A5016535802- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Dermatology and Skin Diseases
- Essential Oils and Antimicrobial Activity
- Drug Solubulity and Delivery Systems
- Fluorine in Organic Chemistry
- Toxin Mechanisms and Immunotoxins
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Ginseng Biological Effects and Applications
- Polymer Surface Interaction Studies
- Andrographolide Research and Applications
- Potato Plant Research
- Lipid metabolism and disorders
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Neuroblastoma Research and Treatments
- Chemical Synthesis and Analysis
- Contact Dermatitis and Allergies
- Synthesis and Biological Evaluation
- Ferroptosis and cancer prognosis
- Lipid Membrane Structure and Behavior
- MicroRNA in disease regulation
- Synthetic Organic Chemistry Methods
China Medical University
2011-2025
Hebei North University
2024
Shenyang Pharmaceutical University
2009-2023
China Pharmaceutical University
2015-2023
University of Chinese Academy of Sciences
2023
National Center for Nanoscience and Technology
2022-2023
Shanghai Institute of Organic Chemistry
2023
Shanghai University of Electric Power
2023
Electric Power University
2023
Chinese Academy of Sciences
2023
Transdermal drug delivery has been accepted as a potential non-invasive route of administration, with advantages prolonged therapeutic action, decreased side effect, easy use and better patient compliance. However, development transdermal products is primarily hindered by the low permeability skin. To overcome this barrier numerous new chemicals have synthesized permeation enhancers for delivery. In review, we presented an overview investigations in field, further implications on selection...
Skin wound especially burn injury is a major threat for public health. One of the pursuits in current healing research to identify new promising biological materials, which can not only promote tissue repair but also reduce scar formation. In this study, potentials α-lactalbumin (ALA), tryptophan-rich dietary protein acting as precursor neurotransmitter serotonin, and formation were investigated. The ALA was initially electrospun with polycaprolactone (PCL) accomplish nanofibrous mats...
The use of polydopamine-based bioinspired nanomaterials has shed new light on advanced drug delivery arising from their efficient surface functionalization. More recently, the polydopamine self-assemblies formed in two different modalities, i.e., nonporous and mesoporous nanoparticles, have begun to attract attention due expedient versatile properties. However, possibility for dermal local therapy, as well interaction with skin, not yet been demonstrated. Our study aimed compare explore...
Sonodynamic therapy (SDT) is a novel therapeutic modality that effective for the noninvasive treatment of dermatological diseases. As ubiquitous large class sonosensitizers, however, porphyrins suffer from poor skin permeability and inefficient generation reactive oxygen species. Herein, different-sized porphyrinic metal–organic frameworks (MOFs), PCN-224 (90, 125, 200 nm), were developed via coordination tetra-kis(4-carboxyphenyl) porphyrin (TCPP) metal zirconium to enhance local delivery...
Paclitaxel (PTX) remains a cornerstone in the treatment of locally advanced and metastatic lung cancer. To improve its therapeutic indices against cancer, novel redox-sensitive pullulan/PTX-based prodrug NPs (PULL-SS-PTX NPs) were accomplished, which further surface-decorated with transferrin (TF), cancer cell-targeting ligand, to afford TF-PULL-SS-PTX NPs. These (drug content, >37% average size, 134-163 nm) rapidly dismantled their self-assembled architecture upon exposure simulated...
A kind of nanoparticular system based on zeolitic imidazolate framework-8 (ZIF-8) and polydopamine (PDA) modification was developed for improving the dermal delivery 5-fluorouracil (5-FU).
The present study was aimed at the comparison of pharmacokinetics pure chlorogenic acid and extract Solanum lyratum Thunb. animals were allocated to two groups, administered or S. a dose 50.0 mg/kg orally. Blood samples collected up 8 h post-dosing. Plasma analyses performed using an HPLC method with UV detector. pharmacokinetic parameters evaluated non-compartmental assessment. Significant differences existed in groups for AUC0-t , AUC0-∞ CLz/F. reliable successfully applied determination...
Panax ginseng is becoming a promising antidiabetic herbal medication. As the main active constituents of ginseng, ginsenosides are well known, poorly absorbed chemicals. However, pharmacokinetic behavior under diabetic conditions not fully understood. This study aimed to explore alterations and potential mechanisms ginsenoside Rb1 in rats compared with normal fed high-fat diet. Systemic exposure (area concentration-time curve extrapolated from zero infinity) was significantly increased after...
PARP7 plays a crucial role in cancer immunity. The inhibition of has shown potential boosting the immune response against cancer, making it an attractive target for immunotherapy. Herein, we employed rigid constraint strategy (reduction molecular flexibility) to design and synthesize series novel indazole-7-carboxamide derivatives based on structure RBN-2397. Among these derivatives, (S)-XY-05 was identified as most promising inhibitor (IC50: 4.5 nM). Additionally, showed enhanced...
Inspired by the structure and function of mussel adhesive protein, a facile strategy involving oxidative polymerization dopamine was proposed for surface modification nanostructured lipid carriers (NLCs) to promote drug delivery in skin. The formation polydopamine (PDA) layer rounding NLCs confirmed X-ray photoelectron spectroscopy Fourier transform infrared studies. Using terbinafine (TBF) as model drug, vitro permeation study revealed that PDA coating significantly enhanced TBF from deep...
Rhabdomyosarcoma (RMS), a mesenchymal tumor occurring in the soft tissue of children, is associated with defect differentiation. This study unveils novel anti-tumor mechanism dimethylaminomicheliolide (DMAMCL), which water-soluble derivative Micheliolide. First, we demonstrate that DMAMCL inhibits RMS cell growth without obvious death, leading to morphological alterations, enhanced expression muscle differentiation markers, and shift from malignant more benign metabolic phenotype. Second,...
A Panax ginseng extract (PGE) with a quantified amount of ginsenosides was utilized to investigate its potential inhibit proliferation, influence lipid acquisition and adiponectin expression in 3T3-L1 cells. Seven fingerprint were using high performance liquid chromatography their respective molecular weights further confirmed via LC-ESI-MS analysis from four different extraction methods. Extraction methanol under reflux produced significantly higher amounts ginsenosides. The consisted Rg1...