A5074259230- Intracranial Aneurysms: Treatment and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Ferroptosis and cancer prognosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer-related molecular mechanisms research
- Aldose Reductase and Taurine
- Alzheimer's disease research and treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological Complications and Syndromes
- Neurological Disease Mechanisms and Treatments
- Protein Degradation and Inhibitors
- Andrographolide Research and Applications
- Natural product bioactivities and synthesis
- Moyamoya disease diagnosis and treatment
- Autophagy in Disease and Therapy
- Ginger and Zingiberaceae research
- Neonatal and fetal brain pathology
- Vascular Malformations Diagnosis and Treatment
- Inflammation biomarkers and pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
- Phytochemistry and Biological Activities
Renmin Hospital of Wuhan University
2022-2025
Wuhan University
2022-2025
Neuroinflammation and neuronal apoptosis are closely associated with a poor prognosis in patients subarachnoid hemorrhage (SAH). We investigated the role of C-C motif chemokine receptor 2 (CCR2) SAH.Pre-processed RNA-seq transcriptome datasets GSE167110 GSE79416 from Gene Expression Omnibus (GEO) database were screened for genes differentially expressed between mice SAH control mice, using bioinformatics analysis. The endovascular perforation model was performed to establish SAH. RS504393 (a...
C-X-C chemokine receptor type 4 (CXCR4) is critical for homeostasis of the adaptive and innate immune system in some CNS diseases. Bruton's tyrosine kinase (BTK) an essential that regulates inflammation cells through multiple signaling pathways. This study aims to explore effect CXCR4 BTK on neuroinflammation pathogenesis early brain injury (EBI) after subarachnoid hemorrhage (SAH). Our results showed expression p-BTK increased significantly at 24 h SAH vivo vitro. Ibrutinib improved...
Ferroptosis, characterized by lipid peroxidation and intracellular iron accumulation, has been reported to be involving in the pathophysiological of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Although taurine reportedly yields neuroprotective effects multiple central neurological diseases can attenuated neuron damage stroke, its role EBI SAH remains unclear. The present study indicated that levels cerebrospinal fluid were significantly reduced patients, which suggested...
The most frequently identified central nervous system tumor in adults is glioblastoma multiforme (GBM). GBM prognosis remains poor despite multimodal treatment, i.e., surgery and radiation therapy with concurrent temozolomide-based chemotherapy. Silvestrol, an eIF4A inhibitor, has been demonstrated to be able kill cells previous studies. In this study, it was found that silvestrol considerably attenuated the proliferative potential of U251 U87 glioma reduced expression cyclin D1. addition,...
This study aimed to identify and evaluate the intracranial transplantation of dental pulp stem cells (DPSCs) as a possible ischemic stroke therapy that mitigates neuronal death/apoptosis.DPSCs were isolated from impacted third molars healthy volunteers then intracranially injected at 24 h post-ischemic Sprague Dawley rats had been subjected 2 middle cerebral artery occlusion. Neurological functional deficits assessed using modified neurological severity score (mNSS), edema was quantified...
Human dental pulp stem cells (hDPSCs) promote recovery after ischemic stroke; however, the therapeutic efficacy is limited by poor survival of transplanted cells. For in vitro experiments present study, we used oxygen-glucose deprivation/reoxygenation hDPSCs to mimic cell damage induced ischemia/reperfusion. We found that miRNA-34a-5p (miR-34a) was elevated under conditions hDPSCs. Inhibition miR-34a facilitated proliferation and antioxidant capacity reduced apoptosis Moreover,...
This study aimed to determine the ruptured rate and hemodynamic difference between wide-neck aneurysms (WNAs) narrow-neck (NNAs), as well parameters of risk factors for aneurysm rupture. A total 121 cases intracranial (IAs) were studied retrospectively January 2019 April 2021 at Renmin Hospital Wuhan University. Intracranial classified into four types: (RWNAs), unruptured (UWNAs), (RNNAs), (UNNAs). The Chi-square test was used compare differences in rupture ratios. clinical characteristics...
Background Predicting rupture risk is important for aneurysm management. This research aimed to develop and validate a nomogram model forecast the of posterior communicating artery (PcomA) aneurysms. Methods Clinical, morphological, hemodynamic parameters 107 unruptured PcomA aneurysms 225 ruptured were retrospectively analyzed. The least absolute shrinkage selection operator (LASSO) analysis was applied identify optimal factors, web-based dynamic developed accordingly. internally validated...
Moyamoya disease (MMD) is a teratogenic and lethal disease. However, existing studies do not sufficiently indicate the impact factors. Therefore, we investigated different factors on cerebral hemodynamics after revascularization in patients with MMD.We retrospectively collected clinical data of 233 adult MMD who underwent surgery Department Neurosurgery, Renmin Hospital Wuhan University, from January 2015 to June 2021 for this retrospective cohort study. We analyzed effects hemodynamic...
Abstract Background Hyperglycemia is a risk factor for poor prognosis after acute ischemic stroke and promote the occurrence of hemorrhagic transformation (HT). The activation P2RX7 play an important role in endotheliocyte damage BBB disruption. Ferroptosis novel pattern programmed cell death caused by accumulation intracellular iron lipid peroxidation, resulting ROS production death. This study to explore mechanism could reduce HT pathogenesis through regulating ferroptosis. Methods Male SD...
Ischemic stroke is a leading cause of mortality and permanent disability worldwide. Microglia, as the brain-resident immune cells, play biphasic role in ischemic depending on its polarization toward M1 or M2 phenotype. Betulinic acid (BA) natural bioactive molecule with potential to active CB2 receptor microglia promote polarization. Herein, we set explore regulation self-assembled BA nanoparticles (BA NPs) mediated microglial after brain ischemia. The vitro studies showed that could...
Abstract Ischemic stroke is a leading cause of mortality and permanent disability worldwide. Microglia, as the brain-resident immune cells, play biphasic role in ischemic depending on its polarization toward M1 or M2 phenotype. Betulinic acid (BA) natural bioactive molecule with potential to active CB2 receptor microglia promote polarization. Herein, we set explore regulation self-assembled BA nanoparticles (BA NPs) mediated microglial after brain ischemia. The vitro studies showed that...