Theranostic systems that permit both diagnosis and treatment in vivo are highly appealing means by which to meet the demands of precision medicine. However, most such remain subject issues related complex molecular design synthesis, potential toxicity, possible photoactivity changes. Herein, a novel supramolecular theranostic strategy involving biomarker protein activation (BPA) host-guest is proposed. To exemplify BPA, facile "one-for-all" nanotheranostic agent for albumin detection cancer...

Binary iron-gallium (Galfenol) alloys have large magnetostrictions over a wide temperature range. Single crystal measurements show that additions of 2at.% or greater 3d and 4d transition elements with fewer (V, Cr, Mo, Mn) more (Co, Ni, Rh) valence electrons than Fe, all reduce the saturation magnetostriction. Kawamiya Adachi [J. Magn. Mater. 31–34, 145 (1983)] reported D03 structure is stabilized by electron∕atom ratios both less iron iron. If ordering decreases magnetostriction, maximum...

Sparse Representation-based Classification (SRC) is a newly introduced algorithm for face recognition, notable its robust performance to occlusions and corruptions. Local Binary Patterns (LBP) very powerful method describe the texture shape of images. In this paper, we propose novel facial expression recognition based on sparse representation LBP features. Extensive experiments Japanese Female Facial Expression (JAFFE) database are conducted. The experiment results show that new has better...

Cryptococcal meningoencephalitis is a fungal infection that predominantly affects immunocompromised patients and uniformly fatal if left untreated. Timely diagnosis difficult, screening or prophylactic measures have generally not been successful. Thus, we need better understanding of early, asymptomatic pathogenesis. Inhaled cryptococci must survive the host immune response, escape lung, persist within bloodstream in order to reach invade brain. Here took advantage zebrafish larval model...

To transfer the preplan for head and neck brachytherapy to clinical implantation procedure, a preplan-based 3D-printed individual template needle insertion guidance had previously been designed used. The accuracy of using this kind was assessed in vivo In study, 25 patients with tumors were implanted 125I radioactive seeds under template. Patients divided into four groups based on site insertion: parotid masseter region group (nine patients); maxillary paranasal (eight submandibular upper...

Oral cancer is a common malignant tumor in the maxillofacial region. Surgical resection preferred treatment, but severe functional impairment after surgery forces us to look for noninvasive treatments. As promising treatment method, photodynamic therapy (PDT) has received widespread attention field of therapy, inefficient uptake capacity cells and damage repair mechanisms limit actual therapeutic effect. The establishment targeted function autophagy inhibition strategy considered be an...

To evaluate the clinical efficacy of ultrasound-guided needle knife release with different pathways for carpal tunnel syndrome (CTS). Sixty CTS patients were randomly divided into a transverse group and longitudinal group, 30 in each group. The received under ultrasound above below median nerve along short axis, while long axis. patients' visual analogue scale (VAS) scores, Levine cross-section area (CSA) assessed before treatment, on 7th, 14th, 30th days after treatment. conduction indexes...

To enhance the accuracy of radioactive seed implants in head and neck, a digital model individual template, containing information simultaneously on needle pathway facial features, was designed to guide implantation with CT imaging. Thirty-one patients recurrent local advanced malignant tumors neck after prior surgery radiotherapy were involved this study. Before 125I implants, received scans based 0.75mm thickness. And brachytherapy treatment planning system (BTPS) software used make plan...

To retrospectively review the impact of outbreak coronavirus disease 2019 (COVID-19) on services in oral emergency room. A statistical analysis epidemiological characteristics and patients' diagnoses treatments Emergency Department Peking University Hospital Stomatology during COVID-19 2020 compared with those Beijing, China. There were fewer total visits than (P = 0.001), proportions patients who children, adolescents elderly people lower < 0.001). The acute toothache infections higher...

Abstract The bacterial microbiota in the gut varies among species, as well with habitat, diet, age, and other factors. Intestinal homeostasis allows a host to adjust metabolic immune performances response environmental changes. Therefore, potential implications of sustaining health have gained increasing attention field endangered animal conservation. However, effect intraspecies genetic variation on is unknown. Moreover, little known about complexity mycobiota. Tigers are listed raising...

A clinical review with an analysis of prognostic factors, including characteristics, histological classifications, presenting symptoms/signs and treatment modalities, was conducted in 67 patients primary malignant neoplasms the trachea who were seen at Veterans General Hospital-Taipei between 1979 1994. The incidence tracheal cancer 140 times less than lung during this period. Delayed diagnosis more 6 months after onset symptoms occurred one-third owing to lack specific indicative disease....

Transmission synchrotron diffraction was employed to characterize the Ga ordering in magnetostrictive ${\text{Fe}}_{100\ensuremath{-}x}{\text{Ga}}_{x}$ alloys with concentrations from 0 $20.3\text{ }\text{at}\text{.}\text{ }\mathrm{%}$. The experiments focused on development of atomic short-range (SRO) by analysis diffuse scattering appearing at superlattice positions $\text{D}{0}_{3}$ ordered alloy structure. No SRO found for less than $4\text{ Between 13 and }\mathrm{%}$,...

Oral squamous cell carcinoma (OSCC) is predominantly a disease of middle-aged men with long-term exposure to tobacco and alcohol. An increasing trend has been reported at younger age worldwide. Clinical records 100 patients under the 45 years treated specifically for oral cavity SCC in our hospital during 10-year period were retrospectively analyzed calculate survival rates. obvious male predominance coincided smoking among Chinese young individuals female more likely have no traditional...

ABSTRACT Invasive fungal diseases are generally difficult to treat and often fatal. The therapeutic agents available fungi limited, there is a critical need for new combat these deadly infections. Antifungal compound development has been hindered by the challenge of creating that highly active against pathogens but not toxic host. Host defense peptides (HDPs) produced eukaryotes as component innate immune response have served inspiration many antibacterial compounds. HDP mimics, however,...

Spores are required for long-term survival of many organisms, including most fungi. For the majority fatal human fungal pathogens, spore germination is key process to initiate vegetative growth and ultimately cause disease. Because pathogenesis, could hold fungal-specific targets new antifungal drug development. Compounds that inhibit be developed into high efficacy, low-toxicity drugs use in prevention and/or treatment spore-mediated diseases. To identify with ability pathogenic...

Several biallelic truncating and missense variants of the gem nuclear organelle-associated protein 5 (GEMIN5) gene have been reported to cause neurodevelopmental disorders characterized by cerebellar atrophy, intellectual disability, motor dysfunction. However, association between GEMIN5 early-infantile developmental epileptic encephalopathies (EIDEEs) has not reported.

Background: Solitary fibrous tumors of the pleura (SFTP) are rare. The aims this study were (1) to characterize their clinicopathological features more precisely; (2) determine whether an immunohistochemical (IHC) can be helpful in distinguishing benign from malignant SFTPs; and (3) provide complete information better predict prognosis. Methods: Microscopic examinations tumorous specimens 15 patients repeated reclassified. In addition evaluating variables, expressions p16, p53, Ki-67,...

Spores are an essential cell type required for long-term survival across diverse organisms in the tree of life and a hallmark fungal reproduction, persistence, dispersal. Among human pathogens, spores presumed infectious particles, but relatively little is known about this robust type. Here we used meningitis-causing fungus Cryptococcus neoformans to determine roles spore-resident proteins spore biology. Using highly sensitive nanoscale liquid chromatography/mass spectrometry, compared...