A5038862760- Single-cell and spatial transcriptomics
- Immune cells in cancer
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Mechanisms of cancer metastasis
- Glycosylation and Glycoproteins Research
- Neurological Complications and Syndromes
- Extracellular vesicles in disease
- Drug Transport and Resistance Mechanisms
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Intracranial Aneurysms: Treatment and Complications
- Cancer Mechanisms and Therapy
- Barrier Structure and Function Studies
- Moyamoya disease diagnosis and treatment
- Angiogenesis and VEGF in Cancer
Wuhan University
2022-2025
Renmin Hospital of Wuhan University
2022-2025
Ludwig-Maximilians-Universität München
2020-2021
LMU Klinikum
2020-2021
Molecular imaging is essential for diagnosis and treatment planning glioblastoma patients. Positron emission tomography (PET) with tracers the detection of solute carrier family 7 member 5 (SLC7A5; also known as amino acid transporter light chain L system, LAT1) mitochondrial translocator protein (TSPO) successfully used to provide additional information on tumor volume prognosis. The current approaches TSPO-PET visualization tracer ([18F] Fluoroethyltyrosine, FET) uptake by LAT1 (FET-PET)...
The Fc Fragment of IgG Binding Protein (FCGBP) has been proven to participate in intestinal tumor immunity. However, the biological role FCGBP remained unclear glioma. differential expression was explored by Oncomine and GEPIA databases. effect on prognosis analyzed via Kaplan–Meier plotter GEPIA. Tumor Immune Estimation Resource (TIMER) tool used determine correlations with immune infiltration. Firstly, highly expressed glioma correlated a worse prognosis. Gene Ontology (GO) KEGG pathway...
Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases disease progression. We investigated the microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well histopathology characterized a previously unacknowledged population tumor-associated myeloid-like expression profile (TAMEP) that transiently appeared during...
Objective: Angiogenesis is a pathological feature of glioblastoma. Nicotinamide adenine dinucleotide phosphate oxidase 4 ( NOX4 ) vital source reactive oxygen species (ROS) related to angiogenesis. However, signaling pathways correlated with the isoform are unknown. The aim this study was elucidate detailed mechanism role in angiogenesis Methods: Public datasets were searched for studies on immunohistochemistry and western blotting evaluate expression glioma. location detected by...
Moyamoya disease (MMD) is a teratogenic and lethal disease. However, existing studies do not sufficiently indicate the impact factors. Therefore, we investigated different factors on cerebral hemodynamics after revascularization in patients with MMD.We retrospectively collected clinical data of 233 adult MMD who underwent surgery Department Neurosurgery, Renmin Hospital Wuhan University, from January 2015 to June 2021 for this retrospective cohort study. We analyzed effects hemodynamic...
Pericytes are essential for maintaining the stability of CNS blood-vessels and blood-brain-barrier. They closely associated with endothelia can be identified by a set markers. New pericytes required during neo-angiogenesis but how generated in adult brain is largely unknown. We investigated neoplastic vascularization transgenic lineage-tracing model. observed that vast majority mature originates from newly precursor cell-type. These precursors characterized as pericyte marker-negative cells...
e14044 Background: Aggressive brain tumors like glioblastoma depend on support by their local environment. While the role of tumor-associated myeloid cells progression is well-documented, we have only partial knowledge pathological impact -parenchymal progenitor cells. Methods: We investigated microenvironment with transgenic lineage-tracing models ( nestin-creER2, R26-tdTomato and sox2-creER2,R26-tdTomato), intravital imaging, single-cell transcriptomics, immunofluorescence flow-cytometry...
Abstract Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases disease progression. We investigated the microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well histopathology characterized a previously unacknowledged population tumor-associated myeloid-like expression profile (TAMEP) that transiently appeared...