A5100681974- Laser Applications in Dentistry and Medicine
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Dental Research and COVID-19
- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Endodontics and Root Canal Treatments
- Photoreceptor and optogenetics research
- Dental materials and restorations
- Hydrogen's biological and therapeutic effects
- Infrared Thermography in Medicine
- Retinal Imaging and Analysis
- Advanced biosensing and bioanalysis techniques
- Cell death mechanisms and regulation
- 3D Printing in Biomedical Research
- Oral microbiology and periodontitis research
- Dental Anxiety and Anesthesia Techniques
- Graphene and Nanomaterials Applications
- Retinal Diseases and Treatments
- Fungal Biology and Applications
- Cancer, Hypoxia, and Metabolism
- Effects of Radiation Exposure
- Luminescence and Fluorescent Materials
- Glaucoma and retinal disorders
- Polymer Surface Interaction Studies
Peking University
2016-2025
National Clinical Research Center for Digestive Diseases
2020-2024
Stomatology Hospital
2016-2023
University of Shanghai for Science and Technology
2020-2021
Massachusetts General Hospital
2016-2019
Liaocheng People's Hospital
2019
Harvard University
2016-2018
Chinese Academy of Tropical Agricultural Sciences
2016
Academy of Military Medical Sciences
2013
China Academy of Engineering Physics
2011
Abstract Human adipose-derived stem cells (hASCs) have the potential to differentiate into several different cell types including osteoblasts. Photobiomodulation (PBM) or low level laser therapy (LLLT) using red near-infrared wavelengths has been reported effects on both proliferation and osteogenic differentiation of cells. We examined delivering four (420 nm, 540 660 810 nm) at same dose (3 J/cm 2 ) five times (every two days) hASCs cultured in medium over three weeks. measured expression...
Abstract Efficient antimicrobials are urgently needed for the treatment of bacterial biofilms due to their resistance traditional drugs. Photodynamic therapy (PDT) is a new strategy that has been used combat bacteria and biofilms. Cationic photosensitizers, particularly cationic photodynamic nanoagents, usually chosen enhance antimicrobial activity. However, positively charged nanoparticles (NPs) beneficial cellular internalization, which causes increased cell cytotoxicity. Herein,...
We previously showed that blue (415 nm) and green (540 wavelengths were more effective in stimulating osteoblast differentiation of human adipose-derived stem cells (hASC), compared to red (660 near-infrared (NIR, 810 nm). Intracellular calcium was higher after blue/green, could be inhibited by the ion channel blocker, capsazepine. In present study we asked what effect these four on proliferation hASC? When cultured medium there a clear difference between blue/green which red/NIR stimulated...
Theranostic systems that permit both diagnosis and treatment in vivo are highly appealing means by which to meet the demands of precision medicine. However, most such remain subject issues related complex molecular design synthesis, potential toxicity, possible photoactivity changes. Herein, a novel supramolecular theranostic strategy involving biomarker protein activation (BPA) host-guest is proposed. To exemplify BPA, facile "one-for-all" nanotheranostic agent for albumin detection cancer...
Abstract A key characteristic of radiation‐induced oral mucositis (RIOM) is oxidative stress mediated by the “reactive oxygen species (ROS) storm” generated from water radiolysis, resulting in severe pathological lesions, accompanied a disturbance microbiota. Therefore, sprayable situ hydrogel loaded with “free radical sponge” fullerenols (FOH) developed as antioxidant agent for RIOM radioprotection. Inspired marine organisms, 3,4,5‐trihydroxyphenylalanine (TOPA) which enriched ascidians...
Abstract Single‐atom nanozymes (SAzymes), with their superior enzyme‐like catalytic activity, have emerged as promising candidates for oncology therapeutics. The well‐defined structures of SAzymes make them well predictable by experiences and theoretical calculation. However, the effects metal center species coordination environments on activity are variable, screening artificial experiments is challenging. High‐throughput can rapidly select optimal thus better application in tumor therapy...
