A5100373280- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- MicroRNA in disease regulation
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Energy, Environment, Economic Growth
- Immunotherapy and Immune Responses
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- PARP inhibition in cancer therapy
- Monetary Policy and Economic Impact
- Cancer Immunotherapy and Biomarkers
- Dementia and Cognitive Impairment Research
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Magnesium Alloys: Properties and Applications
- Biosimilars and Bioanalytical Methods
- Aluminum Alloys Composites Properties
- Market Dynamics and Volatility
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
Southern Medical University
2022-2025
Cell Technology (China)
2025
Nanfang Hospital
2022-2025
Virginia Commonwealth University
2025
Sichuan Agricultural University
2025
Taiyuan University of Technology
2024
Kaifeng University
2024
Inner Mongolia Comprehensive Disease Prevention and Control Center
2024
Wenzhou Medical University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Abstract Objectives Older people are more likely to have digital exclusion, which is associated with poor health. This study investigated the relationship between exclusion and cognitive impairment in older adults from 23 countries across five longitudinal surveys. Design measurements Digital defined as self-reported non-use of Internet. We assessed on three dimensions: orientation, memory, executive function. used generalized estimation equations fitting binary logistic regression...
Abstract The complement system and neutrophils constitute the two main pillars of host innate immune defense against infection by bacterial pathogens. Here, we identify T-Mac, a novel virulence factor periodontal pathogen Treponema denticola that allows bacteria to evade both systems. We show T-Mac is expressed as pre-protein cleaved into functional units. N-terminal fragment has immunoglobulin-like domains binds with high affinity major neutrophil chemokine receptors FPR1 CXCR1, blocking N...
Parkin is an E3 ubiquitin ligase encoded by the gene (also called PARK2, located at 6q25.2-q27) and involved in pathogenesis of Parkinson's disease development cancer. Recently, has been demonstrated to interact with microtubule cytoskeleton. However, biological implication Parkin-microtubule axis poorly explored. In this study, we report for first time that modulates sensitivity chemotherapeutic agent paclitaxel breast cancer, via a microtubule-dependent mechanism. Our data reveal binds...
The purpose of this study was to investigate the regulatory effects breast cancer fibroblasts (BCFs) vs. normal mammary (NMFs) on mammosphere formation and stem cell-related gene expression in cells. Breast cells (MCF-7) were cultured suspension generate primary secondary mammospheres. proportion CD44+/CD24low/- assessed by flow cytometry (FCM), Wnt1, Notch1, β-catenin, CXCR4, SOX2 ALDH3A1 detected quantitative real-time PCR. from either tissue or purified specimens co-cultured with efficacy...
PARP7 plays a crucial role in cancer immunity. The inhibition of has shown potential boosting the immune response against cancer, making it an attractive target for immunotherapy. Herein, we employed rigid constraint strategy (reduction molecular flexibility) to design and synthesize series novel indazole-7-carboxamide derivatives based on structure RBN-2397. Among these derivatives, (S)-XY-05 was identified as most promising inhibitor (IC50: 4.5 nM). Additionally, showed enhanced...
Colorectal cancer (CRC) is one of the most malignant cancers with high morbidity and mortality. MicroRNAs (miRNAs) are small noncoding RNAs that affect biological processes by binding to mRNAs regulating their expression, epigenetic alterations including miRNA dysregulation significantly involved in CRC development. Determining effect miRNA-mRNA network on could be helpful for developing novel therapeutic targets prognostic biomarkers, even improving survival. In this study, microarray...
Angiotensin II (Ang II) mediated signaling plays a key role in the development of chronic kidney damage that contributes to renal fibrosis. However, gene expression changes regulated by Ang early stage acute injury remain unclear.C57BL/6 wild-type (WT) mice were injected with (1500 ng/kg/min) for 1, 3 and 7 days. A time series analysis microarrays was performed evaluate II-induced differentially kidneys. The data further dissected ANOVA analysis, profiles, network construction quantitative...
