A5101533046- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Gut microbiota and health
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Circular RNAs in diseases
- Advanced Photocatalysis Techniques
- Extracellular vesicles in disease
- Cell death mechanisms and regulation
- RNA Research and Splicing
- Mechanisms of cancer metastasis
- RNA modifications and cancer
- Data Stream Mining Techniques
- Kruppel-like factors research
- Chromatin Remodeling and Cancer
- Gas Sensing Nanomaterials and Sensors
- Pharmaceutical and Antibiotic Environmental Impacts
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Nicotinic Acetylcholine Receptors Study
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- Microbial Community Ecology and Physiology
Yunnan University
2025
Xuzhou Medical College
2017-2025
Qilu Hospital of Shandong University
2023-2025
Peking Union Medical College Hospital
2024
RWTH Aachen University
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
University College London
2024
Chongqing Normal University
2024
Microbiology Institute of Shaanxi
2023-2024
Institute of Microbiology
2023-2024
Abstract Background Mesenchymal stem cells including adipose-derived (ASCs) have a considerable potential in the field of translational medicine. Unfortunately, multiple factors (e.g., older age, co-existing diabetes, and obesity) may impair cellular function, which hinders overall effectiveness autologous cell therapy. Noncoding RNAs—including microRNAs (miRNAs), long ncRNAs (lncRNAs), circular RNAs (circRNAs)—have been shown to play important roles biology. However, diabetes-related...
Huntington's disease (HD) is a neurodegenerative disease. MicroRNAs (miRNAs) are small non-coding RNAs that mediate post-transcriptional regulation of target genes. Although miRNAs extensively edited in human brains, the editome brains HD patients largely unknown. By analyzing RNA sequencing profiles brain tissues 28 and 83 normal controls, 1182 miRNA editing sites with significant levels were identified. In addition to 27 A-to-I sites, we identified 3 conserved C-to-U patients. 30 SNPs also...
Staphylococcus aureus infection is a severe public health concern with the growing number of multidrug-resistant strains. S. can circumvent defense mechanisms host immunity aid multiple virulence factors. An efficacious multicomponent vaccine targeting diverse immune evasion strategies developed by thus crucial for its control. In this study, we exploited SpyCatcher-SpyTag system to engineer bacterial outer membrane vesicles (OMVs) development multitargeting click vaccine. We decorated OMVs...
Abstract Noise‐induced hearing loss (NIHL) results from prolonged exposure to intense noise, causing damage sensory outer hair cells (OHCs) and spiral ganglion neurons (SGNs). The blood labyrinth barrier (BLB) hinders systemic drug delivery the inner ear. This study applied a retro‐auricular round window membrane (RWM) method bypass BLB, enabling transport of macromolecular proteins into Pigment epithelium‐derived factor (PEDF), which has anti‐inflammatory neuroprotective properties, is...
N-Acetylcysteine (NAC) has been proposed to be used treat Coronavirus Disease 2019 (COVID-19). By reviewing the existing pathological studies of COVID-19, it was found that abundant mucus secretion, formation a hyaline membrane (supportive acute respiratory distress syndrome), and interstitial fibrous exudation may important characteristics COVID-19 targets drug therapy. In addition, multiple extrapulmonary organ injuries in COVID- 19 associated with cytokine storm. NAC is an antioxidant...
Background Circular RNAs (circRNAs) are closely associated with the occurrences and progress of gastric cancer (GC). We aimed to delve into function pathological mechanism RNA-0002570 (circ-0002570) in GC progression. Methods CircRNAs differentially expressed were screened using bioinformatics technology. The expression circ-0002570 was detected specimens cells via qRT-PCR, prognostic values determined. functional roles on proliferation, migration, invasion explored vitro vivo . Interaction...
A recent global scale study found that mining-impacted environments have multi-antibiotic resistance gene (ARG)-dominated resistomes with an abundance similar to urban sewage but much higher than freshwater sediment. These findings raised concern mining may increase the risk of ARG environmental proliferation. The current assessed how typical multimetal(loid)-enriched coal-source acid mine drainage (AMD) contamination affects soil by comparing background soils unaffected AMD. Both...
Adipose-derived stem cells (ADSCs) can differentiate into Schwann (SCs) at the site of nerve injury, where cell-derived exosomes (SC-Exos) are suspected to exert an induction effect. Our study aimed induce differentiation ADSCs in vitro using SC-Exos and investigate mechanisms involved through miRNA sequencing. Subcutaneous fat was used extract ADSCs. Exosomes were extracted from cell lines (RSC96) ultracentrifugation able be taken up by human After 8 days SC-Exos, phenotypic characteristics...
Abstract In spite of the promising initial treatment responses presented by photodynamic therapy (PDT), 5‐year recurrence rates remain high level. Therefore, improvement in efficacy PDT is needed. There are reports showing that connexin(Cx) 26‐composed gap junctional intercellular communication (GJIC) enhances propagation “death signal”, thereby increasing chemotherapeutic cytotoxicity. However, it unclear whether Cx26‐formed GJIC has an effect on phototoxicity. The results present study...
Extracellular vesicles (EVs) are newly appreciated communicators involved in intercellular crosstalk, and have emerged as a promising biomimetic tool for bone tissue regeneration, overcoming many of the limitations associated with cell-based therapies. However, significance osteoblast-derived extracellular on osteogenesis has not been fully established. In this present study, we aim to investigate therapeutic potential secreted from consecutive 14 days dexamethasone-stimulated osteoblasts...
This study sought to identify the downstream target genes of enolase 1 (ENO1), clarify role ENO1 in gastric cancer (GC), and provide novel insights into regulatory mechanisms occurrence development GC.We performed RNA-immunoprecipitation sequencing MKN-45 cells types abundance pre-messenger RNA (mRNA)/mRNA bound by ENO1, binding sites motifs, relationship between its regulation transcription level, alternative splicing level combining with RNA-sequencing (RNA-seq) data further found that...
The Medical Segment Anything Model (MedSAM) has shown remarkable performance in medical image segmentation, drawing significant attention the field. However, its sensitivity to varying prompt types and locations poses challenges. This paper addresses these challenges by focusing on development of reliable prompts that enhance MedSAM's accuracy. We introduce MedSAM-U, an uncertainty-guided framework designed automatically refine multi-prompt inputs for more precise segmentation. Specifically,...
Two new prenylated xanthones, mangoxanthones A-B (1-2), together with four known compounds 3-6, were isolated from the ethanol extract of pericarp Garcinia mangostana. The structures these have been elucidated based on spectroscopic analysis. analysis results chiral HPLC revealed 1 and 2 scalemic mixtures respectively. All biologically evaluated for their α-glucosidase α-amylase inhibitory effects using in-vitro assays. Compound showed moderate activities against IC50 29.06 ± 1.86 22.74 2.07...
Abstract Background The cultivated gut microbial resource plays essential role in microbiome studies such as function and their interactions with host. Though several major had been performed to understand the cultured human microbiota, up 70% of Unified Human Gastrointestinal Genome species remain uncultivated taxonomy is not clear. Large-scale isolation identification access pubic are imperative for understanding functions. Results Here, we report construction an Gut Microbial Biobank...
Colorectal carcinoma (CRC) treatment remains severe. Survivin is aberrantly overexpressed in CRC tissues and might be a potential target for treatment. TDB-6 new taspine derivative. The purpose of this study to investigate the inhibitory effect on its underlying mechanism.The MTT assay xenograft model were utilized LoVo cells vitro vivo. Hoechst staining Annexin-V FITC/PI analysis conducted cell apoptosis. Mitochondrial membrane (Δψm) was demonstrated whether could induce...