as classical algorithm, been widely used in cancer because of its advantages high-dimensional and small sample data. However, due to the feature space high redundancy gene expression data, SVM faces problem poor classification effect when dealing with such Methods Based this, this paper proposes hybrid selection algorithm combining information gain grouping particle swarm...
This study determined the effects of rumen-protected choline (RPC) on growth performance, blood lipids, meat quality and expression genes involved in fatty-acid metabolism young lambs. A total 24 Dorper × Hu lambs (about 20 kg body weight) were kept individual pens fed diets with 0%, 0.25%, 0.50% 0.75% RPC for 60 d. Supplementation 0.25% increased average daily gain lambs, whereas treatments had no significant effect feed intake. The pH values at both, dripping loss shear force meat,...
Abstract Context.—Glial choristoma is an uncommon developmental abnormality typically presenting at birth or in early childhood. The nasal region most frequently affected. Palate, tongue, cheek, scalp, and orbit can also be affected but these occurrences are relatively rare. Objective.—To report 6 cases of glial arising the oral maxillofacial to document clinical pathologic features lesions. Design.—Histologic immunocytochemical examinations were performed on choristoma. Biologic behavior,...