A5102010267- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Asthma and respiratory diseases
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Heart Disease Studies
- IL-33, ST2, and ILC Pathways
- Coronary Artery Anomalies
- Parathyroid Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Respiratory and Cough-Related Research
- Tissue Engineering and Regenerative Medicine
- Diagnosis and Treatment of Venous Diseases
- Pulmonary Hypertension Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
Sichuan University
2015-2025
State Key Laboratory of Oral Diseases
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
West China Hospital of Sichuan University
2015-2024
Weatherford College
2021
Lanzhou University
2014
Jiangxi University of Traditional Chinese Medicine
2012
Graduate School USA
1997-1998
Engineering three-dimensional (3D) vascularized constructs remains a challenge due to the inability form rich microvessel networks. In this study we engineered prevascularized 3D cell sheet construct for tissue regeneration using human bone marrow-derived mesenchymal stem cells (hMSCs) and umbilical vein endothelial as sources. hMSCs were cultured thick sheet, (HUVECs) then seeded on The single HUVEC/hMSC was folded by modified engineering technique. vitro results indicated that promoted...
Purpose To measure left ventricular (LV) myocardial strain with cine magnetic resonance (MR) imaging and a deformable registration algorithm (DRA) to assess the prognostic value of in patients light-chain (AL) amyloidosis. Materials Methods In this prospective study, 78 consecutive AL amyloidosis who underwent contrast material-enhanced cardiac MR were enrolled at West China Hospital. LV strains late gadolinium enhancement (LGE) evaluated. Association between all-cause mortality was analyzed...
Despite significant progress in characterizing the omics landscape of head and neck squamous cell carcinoma (HNSCC), development precision therapies remains limited. One key factor contributing to this challenge is marked molecular heterogeneity HNSCC. Further investigation profiles within HNSCC may facilitate improvement more effective treatments. Here, we focus on dysregulation PDZ LIM domain protein 3 (PDLIM3) The expression levels PDLIM3 were analyzed using public datasets assess its...
Background: Diffuse myocardial fibrosis is a common pathological process in many cardiovascular diseases. In order to determine disease, we must have standard normal imaging values. We investigated interstitial of the left ventricle (LV) healthy population Chinese adults and explored impact gender, age, other physiological factors using T1 mapping technique cardiac magnetic resonance (CMR). Materials Methods: recruited 69 adult subjects (35 males; age 18–76). LV function global strain were...
Abstract The size and function of the left atrium (LA) right (RA) are related closely with prognosis cardiovascular diseases. However, their normal reference values, as measured by cardiac magnetic resonance (CMR), not well established in Chinese populations. Healthy subjects (n = 135, 66 males, age 23–83 years) without risk factors were recruited. We imaged LA RA all using short axis long slices steady-state free precession (SSFP) sequences a 3.0T scanner. functional parameters measured....
The prognostic value of left atrial (LA) size and function in hypertrophic cardiomyopathy (HCM) is well recognized, but LA difficult to routinely analyze. Fast long-axis strain (LA-LAS) analysis a novel technique assess on cine cardiovascular magnetic resonance (CMR). We aimed the association between fast LA-LAS adverse clinical outcomes patients with HCM. 359 HCM 100 healthy controls underwent routine CMR imaging. was analyzed by automatically tracking length midpoint posterior wall...
Few studies have focused on right ventricular (RV) involvement in cardiac amyloidosis (CA). We investigated the prognostic value of RV assessment by cardiovascular magnetic resonance (CMR) CA. In 2011-2014, consecutive patients with suspected CA referred for CMR were retrospectively evaluated. Demographic and baseline clinical characteristics collected. Healthy volunteers matched sex age served as controls. All subjects underwent a contrast-enhanced examination. size, function, late...