Abstract Background Taking advantage of nanobodies (Nbs) in immunotherapy, we investigated the cytotoxicity Nb-based chimeric antigen receptor T cells (Nb CAR-T) against lymphoma cells. Methods CD19 Nb CAR-T, CD20 and Bispecific CAR-T were generated by panning anti-human CD19- CD20-specific nanobody sequences from a natural Nb-expressing phage display library, integrating genes with lentiviral cassette that included other CAR elements, finally transducing expanded under an optimization...
Abstract Blocking of programmed death protein 1 (PD-1) or its ligand PD-L1 with corresponding antibody to enhance T-cell response and mediate antitumor activity has been successfully applied in clinical practice. Several immune checkpoint inhibitors including monoclonal antibodies (mAbs) targeting PD-1 have approved by the Food Drug Administration (FDA) cancer immunotherapy. However, application traditional limited due their drawbacks large molecular weight (MW) low tissue penetration. As...
Background: Quantification of bile acids using LC–MS has previously been very challenging on triple quadrupole MS systems due to the absence a primary fragment ion for unconjugated acids. Results: A LC–high-resolution/accurate mass method analysis six (cholic acid, chenodeoxycholic taurocholic deoxycholic lithocholic acid and ursodeoxycholic acid) was developed successfully validated. The includes single extraction injection with all analytes separated target-selected monitoring (SIM) mode...
Urotensin II (UII), a somatostatin-like cyclic peptide, is involved in tumor progression due to its mitogenic effect. Our previous study demonstrated that UII and receptor UT were up-regulated human hepatocellular carcinoma (HCC), exogenous promoted proliferation of hepatoma cell line BEL-7402. Hepatic progenitor (HPCs) are considered be one the origins liver cancer cells, but their relationship with remains unclear. In this work, we aimed investigate effect on ROS generation HPCs mechanisms...
Tuberculosis is a worldwide contagion caused by Mycobacterium tuberculosis (MTB). MTB characterized intracellular parasitism and semi-dormant inside host cells. The persistent inflammation can form granuloma in lesion regions intensify the latency of bacteria. In recent years, several studies have proven that long non-coding RNAs (lncRNAs) play critical roles modulating autophagy. our study, Gene Expression Omnibus (GEO) databases were searched for lncRNAs are associated with tuberculosis....
e14541 Background: Circulating tumor cell (CTCs) has the potential utility for screening, prognostic and predictive assessment, offers personalized management. This trial aimed to evaluate impact of programmed death ligand 1 (PD-L1) positive CTCs in patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Twenty-three heavily treated advanced PDAC were randomized receive camrelizumab combined apatinib or capecitabine, placebo plus capecitabine until disease progression unacceptable...
Cardiac hypertrophy without appropriate treatment eventually progresses to heart failure. Our recent data demonstrated that the immunoproteasome subunit β5i promotes cardiac hypertrophy. However, whether is a promising therapeutic target for treating hypertrophic remodeling remains unknown. Here we investigated effects of PR-957, β5i-specific inhibitor, on angiotensin II (Ang II)–induced in murine heart. The infusion Ang increased chymotrypsin-like activity and catalytic expression heart,...
The Shanghai crude oil futures market, as the largest market in Asia-Pacific region, is an important complement to global market. We use autoregressive distributed lag model (ARDL) examine long-term and short-term cointegration relations between China's spot (Daqing), international (WTI Brent) benchmarks. Based on price data of contract covering a long period, we find that, run, greatly affected by markets. In short both markets have significant influence prices. Moreover, our dynamic...
Trophoblast cell surface antigen 2 (TROP2) has emerged as a promising target of antibody-drug conjugates (ADCs) for triple-negative breast cancer (TNBC), well other cancers (BCs). This study aims to investigate the biomarker value TROP2 patient-tailoring and prognostic BC patients, including TNBC.The levels expression in 404 Chinese tissues on tissue microarrays (TMAs) were quantified by immunohistochemistry their correlations clinicopathological factors overall survival rate analyzed. Also,...