A5101578707- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Computational Drug Discovery Methods
- Cancer, Stress, Anesthesia, and Immune Response
- Respiratory viral infections research
- Traditional Chinese Medicine Studies
- Cancer Cells and Metastasis
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Obstructive Sleep Apnea Research
- Pulmonary Hypertension Research and Treatments
- Health and Medical Studies
- MicroRNA in disease regulation
- Esophageal Cancer Research and Treatment
- Proteoglycans and glycosaminoglycans research
- Cancer Immunotherapy and Biomarkers
- Cystic Fibrosis Research Advances
- Body Composition Measurement Techniques
- Autophagy in Disease and Therapy
Sichuan University
2015-2025
West China Hospital of Sichuan University
2004-2025
Beijing Friendship Hospital
2012-2023
Capital Medical University
2012-2023
Northwest Normal University
2018-2021
Hangzhou Xixi hospital
2018-2021
Affiliated Zhongshan Hospital of Dalian University
2012-2016
China-Japan Friendship Hospital
2015
Southern Medical University
2015
Nanfang Hospital
2015
Objective To evaluate the effect of ethyl pyruvate (EP) in improving survival and ameliorating distant organ damage to investigate role high-mobility group box (HMGB) 1 rats with established severe acute pancreatitis (SAP). Methods Severe was induced by retrograde infusion sodium taurodeoxycholate (5%, mL/kg) into biliopancreatic ducts male Wistar rats. The were infused intravenously EP 40 mg/kg, 4 0.4 mg/kg initiating 12 hours, administered beginning 2 hours before surgery (−2 hours) 12,...
Background: Airway structure changes, termed as airway remodeling, are common in asthma patients due to chronic inflammation, which can be assessed by high-resolution computed tomography (HRCT). Considering the controversial conclusions correlation of morphologic abnormalities with clinical feature and outcome, we aimed further specify evaluate structural Chinese asthmatics HRCT.
IL-17A-producing group 3 innate lymphoid cells (ILC3s) have been found to participate in the development of various phenotypes asthma, however, little is known about how ILC3s mediate neutrophilic airway inflammation. Elevated IL-1β has reported asthma (NA) and receptor highly expressed on lung ILC3s. Therefore, we hypothesize that aggravates inflammation via provoking We sought determine pathological roles IL-1β-ILC3-IL-17A axis Lung ILC subsets were measured eosinophilic (ovalbumin...
The persistent administration of β2‑adrenergic (β2AR) agonists has been demonstrated to increase the risk severe asthma, partly due induction tolerance bronchoprotection via undefined mechanisms. present study investigated potential effect long‑acting agonist, formoterol, on expression muscarinic M3 receptor (M3R) in rat airway smooth muscle cells (ASMCs). Primary ASMCs were isolated and characterized following immunostaining with anti‑α‑smooth actin antibodies. protein levels M3R...
Abstract Assessment of reproductive toxicity is one the important safety considerations in drug development. Thus, present research, naïve Bayes (NB)‐classifier method was applied to develop binary classification models. Six molecular descriptors for were selected by genetic algorithm. Then, 110 models developed using six and10 types fingerprints with 11 different maximum diameters. Among these established models, model based on and SciTegic extended‐connectivity 20 diameters (LCFC_20)...
Background Obstructive sleep apnea (OSA) is the most prevalent disturbance that affects approximately 936 million people worldwide and leads to extensively increased incidence of cardiovascular disease, metabolic syndrome, neurological disorders, traffic accidents. Severe OSA patients suffer a significantly higher risk complications worse comorbidity outcomes. Notwithstanding, with inadequate access contact diagnosis based on polysomnography (PSG), numerous severe have not been diagnosed,...
Abstract Roles of lung volumes in asthma remain controversial. We aimed to evaluate the efficacy differentiating severity levels. Consecutive outpatients with chronic persistent were enrolled, and body plethysmography (BP) helium dilution (HD) performed simultaneously extract RV%pred, TLC%pred, RV/TLC. Significant negative correlations found between FEV 1 %pred RV%pred (r = −0.557, P < 0.001), TLC%pred −0.387, RV/TLC −0.485, 0.001) measured by BP, as well difference these two techniques...