Myocardial fibrosis is a common pathophysiological process that related to ventricular remodeling in congenital heart disease. However, the presence, characteristics, and clinical significance of myocardial Ebstein's anomaly have not been fully investigated. This study aimed evaluate using cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) T1 mapping techniques, explore adolescent adult patients with anomaly. Forty-four consecutive unrepaired (34.0 ± 16.2 years; 18...
Segmental myocardial strain using feature tracking (FT) cardiac MRI is not acceptable due to poor reproducibility.To assess the reproducibility of left ventricle (LV) segmental measured by deformation registration algorithm (DRA).Prospective clinical trial.Sixteen healthy volunteers and 28 hypertrophic cardiomyopathy (HCM) patients.Retrospective ECG gating imaging was performed at 3.0T with a steady-state free precession (SSFP) sequence.LV global strains were analyzed DRA, FT, speckle...
This study was designed to aid health care providers in better understanding the need for earlier recognition of allergic bronchopulmonary aspergillosis/allergic mycosis (ABPA/ABPM). Patients with a confirmed diagnosis ABPA/ABPM after evaluation Department Respiratory Medicine Zhongshan Hospital affiliated Fudan University between March 2003 and January 2013 were analyzed retrospectively. Clinical signs symptoms, previous diagnoses potential diagnostic errors, serologic tests chest computed...
Purpose To establish normal reference values of left ventricular (LV) and right (RV) dimension, volume, mass, ejection fraction in a Chinese population using cardiac magnetic resonance imaging (MRI). Materials Methods A total 120 (60 males; 60 females; 23–83 years) healthy Han subjects without cardiovascular disease or risk factors were recruited. They underwent comprehensive MRI examination at 3.0T. LV/RV morphology function evaluated by steady‐state free‐procession (SSFP) sequence....
The cine magnetic resonance imaging based technique feature tracking-cardiac (FT-CMR) is emerging as a novel, simple and robust method to evaluate myocardial strain. We investigated the distribution characteristics of left-ventricular strain using novel MRI deformation registration algorithm (DRA) in cohort healthy Chinese subjects. A total 130 subjects were enrolled. Three components orthogonal (radial, circumferential, longitudinal) left ventricle analyzed DRA on steady-state free...
Late gadolinium enhancement (LGE) pattern is a powerful imaging biomarker for prognosis of cardiac amyloidosis. It unknown if the query amyloid late (QALE) score in light-chain (AL) amyloidosis could provide increased prognostic value compared with LGE pattern.Methods and Results:Seventy-eight consecutive patients AL underwent contrast-enhanced cardiovascular magnetic resonance imaging. Patients involvement were grouped by analyzed using QALE score. Receiver operating characteristic curve...
IL-17A-producing group 3 innate lymphoid cells (ILC3s) have been found to participate in the development of various phenotypes asthma, however, little is known about how ILC3s mediate neutrophilic airway inflammation. Elevated IL-1β has reported asthma (NA) and receptor highly expressed on lung ILC3s. Therefore, we hypothesize that aggravates inflammation via provoking We sought determine pathological roles IL-1β-ILC3-IL-17A axis Lung ILC subsets were measured eosinophilic (ovalbumin...
Vomiting is a common clinical symptom in which the conditions associated with impaired homeostasis and qi flow ascend reversely within stomach, resulting expulsion of stomach's contents through mouth. The located middle warmer (also known as Zhong Jiao), primarily responsible for receiving digesting food liquid, its typically flows downward. Various unfavorable environment, food, mental health, or physiological stress can compromise thereby leading to loss gastric homeostasis, often triggers...
BACKGROUND:In regular examinations, it may be difficult to visually identify benign and malignant liver tumors based on plain computed tomography (CT) images. RCAD (radiomics-based computer-aided diagnosis) has proven helpful provide interpretability in clinical use. OBJECTIVE:This work a ims develop CT-based radiomics signature investigate its correlation with malignant/benign tumors. METHODS:We retrospectively analyzed 168 patients of hepatocellular carcinoma (malignant) 117 hepatic...