Photocatalysis describes the excitation of titanium dioxide nanoparticles (a wide-band gap semiconductor) by UVA light to produce reactive oxygen species (ROS) that can destroy many organic molecules. This photocatalysis process is used for environmental remediation, while antimicrobial kill classes microorganisms and be sterilize water surfaces possibly treat infections. Here we show addition nontoxic inorganic salt potassium iodide TiO2 (P25) excited potentiated killing Gram-positive...
Abstract Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd‐DTPA), are routinely used for detecting tumors at an early stage. However, the rapid clearance by kidney of Gd‐DTPA leads to short blood circulation time, which limits further improvement between tumorous and normal tissue. Inspired deformability red cells, improves their circulation, this work fabricates a novel MRI agent incorporating into deformable mesoporous organosilica nanoparticles (D‐MON). In vivo...
Oral squamous cell carcinoma (OSCC) is one of the most common oral malignancies. Radiotherapy primary noninvasive treatment OSCC for avoiding surgery-induced facial deformities and impaired function. However, specificity in situ limits radiotherapeutic effects because hypoxia-induced low radiosensitivity tumors radiation tolerance surrounding normal tissues. Here, we design a highly efficient low-toxic radiosensitization strategy. On hand, biocompatible poly(vinyl pyrrolidone)-modified...
The present study was to determine the role of Toll-like receptor 4 (TLR4) signaling in inflammation and alveolar bone resorption using a murine model Porphyromonas gingivalis-associated ligature-induced peri-implantitis.Smooth surface titanium implants were placed left maxilla 6 weeks after extraction first second molars Wild-type (WT) TLR4-/- (TLR4 KO) mice. Silk ligatures immersed with P. gingivalis tied around implant placement confirmation osteointegration. Two ligation, resorption,...
Streptococcus mutans (S. mutans) is considered the primary bacteria responsible for dental caries, and specific recognition fluorescence labeling can achieve accurate detection early diagnosis of oral diseases such as caries. However, due to weak stability traditional imaging probes in solution a lack functions, there are still significant challenges fluorescent caries lesions. Herein, we report peptide-QDs composite probe that high-performance S. enable susceptible sites hidden carious...
Background and Objectives This study was performed to compare the use of methylene blue (MB) rose bengal (RB) in antimicrobial photodynamic therapy (PDT) targeting Enterococcus faecalis ( E. ) bacteria planktonic biofilm forms with potassium iodide (KI) potentiation. Study Design/Materials Methods form were exposed PDT protocols activating MB RB, or without KI potentiation, following laser irradiation different exposure times, 60 mW/cm 2 power, photosensitizer agent (PS)/potentiator...
Houttuynia cordata (H. cordata) is the most common herb as a food and traditional Chinese medicine. Currently, studies on its toxicity have mainly focused hepatotoxicity. However, potential embryotoxicity by long-term exposure often overlooked. Objective: To investigate effects of H. embryonic development mechanism combining network pharmacology, molecular docking, in vitro experimental methods. Methods: The embryos were evaluated. Zebrafish embryoid bodies administered to observe...
Abstract This study aimed to evaluate the diagnostic performance of a non-radiating, noninvasive infrared (IR) thermal imaging system in detection cervical lymph node metastasis from oral cavity cancer. In this prospective clinical trial, total 90 cancer patients suspected having underwent IR neck prior dissection. Analysis images was performed by two methods: manual qualitative analysis and automatic an entropy-gradient support vector machine (EGSVM). The efficacies EGSVM-based...
Abstract Photobiomodulation (PBM) has recently started to gain popularity in clinical therapeutics. Visible light, particular, plays a critical role osteogenesis modulation. However, the limited penetration depth of visible light biological tissues constrained application this technology vivo. Herein green light‐based PBM technique with implantable and biodegradable poly(L‐lactic acid) & poly(L‐actic‐co‐glycolic optical fibers achieve accelerated bone regeneration is explored....