A5100384576- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Soil erosion and sediment transport
- ATP Synthase and ATPases Research
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Hematopoietic Stem Cell Transplantation
- RNA Interference and Gene Delivery
- Molecular Sensors and Ion Detection
- Karst Systems and Hydrogeology
- Radiopharmaceutical Chemistry and Applications
- Food Quality and Safety Studies
- Biochemical and biochemical processes
- RNA modifications and cancer
- Hydrology and Watershed Management Studies
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Tannin, Tannase and Anticancer Activities
- Histone Deacetylase Inhibitors Research
- Hydrology and Sediment Transport Processes
- Medical Imaging and Pathology Studies
- Memory and Neural Mechanisms
- Listeria monocytogenes in Food Safety
- Ferroptosis and cancer prognosis
Renji Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Sichuan University
2009-2025
State Key Laboratory of Oral Diseases
2025
Guizhou University
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Zhejiang University
2022
State Key Laboratory of Clean Energy Utilization
2022
Soochow University
2015-2022
Second Affiliated Hospital of Soochow University
2019-2022
Taxane and vinblastine represent two classes of microtubules-targeted agents for cancer chemotherapy. Although taxol are widely used treatment, resistance to these is frequently encountered in the clinic. An ongoing question has been what mechanisms involved tumour cells or how clinical effectiveness can be improved. There increasing evidence that microtubules interact with endoplasmic reticulum (ER). Here, we have shown induce multiple arms ER stress response, including up-regulation...
Smoking is the leading cause of COPD. Exploring molecular markers and understanding pathogenic mechanisms smoking-related COPD are helpful for early clinical diagnosis treatment disease. This study aims to identify specific circulating microRNAs (miRNAs) from blood patients with a long history smoking.Blood samples four different groups were collected, miRNA microarray was performed. Differential expression miRNAs verified by quantitative polymerase chain reaction. In vitro, THP-1 cells...
The diagnosis and surveillance of clear cell renal carcinoma (ccRCC) remains a clinical challenge. high specific expression the cluster differentiation 70 (CD70) in ccRCC makes it potential diagnostic therapeutic target.
CD70 is an emerging biomarker for both solid tumors and hematologic malignancies, highlighting the urgent need a molecular imaging tracer capable of visualizing with favorable pharmacokinetics. Methods: ABDB6 was prepared by fusing albumin-binding domain ABD035 CD70-targeting single-domain antibody RCCB6, which we previously reported. The resulting then conjugated to bifunctional chelator p-SCN-NOTA labeled 64Cu produce [64Cu]Cu-NOTA-ABDB6. Flow cytometry used screen 6 lymphoma cell lines...
Despite significant progress in characterizing the omics landscape of head and neck squamous cell carcinoma (HNSCC), development precision therapies remains limited. One key factor contributing to this challenge is marked molecular heterogeneity HNSCC. Further investigation profiles within HNSCC may facilitate improvement more effective treatments. Here, we focus on dysregulation PDZ LIM domain protein 3 (PDLIM3) The expression levels PDLIM3 were analyzed using public datasets assess its...
The development of metastases involves the dissociation cells from primary tumor, penetrating basement membrane, invasion and exiting vasculature to seed, finally colonizing in distant tissues. formation brain metastasis (BM) lung adenocarcinoma remains poorly understood. We examined differential microRNA (miRNA) expression profiles 5 3 metastatic samples by Agilent miRNA Microarrays. Five upregulated miRNAs (miRs-9*, -1471, 718, 3656, 720) downregulated (miRs-214, -145 -23a) were detected....
Background: Dysregulation of lipid metabolism plays important roles in the tumorigenesis and progression gastric cancer (GC). The present study aimed to establish a prognostic model based on metabolism–related genes GC patients. Materials Methods: Two datasets from Gene Expression Atlas, GSE62254 ( n = 300) GSE26942 217), were used as training validation cohorts risk predictive scoring model. efficacy this was assessed by ROC analysis. association scores with patient characteristics immune...
The function of human transmembrane protein 176A (TMEM176A) in cancer remains unclear. To understand the and mechanism TMEM176A esophageal development, 13 cell lines 267 cases primary squamous (ESCC) samples were analyzed by methylation specific PCR (MSP), flow cytometry, immunohistochemistry transfection assays. was highly expressed BIC1 cells loss expression found TE1, TE3, TE13, KYSE140, KYSE180, KYSE410, KYSE450, KYSE520, Segl, KYSE150, YES2 COLO680N cells. Complete detected cells, while...
Researches show that androgens have important effects on migration of endothelial cells and protection in coronary heart disease. Endothelial progenitor (EPCs) as a cell type can differentiate into cells, critical role angiogenesis protection. The relationship between androgen the functions EPCs has animated much interest controversy. In this study, we investigated angiogenic migratory after treatment by dihydrotestosterone (DHT) molecular mechanisms well. We found DHT enhanced incorporation...
Intracranial infection of Listeria monocytogenes (LM) can lead to various manifestations, including meningitis, meningoencephalitis, brainstem encephalitis, and brain abscess, which often have a poor prognosis. Metagenomic next-generation sequencing (mNGS) is promising new tool for the diagnosis intracranial LM. We describe typical clinical manifestations LM highlight its rarity severity help physicians better understand disease characteristics.Six cases severe were diagnosed by mNGS....
Soil carbon in karst critical zones is an essential part of the global pool, and migration dissolved a vital component cycle such regions. The unique "dual hydrological structure" makes path process soil driven by rainfall unclear slopes, which ultimately hinders accurate evaluation sink effect Therefore, based on field monitoring natural rainfall, this study evaluated characteristics spatial bare slopes its response to (rainfall duration amount). results showed that concentration...
Immuno-PET/CT imaging, a branch of molecular can noninvasively and specifically visualize biomarker expression across the body. Trophoblast cell surface antigen 2 (Trop2) is pan-cancer plays crucial role in tumorigenesis through multiple signaling pathways. The study aims to develop translate novel Trop2 single-domain antibody (sdAb) tracers for clinical use. <b>Methods:</b> Two sdAbs (i.e., His-tagged T4 His-tag−free RT4) are recombinantly expressed Chinese hamster ovary cells. purities...
Multiple myeloma (MM) is a malignant disease associated with clonal plasma cell proliferative disorder, characterized by extensive infiltration of cells in the bone marrow, for which proportion patients suffer poor outcome and exhibit no obvious symptoms early stages. Amyloidosis rare condition caused MM. Immunoglobulin light chain amyloidosis (AL) secretion specific toxic proteins from proliferating B or cells. These accumulate human tissues cause organ dysfunction failure. Oral...